Gene Report

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Basic Info

Approved Symbol	PPP2R2D
Symbol Alias	MDS026
Approved Name	protein phosphatase 2, regulatory subunit B, delta
Previous Name	protein phosphatase 2, regulatory subunit B, delta isoform
Name Alias	PP2A subunit B isoform delta
Location	10q26.3
Position	chr10:131900644-131959834, 1
External Links	HGNC: 23732 Entrez Gene: 55844 Ensembl: ENSG00000175470 UCSC: uc031wxk.1
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	YES
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Huang, J.,2010	SNP: rs7071307	Suggestive association was found in BD-II.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 9)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007165	signal transduction	biological process	IEA	136
GO:0000278	mitotic cell cycle	biological process	TAS	33
GO:0007067	mitotic nuclear division	biological process	ISS	15
GO:0005737	cytoplasm	cellular component	IEA	322
GO:0010458	exit from mitosis	biological process	ISS	1
GO:0008601	protein phosphatase type 2A regulator activity	molecular function	ISS	5
GO:0000159	protein phosphatase type 2A complex	cellular component	ISS	5
GO:0051301	cell division	biological process	IEA	20
GO:0050790	regulation of catalytic activity	biological process	IEA; ISS	11

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
PPP2R2D	SUPT5H	NO	yeast 2-hybrid	16169070

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs7071307	chr10:131557326 - 131557326(1)		1(0/0/1)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 10	chr10:0-133797422	3 (0/2/1)
10q25-q26	chr10:104000000-133797422	2 (0/0/2)
10q26.3	chr10:128800000-133797422	1 (0/0/1)
10q26	chr10:117300000-133797422	3 (0/1/2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
20713499	No significant association of this gene was observed in SZ.	Negative

Gene relationship with MDD

Reference	Description	Category in MDD
20713499	No significant association was observed in MDD.	Negative

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Region: chr10:131900644..131959834 View in gBrowse