BDgene

Study Report

Basic Info
Reference
Citation Bass, N. J., S. R. Datta, et al. (2009). Evidence for the association of the DAOA (G72) gene with schizophrenia and bipolar disorder but not for the association of the DAO gene with schizophrenia. Behav Brain Funct 5: 28.
Disease Type Bipolar Disorder & Schizophrenia
Study Design case-control
Study Type Candidate-gene association study
Sample Size 431 patients with schizophrenia, 303 patients with bipolar disorder and 442 ancestrally matched supernormal controls
SNP/Region/Marker Size 14 SNPs
Predominant Ethnicity Caucasian
Population British

Detail Info

Genetic factors reported by this study for BD
SNPs reported by this study for BD (count: 14)

Genes reported by this study for BD (count: 1)

Genetic factors reported by this study for SZ and/or MDD
SNPs reported by this study for SZ/MDD
Disease SNP Related Gene(s) Statistical Values Description Result Category
SZ rs778294 DAOA DAOA-AS1 chi-squared tests:for SCZ, allele, X2(1 d.f.)=0.141, P-value = 0.707 No significant association was observed. Negative
SZ rs947267 DAOA DAOA-AS1 chi-squared tests:for SCZ, allele, X2(1 d.f.)=0.203, P-value = 0.652 No significant association was observed. Negative
SZ rs3918346 DAO DAOA chi-squared tests:for SCZ, allele, X2(1 d.f.)=0.976, P-value = 0.323 No significant association was observed. Negative
SZ rs778293 DAOA chi-squared tests:for SCZ, allele, X2(1 d.f.)=0.93, P-value = 0.335 No significant association was observed. Negative
SZ rs3916967 DAOA DAOA-AS1 chi-squared tests:for SCZ, allele, X2(1 d.f.)=3.675, P-value = 0.055 No significant association was observed. Negative
SZ rs3918342 DAOA chi-squared tests:for SCZ, allele, X2(1 d.f.)=5.824, P-value = 0.016 Significant association was observed in allelic association in SCZ. Positive
SZ rs3741775 DAO DAOA chi-squared tests:for SCZ, allele, X2(1 d.f.)=0.587, P-value = 0.444 No significant association was observed. Negative
SZ rs3916965 DAOA chi-squared tests:for SCZ, allele, X2(1 d.f.)=2.101, P-value = 0.147 No significant association was observed. Negative
SZ rs2111902 DAO DAOA chi-squared tests:for SCZ, allele, X2(1 d.f.)=0.025, P-value = 0.875 No significant association was observed. Negative
SZ rs2391191 DAOA DAOA-AS1 chi-squared tests:for SCZ, allele, X2(1 d.f.)=0.521, P-value = 0.47 No significant association was observed. Negative
SZ rs1421292 DAOA chi-squared tests:for SCZ, allele, X2(1 d.f.)=3.499, P-value = 0.062 No significant association was observed. Negative

Genes reported by this study for SZ/MDD
Disease Gene Description Result Category
SZ DAOA Our results provide some support for a role for DAOA in susceptibility to schizophrenia and bipolar disorder. Positive
SZ DAO Negative