Study Report
Basic Info
| Reference |
Jamra, R. A., 2006 (b) PMID: 16691125
|
| Citation |
Jamra, R. A., A. W. Villela, et al. (2006). "No association between genetic variants at the GLYT2 gene and bipolar affective disorder and schizophrenia." Psychiatr Genet 16(3): 91.
|
| Disease Type |
Bipolar Disorder & Schizophrenia |
| Study Design |
case-control |
| Study Type |
Candidate-gene association study |
| Sample Size |
308 BPAD patients, 328 schizophrenia patients and 307 controls |
| SNP/Region/Marker Size |
5 variants |
| Predominant Ethnicity |
Caucasian |
| Population |
German |
| Age Group |
adults
|
Detail Info
| Sample Diagnosis |
DSM-IV |
| Sample Status |
All individuals were of German descent. Lifetime 'best estimate' diagnoses according to the Diagnostic and Statistical Manual of Mental Disorder-IV criteria were based on multiple sources of information including a structured interview (SCID I). |
| Technique |
genotyping |
| Result Summary |
In the single-marker analysis, none of the analyzed variants revealed a significant association with disease. Numbers of common alleles/rare alleles for controls, BPAD, and schizophrenia, respectively, were as follows: rs2241940: 415/193, 388/214, and 354/206; rs2289683: 607/1, 594/4, and 622/2; rs3740871: 390/166, 427/171, and 449/187. SLC6A5-20 showed 13 different alleles. The haplotype analyses did not improve the results; global P-values of the five-marker haplotype analysis were 0.636 for schizophrenia and 0.407 for BPAD (corrected for multiple analyses). Their results do not suggest that a common genetic variant at the GLYT2 locus contributes to BPAD and/or schizophrenia in patients of German descent. |
Genetic factors reported by this study for BD
SNPs reported by this study for BD (count: 4)
| SNP |
Related Gene(s) |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result Category |
| rs2000959 |
SLC6A5
|
|
|
data not shown
|
In the single-marker analysis, none of the analyzed variants......
In the single-marker analysis, none of the analyzed variants revealed a significant association with disease.
More...
|
Negative
|
| rs2241940 |
SLC6A5
|
|
|
data not shown
|
In the single-marker analysis, none of the analyzed variants......
In the single-marker analysis, none of the analyzed variants revealed a significant association with disease.
More...
|
Negative
|
| rs2289683 |
SLC6A5
|
|
|
data not shown
|
In the single-marker analysis, none of the analyzed variants......
In the single-marker analysis, none of the analyzed variants revealed a significant association with disease.
More...
|
Negative
|
| rs1805091 |
SLC6A5
|
|
|
data not shown
|
In the single-marker analysis, none of the analyzed variants......
In the single-marker analysis, none of the analyzed variants revealed a significant association with disease.
More...
|
Negative
|
Other variants reported by this study for BD (count: 1)
| Variant Name |
Related Gene |
Type |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result Category |
| SLC6A5 AC-tandem-repeat |
SLC6A5 |
microsatellite |
|
|
data not shown
|
In the single-marker analysis, none of the analyzed variants......
In the single-marker analysis, none of the analyzed variants revealed a significant association with disease.
More...
|
Negative
|
Genes reported by this study for BD (count: 1)
| Gene |
Statistical Values/Author Comments |
Result Category |
| SLC6A5 |
Our results do not suggest that a common genetic variant at the GLYT2 locus contributes to BPAD and/......
Our results do not suggest that a common genetic variant at the GLYT2 locus contributes to BPAD and/or schizophrenia in patients of German descent.
More...
|
Negative
|
Genetic factors reported by this study for SZ and/or MDD
