BDgene

SNP Report

Basic Info
Name rs3916966 dbSNP Ensembl
Location chr13:105458546 - 105458546(1)
Variant Alleles C/A
Ancestral Allele A
Minor Allele C
Minor Allele Frequence 0.417732
Functional Annotation downstream_gene_variant; upstream_gene_variant.
Consequence to Transcript downstream_gene_variant(ENST00000448407); upstream_gene_variant(ENST00000610818, ENST00000613021)
No. of Studies 4 (Positive: 1; Negative: 3; Trend: 0)
Source Literature
Overlap with SZ? YES
Overlap with MDD? YES

SNP related studies (count: 4)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Gawlik, M.,2010 A/C Armitage's trend test: P-value = 0.2 Armitage's trend test: P-value = 0.2 No significant association was observed in BD. No significant association was observed in BD. Negative
Detera-Wadleigh, S. D., 2006 A/C Fisher P-value = 0.0413 for all Fisher P-value = 0.0413 for all When results are combined across studies and phenotypes, thi...... When results are combined across studies and phenotypes, this marker showed significant combined p value More... Positive
Prata, D., 2008 data not shown data not shown Analysis of each SNP individually showed no significant asso...... Analysis of each SNP individually showed no significant association. More... Negative
Maheshwari, M.,2009 G/T TDT: Raw TDT P-value = 0.162, Adaptive permutation corrected...... TDT: Raw TDT P-value = 0.162, Adaptive permutation corrected P-value = 0.875 More... No significant allelic association with BP was found No significant allelic association with BP was found Negative

SNP related genes (count: 2)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
DAOA-AS1 DAOA antisense RNA 1 13q33.2 Mapped by Literature SNP
DAOA D-amino acid oxidase activator 13q33.2 21(13/7/1)

SNPs in LD with rs3916966 (count: 12) View in gBrowse (chr13:105448044..105464458 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 12)


Overlap with SZ from cross-disorder studies (count: 1)
Reference Statistical Result Description Result Category
Detera-Wadleigh, S. D., 2006 Fisher P-value = 0.0413 for all, P-value = 0.0683 for SCZ Only When results are combined across studies and phenotypes, this marker showed significant combined p value. Combined results in schizophrenia are significant for several markers. Positive

Overlap with MDD from cross-disorder studies (count: 1)
Reference Statistical Result Description Result Category
Gawlik, M.,2010 Armitage's trend test:P-value = 0.54 No significant association was observed. Negative