Gene Report

Basic Info
Approved Symbol TIMELESS
Symbol Alias hTIM, TIM, TIM1
Approved Name timeless circadian clock
Previous Name timeless (Drosophila) homolog, "timeless homolog (Drosophila)"
Name Alias Tof1 homolog (S. cerevisiae), "timeless circadian clock 1"
Location 12q13.3
Position chr12:56416373-56449403, -1
External Links HGNC: 11813
Entrez Gene: 8914
Ensembl: ENSG00000111602
UCSC: uc001slf.2
No. of Studies 3 (Positive: 0; Negative: 3; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 3)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Byrne, E. M., 2014 P-value=0.27. It is notable that there are no SNPs in or near the TIMELESS gene that show evidence of association with risk to BPD, and similarly, the CLOCK gene harbors only one SNP that just reaches the nominal significance threshold (P=0.042), indicating that these genes are not strong candidates for influencing BPD risk in the population. Negative Comment on Study
Mansour, H. A.,2009 Gene-based tests:X<sup>2</sup>=3.072, P-value = 0.271 in recessive model, X<sup>2</sup>=0.332, P-value = 0.968 in additive model, X<sup>2</sup>=0.251, P-value = 0.993 in dominant model in BPI. No significant association was observed using neither single SNP-based analyses nor gene-based tests in BPI. Negative Comment on Study
Mansour, H. A., 2006 SNP: rs2279665, rs2291738, rs2291739, rs774026
Haplotype: rs2279665 - rs774026 - rs2291738 - rs2291739()
No significant association was detected in any sample using any test. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 22)

GO terms by PBA (count: 1)

GO terms by database search (count: 21)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 5)

Related other genetic factors
Gene related SNPs (count: 26)

Literature-origin SNPs (count: 5)

LD-proxies (count: 21)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 3)

Overlap with SZ from candidate gene intersection analysis (count: 2)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Overlap with MDD from candidate gene intersection analysis (count: 0)

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Region: chr12:56416373..56449403 View in gBrowse
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