BDgene

Study Report

Basic Info
Reference
Citation Saito, T., et al. (2014). "Replication and cross-phenotype study based upon schizophrenia GWASs data in the Japanese population: Support for association of MHC region with psychosis." Am J Med Genet B Neuropsychiatr Genet.
Disease Type Bipolar Disorder & Schizophrenia
Study Design case-control
Study Type Genome-wide association study
Sample Size 1032 SCZ, 1012 BD(BD typeI=621, BD typeII=380, schizoaffective disorder [SA]=7, BD type information not available=4) and 993 controls.
SNP/Region/Marker Size 51 SNPs
Predominant Ethnicity Mongloid
Population Japanese
Gender The first-set: BD: 51.8% female subjects of 1,012 patients; SZ: 48.3% female subjects of 1,032 patients; Controls: 51.1% female subjects of 993 healthy controls. The replication set: BD: 54.6% female subjects of 821 patients, SD=14.4; SZ: 45.1% female subjects of 1,808 patients; Controls: 57.2% female subjects of 2,321 healthy controls.
Age Group adults : The first-set: BD: mean age=50.7, SD=14.3; SZ: mean age=46.8, SD=14.8; Controls: mean age=49.7, SD=14.0. The replication set: BD: mean age=48.2, SD=14.4; SZ: mean age=49.8, SD=14.8; Controls: mean age=42.3, SD=14.2.

Detail Info

Genetic factors reported by this study for BD
SNPs reported by this study for BD (count: 9)

Genes reported by this study for BD (count: 9)

Genetic factors reported by this study for SZ and/or MDD
SNPs reported by this study for SZ/MDD
Disease SNP Related Gene(s) Statistical Values Description Result Category
SZ rs7759855 ZSCAN31 First-set screening: P-valuecorrected=0.12, P-value=0.00292, OR=1.48, 95%CI=1.14-1.91; Second-set replication: P-valuecorrected=0.0322, P-value=0.0161, OR=1.23, 95%CI=1.04-1.46. Current study (first-set screening_second-set replication): P-value=6.65*10-4, I2=25.4; PGC+current study: P-value=5.02*10-4, I2=0.0. Significant association was observed. Positive
SZ rs1233710 ZKSCAN4 First-set screening: P-valuecorrected=1, P-value=0.534, OR=1.04, 95%CI=0.91-1.19 No significant association was observed. Negative
SZ rs10489202 MPC2 DCAF6 First-set screening: P-valuecorrected=1, P-value=0.0267, OR=1.24, 95%CI=1.02-1.49 Significant association was observed. Positive
SZ rs1060041 DCAF6 First-set screening: P-valuecorrected=1, P-value=0.0481, OR=1.21, 95%CI=1.00-1.46 Significant association was observed. Positive
SZ rs4775413 CYCSP38 First-set screening: P-valuecorrected=0.65, P-value=0.0156, OR=1.18, 95%CI=1.03-1.34 Significant association was observed. Positive
SZ rs7004633 MMP16 First-set screening: P-valuecorrected=0.65, P-value=0.0155, OR=0.83, 95%CI=0.71-0.96 Significant association was observed. Positive
SZ rs2021722 TRIM26 First-set screening: P-valuecorrected=0.32, P-value=0.00759, OR=0.76, 95%CI=0.62-0.93 Significant association was observed. Positive
SZ rs1736913 HLA-F-AS1 HLA-F First-set screening: P-valuecorrected=0.89, P-value=0.0212, OR=1.19, 95%CI=1.03-1.39; Second-set replication: P-valuecorrected=0.0866, P-value=0.0433, OR=1.11, 95%CI=1.00-1.23. Current study (first-set screening_second-set replication): P-value=0.00800, I2=0.0; PGC+current study: P-value=0.00445, I2=59.7 Significant association was observed. Positive
SZ rs6927023 GPX6 First-set screening: P-valuecorrected=0.16, P-value=0.00384, OR=1.46, 95%CI=1.13-1.88 Significant association was observed. Positive

Genes reported by this study for SZ/MDD
Disease Gene Description Result Category
SZ HLA-F-AS1 The associated SNP in this gene showed significant association with SZ. Positive
SZ CYCSP38 The associated SNP in this gene showed significant association with SZ. Positive
SZ TRIM26 The associated SNP in this gene showed significant association with SZ. Positive
SZ DCAF6 The associated SNP in this gene showed significant association with SZ. Positive
SZ ZKSCAN4 The associated SNP in this gene showed no significant association with SZ. Negative
SZ MMP16 The associated SNP in this gene showed significant association with SZ. Positive
SZ MPC2 The associated SNP in this gene showed significant association with SZ. Positive
SZ GPX6 The associated SNP in this gene showed no association with SZ. Positive
SZ ZSCAN31 The associated SNP in this gene showed significant association with SZ. Positive