
Search SNP
Search Gene
Search CNV
Search Haplotype
Search Other Variant
Search Region
Search Pathway
Search Study
Study Report
Comment on Study | View All Comments on Study |
Reference | Kishi, T., 2008 (a) PMID: 18085546 |
---|---|
Citation | Kishi, T., M. Ikeda, et al. (2008). "No association between prostate apoptosis response 4 gene (PAWR) in schizophrenia and mood disorders in a Japanese population." Am J Med Genet B Neuropsychiatr Genet 147B(4): 531-534. |
Disease Type | Bipolar Disorder & Schizophrenia & Major Depressive Disorder |
Study Design | case-control |
Study Type | Candidate-gene association study |
Sample Size | schizophrenia: 556 cases. Bipolar disorder (BP): 150 cases (93 patients with Bipolar I disorder and 57 patients with Bipolar II disorder). Major depressive disorder (MDD): 312 cases. 466 controls |
SNP/Region/Marker Size | 5 SNPs |
Predominant Ethnicity | Mongloid |
Population | Japanese |
Gender | schizophrenia (289 males and 267 females), MDD (155 males and 157 females), BP (76 males and 74 females) and controls (243 males and 223 females). |
Age Group | adults : SZ patients: males mean age=42.84 (SD=14.58) years, females mean age=45.13 (SD=14.9) years; MDD patients: males mean age=44.49 (SD=14.09) years, females mean age=50.43 (SD=17.12) years; BP patients: males mean age=46.58 (SD=12.55) years, females mean age=45.05 (SD=14.69) years; Controls: males mean age=34.59 (SD=12.58) years, females mean age=36.16 (SD=15.54) years; |
Sample Diagnosis | DSM-IV |
---|---|
Technique | genotyping |
Statistical Method | Genotype deviation from the Hardy-Weinberg equilibrium (HWE) was evaluated by chi-square test (SAS/Genetics, release 8.2, SAS Japan Inc, Tokyo, Japan). Marker-trait association was evaluated by the X2 test (allele and genotype-wise analyses), and the log-likelihood test (haplotype-wise analysis,where the haplotype frequencieswere estimatedwith the Expectation-Maximization algorithm) (SAS/Genetics, release 8.2).To control inflationof the type I error rate, we used a recently developed software program, SNPSpD, which can reflect the correlation of markers (LD) on corrected P-values [Nyholt, 2004]. Power calculation was performed using a statistical program prepared by Ohashi et al. [2001]. The significance level for all statistical tests was 0.05. |
Result Summary | No significant association was obtained found with schizophrenia or MDD or BP. We found a significant association of one tagging SNP with BP in a genotype-wise analysis (P=0.0396); however, this might be resulted from type I error due to multiple testing (P=0.158 after SNPSpD correction). |
SNP | Related Gene(s) | Allele Change | Risk Allele | Statistical Values | Author Comments | Result Category |
---|---|---|---|---|---|---|
rs2463169 | PAWR | G > A | Hardy-Weinberg equilibrium P value=0.744, genotypic P value=0.317, allelic P value=0.502 for bipolor disorder compared with controls. | Negative | ||
rs2400546 | PAWR | A > T | Hardy-Weinberg equilibrium P value=0.403, genotypic P value=0.953, allelic P value=0.717 for bipolor disorder compared with controls. | Negative | ||
rs17005769 | PAWR | G > A | Hardy-Weinberg equilibrium P value=0.441, genotypic P value=0.121, allelic P value=0.205 for bipolor disorder compared with controls. | Negative | ||
rs7305141 | PAWR | A > G | Hardy-Weinberg equilibrium P value=0.168, genotypic P value=0.0962, allelic P value=0.163 for bipolor disorder compared with controls. | Negative | ||
rs4842318 | PAWR | C > T | Hardy-Weinberg equilibrium P value=0.167, genotypic P value=0.128, allelic P value=0.0396 for bipolor disorder compared with controls, corrected P-value = 0.158 | showed a significant association with BP in a genotype-wise ...... showed a significant association with BP in a genotype-wise analysis. Nevertheless, this significance may be a result of type I error due to multiple testing. More... | Negative |
Markers | Haplotype | Related Gene(s)/Region(s) | Statistical Values | Author Comments | Result Category |
---|---|---|---|---|---|
rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141 | ATGCA | PAWR | P-value = 0.994 for bipolor disorder | Negative | |
rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141 | GAACG | PAWR | P-value = 0.229 for bipolor disorder | Negative | |
rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141 | AAGCA | PAWR | P-value = 0.0720 for bipolor disorder | Negative | |
rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141 | GAGCG | PAWR | P-value = 0.423 for bipolor disorder | Negative | |
rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141 | PAWR | Global P-value = 0.158 for bipolor disorder | Negative | ||
rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141 | GAGTA | PAWR | P-value = 0.109 for bipolor disorder | Negative |
Gene | Statistical Values/Author Comments | Result Category |
---|---|---|
PAWR | Our results suggest that the PAWR does not play a major role in schizophrenia or mood disorders in t...... Our results suggest that the PAWR does not play a major role in schizophrenia or mood disorders in the Japanese population. More... | Negative |
Disease | SNP | Related Gene(s) | Statistical Values | Description | Result Category |
---|---|---|---|---|---|
SZ | rs17005769 | PAWR | Hardy-Weinberg equilibrium P value=0.125, genotypic P value=0.254, allelic P value=0.414 for schizophrenia compared with controls. | No association was detected with schizophrenia or MDD in allele/genotype-wise analyses. | Negative |
SZ | rs2463169 | PAWR | Hardy-Weinberg equilibrium P value=0.329, genotypic P value=0.872, allelic P value=0.517 for schizophrenia compared with controls. | No association was detected with schizophrenia or MDD in allele/genotype-wise analyses. | Negative |
SZ | rs2400546 | PAWR | Hardy-Weinberg equilibrium P value=0.106, genotypic P value=0.786, allelic P value=0.474 for schizophrenia compared with controls. | No association was detected with schizophrenia or MDD in allele/genotype-wise analyses. | Negative |
SZ | rs7305141 | PAWR | Hardy-Weinberg equilibrium P value=0.0556, genotypic P value=0.986, allelic P value=0.237 for schizophrenia compared with controls. | No association was detected with schizophrenia or MDD in allele/genotype-wise analyses. | Negative |
SZ | rs4842318 | PAWR | Hardy-Weinberg equilibrium P value=0.388, genotypic P value=0.822, allelic P value=0.161 for schizophrenia compared with controls. | No association was detected with schizophrenia or MDD in allele/genotype-wise analyses. | Negative |
MDD | rs17005769 | PAWR | Hardy-Weinberg equilibrium P value=0.313, genotypic P value=0.21, allelic P value=0.261 for MDD compared with controls. | No association was detected with schizophrenia or MDD in allele/genotype-wise analyses. | Negative |
MDD | rs2463169 | PAWR | Hardy-Weinberg equilibrium P value=0.225, genotypic P value=0.402, allelic P value=0.608 for MDD compared with controls. | No association was detected with schizophrenia or MDD in allele/genotype-wise analyses. | Negative |
MDD | rs2400546 | PAWR | Hardy-Weinberg equilibrium P value=0.408, genotypic P value=0.453, allelic P value=0.656 for MDD compared with controls. | No association was detected with schizophrenia or MDD in allele/genotype-wise analyses. | Negative |
MDD | rs7305141 | PAWR | Hardy-Weinberg equilibrium P value=0.372, genotypic P value=0.0855, allelic P value=0.205 for MDD compared with controls. | No association was detected with schizophrenia or MDD in allele/genotype-wise analyses. | Negative |
MDD | rs4842318 | PAWR | Hardy-Weinberg equilibrium P value=0.897, genotypic P value=0.726, allelic P value=0.439 for MDD compared with controls. | No association was detected with schizophrenia or MDD in allele/genotype-wise analyses. | Negative |
Disease | Markers | Haplotype | Related Gene(s)/Region(s) | Statistical Values | Description | Result Category |
---|---|---|---|---|---|---|
SZ | rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141 | PAWR | Global P-value = 0.142 for SZ | Negative | ||
SZ | rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141 | GAGTA | PAWR | P-value = 0.572 for SZ | Negative | |
SZ | rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141 | GAACG | PAWR | P-value = 0.078 for SZ | Negative | |
SZ | rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141 | ATGCA | PAWR | P-value = 0.910 for SZ | Negative | |
SZ | rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141 | GAGCG | PAWR | P-value = 0.247 for SZ | Negative | |
SZ | rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141 | AAGCA | PAWR | P-value = 0.621 for SZ | Negative | |
MDD | rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141 | PAWR | Global P-value = 0.143 for MDD | Negative | ||
MDD | rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141 | GAGTA | PAWR | P-value = 0.771 for MDD | Negative | |
MDD | rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141 | GAACG | PAWR | P-value = 0.095 for MDD | Negative | |
MDD | rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141 | ATGCA | PAWR | P-value = 0.577 for MDD | Negative | |
MDD | rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141 | GAGCG | PAWR | P-value = 0.744 for MDD | Negative | |
MDD | rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141 | AAGCA | PAWR | P-value = 0.752 for MDD | Negative |
Disease | Gene | Description | Result Category |
---|---|---|---|
SZ | PAWR | Negative | |
MDD | PAWR | Our results suggest that the PAWR does not play a major role in mood disorders in the Japanese population. | Negative |
Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
Acknowledgements
To view this website normally, please make sure to allow Flash to run from the local filesystem in the security settings panel.
Last update: March 31, 2016