SNP Report

Basic Info

Name	rs2494732 dbSNP Ensembl
Location	chr14:104772855 - 104772855(1)
Variant Alleles	T/C
Ancestral Allele	C
Minor Allele	T
Minor Allele Frequence	0.425919
Functional Annotation	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant.
Consequence to Transcript	downstream_gene_variant(ENST00000553819, ENST00000554826, ENST00000555380, ENST00000555926, ENST00000556836, ENST00000557223); intron_variant(ENST00000349310, ENST00000402615, ENST00000407796, ENST00000544168, ENST00000553506, ENST00000554192, ENST00000554581, ENST00000554585, ENST00000554848, ENST00000555458, ENST00000555528, ENST00000557552, ENST00000610370, LRG_721t1, LRG_721t2); NMD_transcript_variant(ENST00000554585); non_coding_transcript_variant(ENST00000544168, ENST00000553506, ENST00000557552, ENST00000610370)
No. of Studies	2 (Positive: 1; Negative: 1; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	NO

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Karege, F.,2012	A/G		Association analysis: chi square=9.40; df=1; P-value = 0.002...... Association analysis: chi square=9.40; df=1; P-value = 0.002; P-value(adjusted)=0.01; OR(95%CI)=1.63(1.2-2.2) More...	Significant association was observed in BD. Significant association was observed in BD.	Positive
Karege, F.,2010	A/G		single-locus analysis: z=2.29; P-value = 0.022 single-locus analysis: z=2.29; P-value = 0.022	No significant association was observed in BD. No significant association was observed in BD.	Negative

SNP related genes (count: 2)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
SIVA1	SIVA1, apoptosis-inducing factor	14q32.33	1(0/1/0)
AKT1	v-akt murine thymoma viral oncogene homolog 1	14q32.33	3(3/0/0)

SNPs in LD with rs2494732 (count: 0) View in gBrowse (chr14:104772855..104772855 )

Overlap with SZ from cross-disorder studies (count: 2)

Reference	Statistical Result	Description	Result Category
Karege, F.,2012	Association analysis:chi square=4.90;df=1;P-value = 0.02;P-value(adjusted)>0.05;OR(95%CI)=1.57(1.0-2.3)	No significant association was observed in SZ.	Negative
Karege, F.,2010	single-locus analysis:z=1.73;P-value = 0.083	No significant association was observed.	Negative

Overlap with MDD from cross-disorder studies (count: 0)