SNP Report

Basic Info

Name	rs12539410 dbSNP Ensembl
Location	chr7:132381325 - 132381325(1)
Variant Alleles	G/C
Ancestral Allele	G
Minor Allele	C
Minor Allele Frequence	0.0976438
Functional Annotation	downstream_gene_variant; intron_variant.
Consequence to Transcript	downstream_gene_variant(ENST00000423507); intron_variant(ENST00000321063, ENST00000359827)
No. of Studies	1 (Positive: 0; Negative: 1; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	YES

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Huang, J.,2010	C/G		Omnibus GWAS Test: P-value > 5E-05 Omnibus GWAS Test: P-value > 5E-05	No significant association was observed in BD. No significant association was observed in BD.	Negative

SNP related genes (count: 2)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
PLXNA4	plexin A4	7q32.3	Mapped by Literature SNP
CHCHD3	coiled-coil-helix-coiled-coil-helix domain containing 3	7q33	1(0/1/0)

SNPs in LD with rs12539410 (count: 0) View in gBrowse (chr7:132381325..132381325 )

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Huang, J.,2010	Omnibus GWAS Test:P-value > 5E-05	No significant association was observed.	Negative

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Huang, J.,2010	Omnibus GWAS Test:P-value = 0.00000474, best-fit model is Depressive disorders	Suggestive association was found.	Trend