BDgene

SNP Report

Basic Info
Name rs2919390 dbSNP Ensembl
Location chr8:32669436 - 32669436(1)
Variant Alleles A/C
Ancestral Allele C
Minor Allele A
Minor Allele Frequence 0.484425
Functional Annotation intron_variant; non_coding_transcript_variant.
Consequence to Transcript intron_variant(ENST00000287842, ENST00000356819, ENST00000405005, ENST00000518104, ENST00000518206, ENST00000519301, ENST00000520407, ENST00000520502, ENST00000521670, ENST00000522569, ENST00000523041, ENST00000523079, ENST00000523534, ENST00000631040); non_coding_transcript_variant(ENST00000522569)
No. of Studies 3 (Positive: 2; Negative: 1; Trend: 0)
Source Literature
Overlap with SZ? YES
Overlap with MDD? NO

SNP related studies (count: 3)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Thomson, P. A., 2007 Individual P-value = 0.0793 for BP, Individual P-value = 0.0...... Individual P-value = 0.0793 for BP, Individual P-value = 0.0105 for SCZ and BP More... This marker is nominally significant in the combined sample This marker is nominally significant in the combined sample Positive
Yosifova, A.,2009 A/C Allelic association: P-value = 0.24 Allelic association: P-value = 0.24 No significant association was observed No significant association was observed Negative
Walker, R. M.,2010 X2 test: P-value = 0.08 for Scottish 1, P-value =...... X2 test: P-value = 0.08 for Scottish 1, P-value = 0.073 for German More... Significant association was found in BD. Significant association was found in BD. Positive

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
NRG1 neuregulin 1 8p12 15(10/5/0)

SNPs in LD with rs2919390 (count: 0) View in gBrowse (chr8:32669436..32669436 )

Overlap with SZ from cross-disorder studies (count: 2)
Reference Statistical Result Description Result Category
Walker, R. M.,2010 X2 test:P-value = 0.01 for Scottish 1, P-value = 0.92 for German Significant association was found. Positive
Thomson, P. A., 2007 Individual P-value = 0.0096 for SCZ , Individual P-value = 0.0105 for SCZ and BP This marker is nominally significant in the combined sample Positive

Overlap with MDD from cross-disorder studies (count: 0)