Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	TRIM26
Previous Symbol	ZNF173
Symbol Alias	RNF95
Approved Name	tripartite motif containing 26
Previous Name	tripartite motif-containing 26
Location	6p21.3
Position	chr6:30184455-30213427, -1
External Links	HGNC: 12962 Entrez Gene: 7726 Ensembl: ENSG00000234127 UCSC: uc003npt.3
No. of Studies	2 (Positive: 2; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 2)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Saito T., 2014	SNP: rs2021722	The associated SNP in this gene showed significant association with BD.	Positive	Comment on Study
Hamshere, M. L.,2012	SNP: rs2021722	We also provide strong evidence for overlap in genetic risk between schizophrenia and bipolar disorder.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 12)

GO terms by PBA (count: 2)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0045087	innate immune response	biological process	IDA[18248090]	49
GO:0003677	DNA binding	molecular function	NAS[8530076]	83

GO terms by database search (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0019221	cytokine-mediated signaling pathway	biological process	TAS	23
GO:0005829	cytosol	cellular component	TAS	223
GO:1902187	negative regulation of viral release from host cell	biological process	IDA[18248090]	1
GO:0008270	zinc ion binding	molecular function	IEA	77
GO:0046597	negative regulation of viral entry into host cell	biological process	IDA[18248090]	1
GO:0005575	cellular_component	cellular component	ND	19
GO:0046872	metal ion binding	molecular function	NAS[8530076]	115
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity	biological process	IDA[23077300]	11
GO:0060333	interferon-gamma-mediated signaling pathway	biological process	TAS	10
GO:0005515	protein binding	molecular function	IPI[25416956]	563

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 16)

Literature-origin SNPs (count: 2)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs2021722	chrCHR_HSCHR6_MHC_SSTO_CTG1:30196705 - 30196705(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant	2(2/0/0)
rs2523722	chrCHR_HSCHR6_MHC_SSTO_CTG1:30187846 - 30187846(1)	downstream_gene_variant; intron_variant	1(1/0/0)

LD-proxies (count: 14)

rs_ID	Location	Functional Annotation
rs2523721	chrCHR_HSCHR6_MHC_SSTO_CTG1:30188839 - 30188839(1)	downstream_gene_variant; synonymous_variant
rs2517614	chrCHR_HSCHR6_MHC_SSTO_CTG1:30186528 - 30186528(1)	downstream_gene_variant; intron_variant
rs2517610	chrCHR_HSCHR6_MHC_SSTO_CTG1:30192853 - 30192853(1)	intron_variant; non_coding_transcript_variant
rs2517611	chrCHR_HSCHR6_MHC_SSTO_CTG1:30191900 - 30191900(1)	intron_variant; non_coding_transcript_variant
rs2284168	chrCHR_HSCHR6_MHC_SSTO_CTG1:30194807 - 30194807(1)	intron_variant; non_coding_transcript_variant
rs28360013	chrCHR_HSCHR6_MHC_SSTO_CTG1:30190775 - 30190775(1)	intron_variant; non_coding_transcript_variant
rs885912	chrCHR_HSCHR6_MHC_SSTO_CTG1:30197207 - 30197207(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs2523713	chrCHR_HSCHR6_MHC_SSTO_CTG1:30195904 - 30195904(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs2428504	chrCHR_HSCHR6_MHC_SSTO_CTG1:30173964 - 30173964(1)	downstream_gene_variant
rs2523716	chrCHR_HSCHR6_MHC_SSTO_CTG1:30193098 - 30193098(1)	intron_variant; non_coding_transcript_variant
rs1117490	chrCHR_HSCHR6_MHC_SSTO_CTG1:30193083 - 30193083(1)	intron_variant; non_coding_transcript_variant
rs971570	chrCHR_HSCHR6_MHC_SSTO_CTG1:30195087 - 30195087(1)	5_prime_UTR_variant; intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant
rs2844776	chrCHR_HSCHR6_MHC_SSTO_CTG1:30194401 - 30194401(1)	intron_variant; non_coding_transcript_variant
rs2072106	chrCHR_HSCHR6_MHC_SSTO_CTG1:30189594 - 30189594(1)	5_prime_UTR_variant; intron_variant; non_coding_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 6	chr6:0-170805979	3 (0/3/0)
6p22	chr6:15200000-30500000	1 (0/1/0)
6p23-p21.1	chr6:13400000-46200000	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 2)

Reference	Description	Result Category
22614287	We also provide strong evidence for overlap in genetic risk between schizophrenia and bipolar disorder.	Positive
24888570	The associated SNP in this gene showed significant association with SZ.	Positive

Overlap with SZ from candidate gene intersection analysis (count: 0)

Gene relationship with MDD

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Region: chr6:30184455..30213427 View in gBrowse