SNP Report

Basic Info

Name	rs7825588 dbSNP Ensembl
Location	chr8:32646882 - 32646882(1)
Variant Alleles	G/A
Ancestral Allele	G
Minor Allele	A
Minor Allele Frequence	0.0840655
Functional Annotation	intron_variant; non_coding_transcript_variant; upstream_gene_variant.
Consequence to Transcript	intron_variant(ENST00000287842, ENST00000356819, ENST00000405005, ENST00000518104, ENST00000518206, ENST00000519301, ENST00000520407, ENST00000521670, ENST00000522569, ENST00000523079, ENST00000523534, ENST00000631040); non_coding_transcript_variant(ENST00000522569); upstream_gene_variant(ENST00000520502, ENST00000523041)
No. of Studies	1 (Positive: 0; Negative: 1; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	NO

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Pedrosa, E.,2009	G/A		BD vs. controls: allele frequency, X² = 0.52, P-v...... BD vs. controls: allele frequency, X² = 0.52, P-value = 0.47; genotype distribution, X²= 0.52, P-value = 0.77; HWE controls, P-value = 0.69; BD, P-value = 1.0. More...	No significant association was observed. No significant association was observed.	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
NRG1	neuregulin 1	8p12	15(10/5/0)

SNPs in LD with rs7825588 (count: 0) View in gBrowse (chr8:32646882..32646882 )

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Pedrosa, E.,2009	SZ vs. controls: allele frequency, X²= 0.16, P-value = 0.68; genotype distribution, X² = 7.32, P-value = 0.03; HWE controls, P-value = 0.08; SZ, P-value =0.04.	Significant Significant association was observed in genotype distribution.	Positive

Overlap with MDD from cross-disorder studies (count: 0)