BDgene

Study Report

Basic Info
Reference
Citation Kishi, T., M. Ikeda, et al. (2008). "No association between prostate apoptosis response 4 gene (PAWR) in schizophrenia and mood disorders in a Japanese population." Am J Med Genet B Neuropsychiatr Genet 147B(4): 531-534.
Disease Type Bipolar Disorder & Schizophrenia & Major Depressive Disorder
Study Design case-control
Study Type Candidate-gene association study
Sample Size schizophrenia: 556 cases. Bipolar disorder (BP): 150 cases (93 patients with Bipolar I disorder and 57 patients with Bipolar II disorder). Major depressive disorder (MDD): 312 cases. 466 controls
SNP/Region/Marker Size 5 SNPs
Predominant Ethnicity Mongloid
Population Japanese
Gender schizophrenia (289 males and 267 females), MDD (155 males and 157 females), BP (76 males and 74 females) and controls (243 males and 223 females).
Age Group adults : SZ patients: males mean age=42.84 (SD=14.58) years, females mean age=45.13 (SD=14.9) years; MDD patients: males mean age=44.49 (SD=14.09) years, females mean age=50.43 (SD=17.12) years; BP patients: males mean age=46.58 (SD=12.55) years, females mean age=45.05 (SD=14.69) years; Controls: males mean age=34.59 (SD=12.58) years, females mean age=36.16 (SD=15.54) years;

Detail Info

Genetic factors reported by this study for BD
SNPs reported by this study for BD (count: 5)

Haplotypes reported by this study for BD (count: 6)

Genes reported by this study for BD (count: 1)

Genetic factors reported by this study for SZ and/or MDD
SNPs reported by this study for SZ/MDD
Disease SNP Related Gene(s) Statistical Values Description Result Category
SZ rs17005769 PAWR Hardy-Weinberg equilibrium P value=0.125, genotypic P value=0.254, allelic P value=0.414 for schizophrenia compared with controls. No association was detected with schizophrenia or MDD in allele/genotype-wise analyses. Negative
SZ rs2463169 PAWR Hardy-Weinberg equilibrium P value=0.329, genotypic P value=0.872, allelic P value=0.517 for schizophrenia compared with controls. No association was detected with schizophrenia or MDD in allele/genotype-wise analyses. Negative
SZ rs2400546 PAWR Hardy-Weinberg equilibrium P value=0.106, genotypic P value=0.786, allelic P value=0.474 for schizophrenia compared with controls. No association was detected with schizophrenia or MDD in allele/genotype-wise analyses. Negative
SZ rs7305141 PAWR Hardy-Weinberg equilibrium P value=0.0556, genotypic P value=0.986, allelic P value=0.237 for schizophrenia compared with controls. No association was detected with schizophrenia or MDD in allele/genotype-wise analyses. Negative
SZ rs4842318 PAWR Hardy-Weinberg equilibrium P value=0.388, genotypic P value=0.822, allelic P value=0.161 for schizophrenia compared with controls. No association was detected with schizophrenia or MDD in allele/genotype-wise analyses. Negative
MDD rs17005769 PAWR Hardy-Weinberg equilibrium P value=0.313, genotypic P value=0.21, allelic P value=0.261 for MDD compared with controls. No association was detected with schizophrenia or MDD in allele/genotype-wise analyses. Negative
MDD rs2463169 PAWR Hardy-Weinberg equilibrium P value=0.225, genotypic P value=0.402, allelic P value=0.608 for MDD compared with controls. No association was detected with schizophrenia or MDD in allele/genotype-wise analyses. Negative
MDD rs2400546 PAWR Hardy-Weinberg equilibrium P value=0.408, genotypic P value=0.453, allelic P value=0.656 for MDD compared with controls. No association was detected with schizophrenia or MDD in allele/genotype-wise analyses. Negative
MDD rs7305141 PAWR Hardy-Weinberg equilibrium P value=0.372, genotypic P value=0.0855, allelic P value=0.205 for MDD compared with controls. No association was detected with schizophrenia or MDD in allele/genotype-wise analyses. Negative
MDD rs4842318 PAWR Hardy-Weinberg equilibrium P value=0.897, genotypic P value=0.726, allelic P value=0.439 for MDD compared with controls. No association was detected with schizophrenia or MDD in allele/genotype-wise analyses. Negative

Haplotypes reported by this study for SZ/MDD
Disease Markers Haplotype Related Gene(s)/Region(s) Statistical Values Description Result Category
SZ rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141 PAWR Global P-value = 0.142 for SZ Negative
SZ rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141 GAGTA PAWR P-value = 0.572 for SZ Negative
SZ rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141 GAACG PAWR P-value = 0.078 for SZ Negative
SZ rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141 ATGCA PAWR P-value = 0.910 for SZ Negative
SZ rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141 GAGCG PAWR P-value = 0.247 for SZ Negative
SZ rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141 AAGCA PAWR P-value = 0.621 for SZ Negative
MDD rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141 PAWR Global P-value = 0.143 for MDD Negative
MDD rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141 GAGTA PAWR P-value = 0.771 for MDD Negative
MDD rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141 GAACG PAWR P-value = 0.095 for MDD Negative
MDD rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141 ATGCA PAWR P-value = 0.577 for MDD Negative
MDD rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141 GAGCG PAWR P-value = 0.744 for MDD Negative
MDD rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141 AAGCA PAWR P-value = 0.752 for MDD Negative

Genes reported by this study for SZ/MDD
Disease Gene Description Result Category
SZ PAWR Negative
MDD PAWR Our results suggest that the PAWR does not play a major role in mood disorders in the Japanese population. Negative