BDgene

SNP Report

Basic Info
Name rs37022 dbSNP Ensembl
Location chrCHR_HSCHR5_3_CTG1:1413658 - 1413658(-1)
Variant Alleles A/T
Ancestral Allele A
Minor Allele T
Minor Allele Frequence 0.355631
Functional Annotation intron_variant; non_coding_transcript_variant; downstream_gene_variant.
Consequence to Transcript intron_variant(ENST00000270349, ENST00000511750); non_coding_transcript_variant(ENST00000511750); downstream_gene_variant(ENST00000626610, ENST00000621716)
No. of Studies 3 (Positive: 1; Negative: 2; Trend: 0)
Source Literature
Overlap with SZ? YES
Overlap with MDD? NO

SNP related studies (count: 3)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Shi, J., 2008 (b) A/T A Allelic association of neurotransmission systems genes with ...... Allelic association of neurotransmission systems genes with bipolar disorder: TDT P-value = 0.0371, Gene-wide P-value = 0.2108 (P values were based on permutation for all SNPs in each gene). More... Positive
Pinsonneault, J. K.,2011 Stanley sample: allele, X2 P-value = 0.75, Fisher...... Stanley sample: allele, X2 P-value = 0.75, Fisher's exact P-value = 0.85, OR=1.13, 95%CI=0.5-2.3 for BD; X2 P-value = 0.81, Fisher's exact P-value = 0.86OR=0.91 for BD More... No significant association was observed. No significant association was observed. Negative
Mick, E., 2008 T TDT X2(df=1)=1.14, P-value = 0.309, OR (95% CI)=1...... TDT X2(df=1)=1.14, P-value = 0.309, OR (95% CI)=1.06(0.72-1.57) More... Negative

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 5p15.3 11(5/6/0)


Overlap with SZ from cross-disorder studies (count: 1)
Reference Statistical Result Description Result Category
Pinsonneault, J. K.,2011 Stanley sample:allele, X2 P-value = 0.81, Fisher's exact P-value = 0.86OR=0.91 for SZ No significant association was observed. Negative

Overlap with MDD from cross-disorder studies (count: 0)