SNP Report

Basic Info

Name	rs12476147 dbSNP Ensembl
Location	chr2:184936178 - 184936178(1)
Variant Alleles	A/T
Ancestral Allele	T
Minor Allele	A
Minor Allele Frequence	0.380791
Functional Annotation	missense_variant. Polyphen Annotation: benign(ENST00000302277, ENST00000613975) SIFT Annotation: tolerated(ENST00000302277, ENST00000613975)
Consequence to Transcript	missense_variant(ENST00000302277, ENST00000613975)
No. of Studies	1 (Positive: 0; Negative: 1; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	NO

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Guella, I., 2013	A/T		P-value=0.868, X²=0.03 P-value=0.868, X²=0.03	No significant association was reported. No significant association was reported.	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
ZNF804A	zinc finger protein 804A	2q32.1	6(3/3/0)

SNPs in LD with rs12476147 (count: 0) View in gBrowse (chr2:184936178..184936178 )

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Guella, I., 2013	P-value=0.053, X²=3.75, P-value = 0.026, one tailed	The minor A allele of the rs12476147 SNP, located in the exon 4 of the ZNF804A gene, showed association with an increased risk of SZ (p = 0.026, one tailed) using DFAM..	Negative

Overlap with MDD from cross-disorder studies (count: 0)