Gene Report

Approved Symbol	DAOA
Symbol Alias	G72
Approved Name	D-amino acid oxidase activator
Name Alias	G72 transcript
Location	13q33.2
Position	chr13:105465867-105491034, 1
External Links	HGNC: 21191 Entrez Gene: 267012 Ensembl: ENSG00000182346 UCSC: uc001vqb.4
No. of Studies	21 (Positive: 13; Negative: 7; trend: 1)
Overlap with SZ?	YES
Overlap with MDD?	YES

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Maheshwari, M.,2009	SNP: rs1253464, rs12862108, rs1341402, rs1421292, rs1815686, rs1935057, rs1935058, rs1935062, rs2012887, rs2025522, rs2391191, rs3916964, rs3916965, rs3916966, rs3918342, rs41274240, rs67705083, rs701567, rs72661138, rs72661139, rs72661140, rs778293, rs778294, rs778326, rs778334, rs778336, rs7981258, rs7986339, rs7987770, rs9301029, rs9301030, rs9301034, rs947267, rs9519671, rs9519683, rs954581, rs9558551, rs9558581, rs978714	To summarize, we failed to detect significant disease association of common or rare variants in the DAOA gene region in relatively large sample sets, but found that rs1935058 best explained previously identified linkage signal in a specific family sample set. It remains possible that DAOA may contribute to bipolar susceptibility in some specific families.	Positive	Comment on Study
Muller, D. J.,2011	SNP: rs1341402, rs1935062, rs2391191, rs778294, rs947267 Haplotype: rs1341402 - rs2391191 - rs1935062(T-A-C), rs1341402 - rs2391191 - rs1935062 - rs947267(T-A-C-T), rs1341402 - rs2391191 - rs1935062 - rs947267 - rs778294(T-A-C-T-C), rs1935062 - rs947267(C-T), rs1935062 - rs947267 - rs778294(C-T-C), rs2391191 - rs1935062(A-C), rs2391191 - rs1935062 - rs947267(A-C-T), rs2391191 - rs1935062 - rs947267 - rs778294(A-C-T-C)	These findings suggest that the DAOA/G72 gene confers susceptibility to both BD and SZ, but that different polymorphisms may potentially differentiate between these two disorders.	Positive	Comment on Study
Schulze, T. G.,2005	SNP: rs1341402, rs1421292, rs2391191, rs3918342 Haplotype: rs1341402 - rs2391191 - rs3918342 - rs1421292(G-G-C-T), rs1341402 - rs2391191 - rs3918342 - rs1421292(G-G-T-A), rs3918342 - rs1421292(C-T), rs3918342 - rs1421292(T-A)	Our analysis revealed that the association between bipolar affective disorder and the DAOA/G30 locus is an association involving those with a history of persecutory delusions rather than bipolar affective disorder in general.	Positive	Comment on Study
Grigoroiu-Serbanescu, M.,2010	SNP: rs1341402, rs1421292, rs1935057, rs1935062, rs2391191, rs3916965, rs3916967, rs3916971, rs3918342, rs67705083, rs778293, rs778294, rs954581 Haplotype: rs3916967 - rs2391191() Other variant: DAOA_z6:1117	We report a potential association of different G72/G30-SNPs with non-psychotic mood episodes and with persecutory delusions in BPI Romanian patients.	Positive	Comment on Study
Tan, J., 2014	SNP: rs2391191, rs947267, rs3918342	DAOA genetic polymorphisms (M15, M18 and M23) were not found to confer a statistically significant increased risk of SCZ, BD or DD in the overall sample, or in Caucasians and Asians following subgroup analysis.	Negative	Comment on Study
Soronen, P.,2011	SNP: rs2391191, rs778336	No significant association of this gene was observed in BD.	Negative	Comment on Study
Fallin, M. D.,2005		14 SNP typed, Median D'=0.96, Median r<sup>2</sup> =0.15, 2 LD blocks, 1.33 block coverage, there exists SNP or haplotype nominal P-value < 0.01 in SZ and all SNP or haplotype P-value > 0.05 in BP.. This gene is suggestive to BP and SZ/SZA.	Trend	Comment on Study
Zhang, Z.,2009(a)	SNP: rs2391191, rs3916965, rs3918342, rs778293, rs778294 Haplotype: rs778293 - rs3918342(A-A), rs778293 - rs3918342(A-G), rs778293 - rs3918342(G-G), rs778294 - rs778293(G-A), rs778294 - rs778293(G-G)	In conclusion, our experimental data provide further evidence that variations in G72 confer susceptibility to BPD, as well as providing the first such evidence based on an Asian population.	Positive	Comment on Study
Zuliani, R.,2009	SNP: rs1421292, rs3918342	Genetic variation at single nucleotide polymorphisms in the G72 gene previously associated with bipolar disorder is related to reductions in temporal pole and amygdala gray matter structure in people with bipolar disorder.	Positive	Comment on Study
Bass, N. J.,2009	SNP: rs1341402, rs1421292, rs1935062, rs2111902, rs2391191, rs3741775, rs3916965, rs3916967, rs3918342, rs3918346, rs778293, rs778294, rs947267, rs954581	Our results provide some support for a role for DAOA in susceptibility to schizophrenia and bipolar disorder.	Positive	Comment on Study
Hukic, D. S.,2013	SNP: rs3916967, rs2391191, rs1935062 Haplotype: rs3916967 - rs2391191 - rs1935062(C-A-C), rs3916967 - rs2391191 - rs1935062(T-G-C), rs3916967 - rs2391191 - rs1935062(C-A-A), rs3916967 - rs2391191 - rs1935062(T-G-A)	Our finding are consistent with other studies showing genetic associations between the COMT and DAOA genes and impaired cognition both in psychiatric disorders and in the general population.	Positive	Comment on Study
Shi, J., 2008 (a)	SNP: rs1341402, rs1935058, rs1935062, rs2391191, rs778294	No single maker showed evidence of overall association with BP.	Negative	Comment on Study
Prata, D., 2008	SNP: rs2391191, rs3916966, rs3916972, rs746187 Haplotype: rs746187 - rs3916972(), rs746187 - rs3916972(1-1: G-G)	Analysis of each SNP individually showed no significant association.	Negative	Comment on Study
Hattori, E.,2003	SNP: rs1341402, rs1359387, rs1815686, rs1935058, rs1935062, rs1998654, rs2012887, rs2181953, rs2391191, rs778294, rs778334, rs947267, rs954581, rs978714 Haplotype: rs1935058 - rs1341402 - rs2391191 - rs1935062 - rs947267 - rs778294 - rs954581(C-C-G-A-C-A-T), rs1935058 - rs1341402 - rs2391191 - rs1935062 - rs947267 - rs778294 - rs954581(C-T-A-A-A-G-C), rs1935058 - rs1341402 - rs2391191 - rs1935062 - rs947267 - rs778294 - rs954581(C-T-A-C-A-G-T), rs1935058 - rs1341402 - rs2391191 - rs1935062 - rs947267 - rs778294 - rs954581(C-T-G-A-C-G-T), rs1935058 - rs1341402 - rs2391191 - rs1935062 - rs947267 - rs778294 - rs954581(T-T-G-A-A-G-C), rs1935058 - rs1341402 - rs2391191 - rs1935062 - rs947267 - rs778294 - rs954581(T-T-G-A-A-G-T), rs1935058 - rs1341402 - rs2391191 - rs1935062 - rs947267 - rs778294 - rs954581(T-T-G-A-C-A-T), rs1935058 - rs1341402 - rs2391191 - rs1935062 - rs947267 - rs778294 - rs954581(T-T-G-A-C-G-T)	These data suggest that a susceptibility variant for bipolar illness exists in the vicinity of the G72/G30 genes.	Positive	Comment on Study
Dalvie, S.,2010	SNP: rs701567	There were no significant difference in SNP allele frequencies between cases and controls.	Negative	Comment on Study
Gawlik, M.,2010	SNP: rs1935058, rs1935062, rs2391191, rs3916966, rs3918342, rs947267, rs9558575 Haplotype: rs1935058 - rs1935062 - rs2391191 - rs3916966()	Our data do not support a common genetic contribution of the DAOA/G30 gene complex to the pathogenesis of affective disorders.	Negative	Comment on Study
Gaysina, D.,2010	SNP: rs12584489, rs1421292, rs1935062, rs2391191, rs3916965, rs3918342, rs778292, rs947267, rs9558562 Haplotype: rs12584489 - rs2391191 - rs9558562(), rs1935062 - rs947267 - rs778292(), rs2391191 - rs9558562 - rs1935062(), rs3916965 - rs12584489 - rs2391191(), rs778292 - rs3918342 - rs1421292(), rs947267 - rs778292 - rs3918342(), rs9558562 - rs1935062 - rs947267(), rs1935062 - rs3741775(), rs3916965 - rs3741775()	In conclusion, our results in two independent Caucasian samples did not provide evidence for association of DAOA or DAO with BD, nor did we find convincing evidence of statistical epitasis.	Negative	Comment on Study
Williams, N. M., 2006	SNP: rs1341402, rs1421292, rs1935058, rs2391191, rs391695, rs778293, rs778294, rs954581 Other variant: DAOA_3'UTR_SNP12	Our results imply that variation at the DAOA/G30 locus influences susceptibility to episodes of mood disorder across the traditional bipolar and schizophrenia categories.	Positive	Comment on Study
Detera-Wadleigh, S. D., 2006	SNP: rs1341402, rs1421292, rs1935058, rs1935062, rs2391191, rs3916964, rs3916965, rs3916966, rs3916967, rs3916970, rs3916971, rs3918341, rs3918342, rs746187, rs778293, rs778294, rs947267, rs954581	In summary, this meta-analysis supports significant association of markers in the G72 region with both schizophrenia and bipolar affective disorder.	Positive	Comment on Study
Chen, Y. S.,2004	SNP: rs1935058, rs1935062, rs2391191, rs947267, rs954581 Haplotype: rs1935058 - rs2391191 - rs1935062 - rs947267 - rs954581(T-G-A-C-T), rs1935058 - rs2391191 - rs1935062 - rs947267 - rs954581(C-A-C-A-T), rs1935058 - rs2391191 - rs1935062 - rs947267 - rs954581(T-G-A-A-C), rs1935058 - rs2391191 - rs1935062 - rs947267 - rs954581(T-G-C-A-T), rs1935058 - rs2391191 - rs1935062 - rs947267 - rs954581(C-G-C-A-T), rs1935058 - rs2391191 - rs1935062 - rs947267 - rs954581(T-A-A-C-T), rs1935058 - rs2391191 - rs1935062 - rs947267 - rs954581(C-A-A-A-C), rs1935058 - rs2391191 - rs1935062 - rs947267 - rs954581(C-G-A-C-T), rs1935058 - rs2391191 - rs1935062 - rs947267 - rs954581(T-G-A-A-T)	These new results provide further evidence, in an independent sample, for an association between BPAD and genetic variation in the vicinity of the genes G72 and G30.	Positive	Comment on Study
Schumacher, J.,2004	SNP: rs1341402, rs1935062, rs2391191, rs778294 Haplotype: M12 - M15 - M23 - M24(T-A-C-T), M12 - M15 - M23 - M24(T-A-T-A), M12 - M15 - M23 - M24(C-G-C-T), M12 - M15 - M23 - M24(C-G-T-A) Other variant: DAOA_M12, DAOA_M24, DAOA_M23	The association of variation at G72 with schizophrenia as well as BPAD provides molecular support for the hypothesis that these two major psychiatric disorders share some of their etiologic background.	Positive	Comment on Study

Region: chr13:105465867..105491034 View in gBrowse