SNP Report

Basic Info

Name	rs17025005 dbSNP Ensembl
Location	chr2:100937152 - 100937152(1)
Variant Alleles	C/T
Ancestral Allele	T
Minor Allele	T
Minor Allele Frequence	0.159944
Functional Annotation	intron_variant; non_coding_transcript_variant.
Consequence to Transcript	intron_variant(ENST00000335681, ENST00000427413, ENST00000448812, ENST00000451740, ENST00000486017, ENST00000492373); non_coding_transcript_variant(ENST00000486017, ENST00000492373)
No. of Studies	2 (Positive: 1; Negative: 1; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	YES

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Mansour, H. A.,2009	A/G		Single SNP-based analyses: Trends test P-value = 0.009 in BP...... Single SNP-based analyses: Trends test P-value = 0.009 in BPI More...	Significant association was observed Significant association was observed	Positive
Soria, V.,2010			X²-tests: allele P-value > 0.05, genotype P-value...... X²-tests: allele P-value > 0.05, genotype P-value > 0.05 in all model More...	No significant association was observed in BD. No significant association was observed in BD.	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
NPAS2	neuronal PAS domain protein 2	2q11.2	5(3/2/0)

SNPs in LD with rs17025005 (count: 0) View in gBrowse (chr2:100937152..100937152 )

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Mansour, H. A.,2009	Single SNP-based analyses:Trends test P-value = 0.085 in SZ	No significant association was observed	Negative

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Soria, V.,2010	X²-tests:allele P-value = 0.092, Model Dominant, genotype P-value = 0.039, OR(95%CI)=0.72 (0.53-0.98)	Significant association was found.	Positive