SNP Report

Basic Info

Name	rs2303377 dbSNP Ensembl
Location	chr11:113240779 - 113240779(1)
Variant Alleles	T/C
Ancestral Allele	T
Minor Allele	C
Minor Allele Frequence	0.413938
Functional Annotation	intron_variant; NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; splice_region_variant.
Consequence to Transcript	intron_variant(ENST00000316851, ENST00000401611, ENST00000525355, ENST00000526322, ENST00000528590, ENST00000530543, ENST00000531044, ENST00000531817, ENST00000533073, ENST00000611284, ENST00000615112, ENST00000615285, ENST00000618266, ENST00000619839, ENST00000620046, ENST00000621128, ENST00000621518, ENST00000621850); NMD_transcript_variant(ENST00000531817); non_coding_transcript_exon_variant(ENST00000525691); non_coding_transcript_variant(ENST00000525355, ENST00000525691, ENST00000611284); splice_region_variant(ENST00000526322, ENST00000528590, ENST00000531817, ENST00000621518, ENST00000621850)
No. of Studies	1 (Positive: 1; Negative: 0; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	NO

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Atz, M. E., 2007	T/C		Fisher's exact test, allelic P-value = 0.402, OR=0.82 in BD;...... Fisher's exact test, allelic P-value = 0.402, OR=0.82 in BD; Fisher's exact test, allelic P-value = 0.264 in BD&SZ; Heterozygous genotypic association (A/A-C/A): chi-square P-value = 0.02, X²=5.33, OR(95%CI)=4.05 (1.16-14.12); Homozygous genotypic association (C/C-A/A): chi-square P-value = 0.103, X²=2.65, OR(95%CI)=2.97 (0.78-11.30); Allele positivity [(C/C+C/A)-A/A]: chi-square P-value = 0.028, X²=4.81, OR(95%CI)=3.66 (1.08-11.30) in BD More...	The allelic frequencies for bipolar and control cases were n...... The allelic frequencies for bipolar and control cases were not different, but it showed heterozygote association with BPD and allele positivity. More...	Positive

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
NCAM1	neural cell adhesion molecule 1	11q23.2	3(2/1/0)

SNPs in LD with rs2303377 (count: 0) View in gBrowse (chr11:113240779..113240779 )

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Atz, M. E., 2007	Fisher's exact test, allelic P-value = 0.24 in SZ; Fisher's exact test, allelic P-value = 0.264 in BD&SZ	SNP b was not associated with SZ.	Negative

Overlap with MDD from cross-disorder studies (count: 0)