SNP Report

Basic Info

Name	rs2919390 dbSNP Ensembl
Location	chr8:32669436 - 32669436(1)
Variant Alleles	A/C
Ancestral Allele	C
Minor Allele	A
Minor Allele Frequence	0.484425
Functional Annotation	intron_variant; non_coding_transcript_variant.
Consequence to Transcript	intron_variant(ENST00000287842, ENST00000356819, ENST00000405005, ENST00000518104, ENST00000518206, ENST00000519301, ENST00000520407, ENST00000520502, ENST00000521670, ENST00000522569, ENST00000523041, ENST00000523079, ENST00000523534, ENST00000631040); non_coding_transcript_variant(ENST00000522569)
No. of Studies	3 (Positive: 2; Negative: 1; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	NO

SNP related studies (count: 3)

Reference	Allele Change	Statistical Values	Author Comments	Result Category
Thomson, P. A., 2007		Individual P-value = 0.0793 for BP, Individual P-value = 0.0...... Individual P-value = 0.0793 for BP, Individual P-value = 0.0105 for SCZ and BP More...	This marker is nominally significant in the combined sample This marker is nominally significant in the combined sample	Positive
Yosifova, A.,2009	A/C	Allelic association: P-value = 0.24 Allelic association: P-value = 0.24	No significant association was observed No significant association was observed	Negative
Walker, R. M.,2010		X² test: P-value = 0.08 for Scottish 1, P-value =...... X² test: P-value = 0.08 for Scottish 1, P-value = 0.073 for German More...	Significant association was found in BD. Significant association was found in BD.	Positive

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
NRG1	neuregulin 1	8p12	15(10/5/0)

SNPs in LD with rs2919390 (count: 0) View in gBrowse (chr8:32669436..32669436 )

Overlap with SZ from cross-disorder studies (count: 2)

Reference	Statistical Result	Description	Result Category
Walker, R. M.,2010	X² test:P-value = 0.01 for Scottish 1, P-value = 0.92 for German	Significant association was found.	Positive
Thomson, P. A., 2007	Individual P-value = 0.0096 for SCZ , Individual P-value = 0.0105 for SCZ and BP	This marker is nominally significant in the combined sample	Positive

Overlap with MDD from cross-disorder studies (count: 0)