Gene Report

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Basic Info

Approved Symbol	LRRIQ3
Previous Symbol	LRRC44
Symbol Alias	MGC22773
Approved Name	leucine-rich repeats and IQ motif containing 3
Previous Name	leucine rich repeat containing 44
Location	1p31.1
Position	chr1:74026015-74198187, -1
External Links	HGNC: 28318 Entrez Gene: 127255 Ensembl: ENSG00000162620 UCSC: uc001dfy.4
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Curtis, D.,2011	SNP: rs11210359	There is a trend of this gene for significant association.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005515	protein binding	molecular function	IPI[25416956]	563

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs11210359	chr1:73873484 - 73873484(1)		1(0/0/1)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
1p32.1-q31.1	chr1:58500000-190800000	1 (0/1/0)
1p31.1-p22.1	chr1:69300000-94300000	1 (0/1/0)
Chr 1	chr1:0-248956422	2 (0/2/0)
1p31.1	chr1:69300000-84400000	0

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
21057379	There is a trend of this gene for significant association.	Trend

Gene relationship with MDD

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Region: chr1:74026015..74198187 View in gBrowse