SNP Report

Basic Info

Name	rs1997644 dbSNP Ensembl
Location	chr22:38319217 - 38319217(1)
Variant Alleles	G/A
Ancestral Allele	G
Minor Allele	A
Minor Allele Frequence	0.371605
Functional Annotation	intron_variant; upstream_gene_variant.
Consequence to Transcript	intron_variant(ENST00000400206); upstream_gene_variant(ENST00000359867, ENST00000396832, ENST00000403904, ENST00000405675, ENST00000413574, ENST00000430335)
No. of Studies	3 (Positive: 2; Negative: 1; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	YES

SNP related studies (count: 3)

Reference	Allele Change	Statistical Values	Author Comments	Result Category
Soria, V.,2010		X²-tests: allele P-value = 0.396, Model Dominant,...... X²-tests: allele P-value = 0.396, Model Dominant, genotype P-value = 0.043, OR(95%CI)=1.53 (1.01-2.34) More...	Significant association was found in BD. Significant association was found in BD.	Positive
Mansour, H. A.,2009	A/G	Single SNP-based analyses: Trends test P-value = 0.024 in BP...... Single SNP-based analyses: Trends test P-value = 0.024 in BPI More...	Significant association was observed Significant association was observed	Positive
Matsunaga, S.,2012	A/G	Chi square test:MAF = 0.36,P-value = 0.051,OR = 0.89 Chi square test:MAF = 0.36,P-value = 0.051,OR = 0.89	No significant association was observed. No significant association was observed.	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
CSNK1E	casein kinase 1, epsilon	22q13.1	5(1/3/1)

SNPs in LD with rs1997644 (count: 0) View in gBrowse (chr22:38319217..38319217 )

Overlap with SZ from cross-disorder studies (count: 2)

Reference	Statistical Result	Description	Result Category
Matsunaga, S.,2012	Chi square test:MAF = 0.38,P-value = 0.89,OR = 0.99	No significant association was observed.	Negative
Mansour, H. A.,2009	Single SNP-based analyses:Trends test P-value = 0.363 in SZ	No significant association was observed	Negative

Overlap with MDD from cross-disorder studies (count: 2)

Reference	Statistical Result	Description	Result Category
Matsunaga, S.,2012	Chi square test:MAF = 0.37,P-value = 0.49,OR = 0.95	No significant association was observed.	Negative
Soria, V.,2010	X²-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model	No significant association was observed.	Negative