SNP Report

Basic Info

Name	rs3757440 dbSNP Ensembl
Location	chr7:2233301 - 2233301(1)
Variant Alleles	A/G
Ancestral Allele	A
Minor Allele	G
Minor Allele Frequence	0.384784
Functional Annotation	downstream_gene_variant; upstream_gene_variant.
Consequence to Transcript	downstream_gene_variant(ENST00000242257, ENST00000407040, ENST00000440306, ENST00000467199, ENST00000486040); upstream_gene_variant(ENST00000265854, ENST00000399654, ENST00000402746, ENST00000406869, ENST00000429779, ENST00000455998)
No. of Studies	1 (Positive: 1; Negative: 0; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	NO

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Andreassen OA, 2013	A/G		Conjunction FDR; pleiotropic loci in SCZ and BD: FDR=0.031 f...... Conjunction FDR; pleiotropic loci in SCZ and BD: FDR=0.031 for BD and SZ, Z-score=3.49 for BD More...	This SNP is with conjunction FDR<0.11 with schizophrenia and...... This SNP is with conjunction FDR<0.11 with schizophrenia and bipolar disorder considered jointly. More...	Positive

SNP related genes (count: 2)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
FTSJ2	FtsJ RNA methyltransferase homolog 2 (E. coli)	7p22	Mapped by Literature SNP
MAD1L1	MAD1 mitotic arrest deficient-like 1 (yeast)	7p22	5(1/2/2)

SNPs in LD with rs3757440 (count: 0) View in gBrowse (chr7:2233301..2233301 )

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Andreassen OA, 2013	Conjunction FDR; pleiotropic loci in SCZ and BD: FDR=0.031 for BD and SZ, Z-score=3.425 for SZ	This SNP is with conjunction FDR<0.11 with schizophrenia and bipolar disorder considered jointly.	Positive

Overlap with MDD from cross-disorder studies (count: 0)