BDgene

SNP Report

Basic Info
Name rs1935058 dbSNP Ensembl
Location chr13:105459001 - 105459001(1)
Variant Alleles C/T
Ancestral Allele C
Minor Allele C
Minor Allele Frequence 0.4998
Functional Annotation downstream_gene_variant; upstream_gene_variant.
Consequence to Transcript downstream_gene_variant(ENST00000448407); upstream_gene_variant(ENST00000610818, ENST00000613021)
No. of Studies 7 (Positive: 3; Negative: 4; Trend: 0)
Source Literature
Overlap with SZ? YES
Overlap with MDD? YES

SNP related studies (count: 7)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Hattori, E.,2003 C/T C Association analysis: for CNG pedigrees, TDT P-value = 0.000...... Association analysis: for CNG pedigrees, TDT P-value = 0.00077, Transmission Ratio=1; for NIMH pedigrees, TDT P-value = 0.055, Transmission Ratio=0.63 More... Significant association was found in BD. Significant association was found in BD. Positive
Maheshwari, M.,2009 C/T TDT: Raw TDT P-value = 0.171, Adaptive permutation corrected...... TDT: Raw TDT P-value = 0.171, Adaptive permutation corrected P-value = 1 STEPC: sib_tdt P-value = 0.0009, TG P-value = 0.055 More... No significant allelic association with BP was found, but as...... No significant allelic association with BP was found, but association underlies the previously observed linkage signals in the CNGsample set was found. More... Positive
Chen, Y. S.,2004 T/C Single-marker association results: Likelihood ratio statisti...... Single-marker association results: Likelihood ratio statistic is 0.0515, P-value > 0.05, OR=0.96 More... No significant association was observed in BD. No significant association was observed in BD. Negative
Detera-Wadleigh, S. D., 2006 C/T Fisher P-value = 0.0015 for all, P-value = 0.0153 for BP Onl...... Fisher P-value = 0.0015 for all, P-value = 0.0153 for BP Only More... When results are combined across studies and phenotypes, thi...... When results are combined across studies and phenotypes, this marker showed significant combined p value. Only three studies have been published in bipolar-disorder samples, but significant (p<0.05) combined results are seen for three markers spanning more than 74 kb. More... Positive
Gawlik, M.,2010 C/T Armitage's trend test: P-value = 0.29 Armitage's trend test: P-value = 0.29 No significant association was observed in BD. No significant association was observed in BD. Negative
Shi, J., 2008 (a) C OR (95% CI)=1.26 (0.78-2.04) , Z test P-value = 0.34 for Eu...... OR (95% CI)=1.26 (0.78-2.04) , Z test P-value = 0.34 for European samples. More... No single maker showed evidence of overall association with ...... No single maker showed evidence of overall association with BP. More... Negative
Williams, N. M., 2006 allelic P-value = 0.3, Gene-wide test P-value = 0.045 in Bip...... allelic P-value = 0.3, Gene-wide test P-value = 0.045 in Bipolar I Disorder More... We observed significant evidence for whole-gene association ...... We observed significant evidence for whole-gene association (P=.04). More... Negative

SNP related genes (count: 2)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
DAOA-AS1 DAOA antisense RNA 1 13q33.2 Mapped by Literature SNP
DAOA D-amino acid oxidase activator 13q33.2 21(13/7/1)

SNPs in LD with rs1935058 (count: 0) View in gBrowse (chr13:105459001..105459001 )

Overlap with SZ from cross-disorder studies (count: 2)
Reference Statistical Result Description Result Category
Williams, N. M., 2006 allelic P-value = 0.52 in Schizophrenia We found no evidence for allelic or genotypic association with any of the polymorphisms studied for schizophrenia. We observed nominally significant evidence (P=.01-.047) for allelic association with 3 of the polymorphisms for bipolar disorder and significant evidence for whole-gene association (P=.04). Negative
Detera-Wadleigh, S. D., 2006 Fisher P-value = 0.0015 for all, P-value = 0.4416 for SCZ Only When results are combined across studies and phenotypes, this marker showed significant combined p value. Combined results in schizophrenia are significant for several markers. Positive

Overlap with MDD from cross-disorder studies (count: 1)
Reference Statistical Result Description Result Category
Gawlik, M.,2010 Armitage's trend test:P-value = 0.3 No significant association was observed. Negative