SNP Report

Basic Info

Name	rs3786282 dbSNP Ensembl
Location	chr18:12013183 - 12013183(1)
Variant Alleles	A/C
Ancestral Allele	C
Minor Allele	C
Minor Allele Frequence	0.491214
Functional Annotation	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant.
Consequence to Transcript	downstream_gene_variant(ENST00000588863, ENST00000625802); intron_variant(ENST00000269159, ENST00000383376, ENST00000586230, ENST00000588167, ENST00000588752, ENST00000588927, ENST00000589238, ENST00000590107, ENST00000590138); NMD_transcript_variant(ENST00000383376, ENST00000586230, ENST00000590107, ENST00000590138); non_coding_transcript_variant(ENST00000588167, ENST00000588752)
No. of Studies	2 (Positive: 0; Negative: 2; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	NO

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Ohnishi, T., 2007	A/C		Fisher's exact test, allelic P-value = 0.615, genotypic P-va...... Fisher's exact test, allelic P-value = 0.615, genotypic P-value = 0.865 More...		Negative
Dimitrova, A.,2005	A/C		Allelic association: P-value(TDT)=0.46 in BG trios; P-value(...... Allelic association: P-value(TDT)=0.46 in BG trios; P-value(TDT)=0.92 in UK trios; P-value = 0.43 in UK case/control sample More...	No significant association was observed. No significant association was observed.	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
IMPA2	inositol(myo)-1(or 4)-monophosphatase 2	18p11.2	4(2/2/0)

SNPs in LD with rs3786282 (count: 2) View in gBrowse (chr18:12011206..12013183 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Literature-origin SNPs with LD	Functional Annotation	r²[population]
rs619525		downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant	0.896[CEU]; 0.951[CHB]; 1.0[JPT]
rs7235476		downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant	0.899[CEU]; 1.0[CHB]; 0.977[CHD]; 1.0[JPT]

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Ohnishi, T., 2007	Fisher's exact test, allelic P-value = 0.965, genotypic P-value = 1		Negative

Overlap with MDD from cross-disorder studies (count: 0)