SNP Report

Basic Info

Name	rs3916966 dbSNP Ensembl
Location	chr13:105458546 - 105458546(1)
Variant Alleles	C/A
Ancestral Allele	A
Minor Allele	C
Minor Allele Frequence	0.417732
Functional Annotation	downstream_gene_variant; upstream_gene_variant.
Consequence to Transcript	downstream_gene_variant(ENST00000448407); upstream_gene_variant(ENST00000610818, ENST00000613021)
No. of Studies	4 (Positive: 1; Negative: 3; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	YES

SNP related studies (count: 4)

Reference	Allele Change	Statistical Values	Author Comments	Result Category
Gawlik, M.,2010	A/C	Armitage's trend test: P-value = 0.2 Armitage's trend test: P-value = 0.2	No significant association was observed in BD. No significant association was observed in BD.	Negative
Detera-Wadleigh, S. D., 2006	A/C	Fisher P-value = 0.0413 for all Fisher P-value = 0.0413 for all	When results are combined across studies and phenotypes, thi...... When results are combined across studies and phenotypes, this marker showed significant combined p value More...	Positive
Prata, D., 2008		data not shown data not shown	Analysis of each SNP individually showed no significant asso...... Analysis of each SNP individually showed no significant association. More...	Negative
Maheshwari, M.,2009	G/T	TDT: Raw TDT P-value = 0.162, Adaptive permutation corrected...... TDT: Raw TDT P-value = 0.162, Adaptive permutation corrected P-value = 0.875 More...	No significant allelic association with BP was found No significant allelic association with BP was found	Negative

SNP related genes (count: 2)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
DAOA-AS1	DAOA antisense RNA 1	13q33.2	Mapped by Literature SNP
DAOA	D-amino acid oxidase activator	13q33.2	21(13/7/1)

SNPs in LD with rs3916966 (count: 12) View in gBrowse (chr13:105448044..105464458 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Functional Annotation	r²[population]
rs9519675	downstream_gene_variant; upstream_gene_variant	0.812[CEU]
rs4581580		0.959[CEU]; 1.0[TSI]
rs9558553		0.959[CEU]; 0.953[TSI]
rs7331194		0.916[CEU]
rs1126113		0.959[CEU]; 0.953[TSI]
rs1341403	downstream_gene_variant; intron_variant; non_coding_transcript_variant; upstream_gene_variant	0.959[CEU]; 0.976[TSI]
rs4772687	downstream_gene_variant; intron_variant; non_coding_transcript_variant; upstream_gene_variant	0.811[CEU]
rs9519679	downstream_gene_variant; upstream_gene_variant	0.815[CEU]; 0.811[TSI]
rs6491959		0.958[CEU]
rs6491960		0.958[CEU]
rs9555168		0.959[CEU]
rs1126115		0.959[CEU]

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Detera-Wadleigh, S. D., 2006	Fisher P-value = 0.0413 for all, P-value = 0.0683 for SCZ Only	When results are combined across studies and phenotypes, this marker showed significant combined p value. Combined results in schizophrenia are significant for several markers.	Positive

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Gawlik, M.,2010	Armitage's trend test:P-value = 0.54	No significant association was observed.	Negative