Gene Report

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Basic Info

Approved Symbol	SH3RF3
Previous Symbol	SH3MD4
Symbol Alias	FLJ00204, POSH2
Approved Name	SH3 domain containing ring finger 3
Previous Name	SH3 multiple domains 4
Location	2q13
Position	chr2:109129348-109504632, 1
External Links	HGNC: 24699 Entrez Gene: 344558 Ensembl: ENSG00000172985 UCSC: uc010ywt.1
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Gonzalez, S., 2014	SNP: rs1864474	It showed nominal evidence for association with BD.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 2)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0008270	zinc ion binding	molecular function	IEA	77
GO:0005515	protein binding	molecular function	IPI[16374509]	563

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
SH3RF3	ADAM15	NO	in vitro	16374509
SH3RF3	PAK2	NO	in vitro	16374509

Related other genetic factors

Gene related SNPs (count: 2)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs11692886	chr2:109516602 - 109516602(1)		1(1/0/0)
rs1864474	chr2:109243063 - 109243063(1)	intron_variant	1(0/0/1)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
2q12.3-q22.1	chr2:106700000-141500000	1 (0/1/0)
2p13	chr2:108700000-112200000	2 (2/0/0)
Chr 2	chr2:0-242193529	3 (0/3/0)
2p11-q14	chr2:83100000-129100000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr2:109129348..109504632 View in gBrowse