SNP Report

Basic Info

Name	rs3766512 dbSNP Ensembl
Location	chr1:147625834 - 147625834(1)
Variant Alleles	T/C
Ancestral Allele	T
Minor Allele	C
Minor Allele Frequence	0.180911
Functional Annotation	3_prime_UTR_variant; downstream_gene_variant.
Consequence to Transcript	3_prime_UTR_variant(ENST00000234739); downstream_gene_variant(ENST00000609196)
No. of Studies	1 (Positive: 0; Negative: 1; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	YES

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Li, J.,2011(b)	C/T		Third-Stage Sample: for BPD, allele association P-value = 0....... Third-Stage Sample: for BPD, allele association P-value = 0.19, OR(95%CI)=1.08(0.96-1.22) More...	No significant association was observed. No significant association was observed.	Negative

SNP related genes (count: 2)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
ACP6	acid phosphatase 6, lysophosphatidic	1q21	1(1/0/0)
BCL9	B-cell CLL/lymphoma 9	1q21	1(1/0/0)

SNPs in LD with rs3766512 (count: 24) View in gBrowse (chr1:147624993..147665867 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 24)

rs_ID	Functional Annotation	r²[population]
rs11240098	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant	0.886[CHB]
rs1578723	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant	0.896[CHB]; 0.809[CHD]
rs2297961	3_prime_UTR_variant; downstream_gene_variant	0.898[CHB]; 0.951[CHD]
rs12045199	3_prime_UTR_variant; downstream_gene_variant; intron_variant	0.889[CHB]; 0.827[JPT]
rs11240102	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant	0.882[CHB]
rs7539714	downstream_gene_variant; intron_variant	0.849[CHB]
rs3820126	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	0.843[CHB]
rs867270	3_prime_UTR_variant; downstream_gene_variant	0.844[CHB]; 0.951[CHD]
rs3766507	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	0.844[CHB]
rs6681587	intron_variant	0.933[CHB]
rs3818888	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant	0.896[CHB]
rs10157759	intron_variant	1.0[CHB]
rs6663082	intron_variant	1.0[CHB]
rs6677434	intron_variant	1.0[CHB]
rs3766510	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	0.896[CHB]; 0.828[CHD]
rs6667707	downstream_gene_variant	0.849[CHB]
rs1417279	intron_variant	1.0[CHB]; 0.953[CHD]
rs870434	downstream_gene_variant; intron_variant	1.0[CHB]; 0.953[CHD]
rs3820127	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant	0.896[CHB]; 0.809[CHD]
rs3766506	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	0.843[CHB]
rs10793694	downstream_gene_variant; intron_variant	1.0[CHB]
rs12045709	downstream_gene_variant; intron_variant	1.0[CHB]
rs11240100	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant	0.896[CHB]; 0.809[CHD]
rs12025871	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant	0.896[CHB]; 0.809[CHD]

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Li, J.,2011(b)	Third-Stage Sample:for SZ, allele association P-value = 0.23, OR(95%CI)=1.08(0.95-1.22);Combined Third-Stage Sample, allele association P-value = 0.01, OR(98%CI)=1.08(1.02-1.15)	Significant association was observed in SZ.	Positive

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Li, J.,2011(b)	Third-Stage Sample:for MDD, allele association P-value = 0.13, OR(95%CI)=1.10(0.97-1.24)	No significant association was observed.	Negative