Gene Report

Basic Info
Approved Symbol SP4
Symbol Alias SPR-1, HF1B, MGC130008, MGC130009
Approved Name Sp4 transcription factor
Location 7p15
Position chr7:21428034-21514822, 1
External Links HGNC: 11209
Entrez Gene: 6671
Ensembl: ENSG00000105866
UCSC: uc003sva.3
No. of Studies 1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Zhou, X.,2009 SNP: rs1018954, rs10245440, rs10261327, rs10276352, rs11974306, rs12668354, rs12673091, rs2282888, rs3735440, rs40245
Haplotype: rs12668354 - rs12673091 - rs1018954 - rs3735440(A-A-A-T), rs12668354 - rs12673091 - rs1018954 - rs3735440(A-G-T-T), rs12668354 - rs12673091 - rs1018954 - rs3735440(C-A-T-C), rs12668354 - rs12673091 - rs1018954 - rs3735440 - rs11974306(A-A-A-C-T), rs12668354 - rs12673091 - rs1018954 - rs3735440 - rs11974306(A-A-A-T-A), rs12668354 - rs12673091 - rs1018954 - rs3735440 - rs11974306(A-A-A-T-T), rs12668354 - rs12673091 - rs1018954 - rs3735440 - rs11974306(A-G-A-T-A), rs12668354 - rs12673091 - rs1018954 - rs3735440 - rs11974306(A-G-T-T-A), rs12668354 - rs12673091 - rs1018954 - rs3735440 - rs11974306(A-G-T-T-T), rs12668354 - rs12673091 - rs1018954 - rs3735440 - rs11974306(C-A-T-C-T)
Our human genetic association studies provide direct evidence for the human SP4 gene as a susceptibility gene for both bipolar disorder and schizophrenia. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 12)

GO terms by PBA (count: 1)

GO terms by database search (count: 11)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Related other genetic factors
Gene related SNPs (count: 51)

Literature-origin SNPs (count: 10)

LD-proxies (count: 41)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Gene relationship with MDD

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Region: chr7:21428034..21514822 View in gBrowse
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