SNP Report

Basic Info

Name	rs10276352 dbSNP Ensembl
Location	chr7:21481615 - 21481615(1)
Variant Alleles	G/A
Ancestral Allele	G
Minor Allele	A
Minor Allele Frequence	0.425919
Functional Annotation	downstream_gene_variant; intron_variant; NMD_transcript_variant.
Consequence to Transcript	downstream_gene_variant(ENST00000432066); intron_variant(ENST00000222584, ENST00000448246); NMD_transcript_variant(ENST00000448246)
No. of Studies	1 (Positive: 0; Negative: 1; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	NO

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Zhou, X.,2009	A/G		Allelic association: Caucasian Families for Bipolar Disorder...... Allelic association: Caucasian Families for Bipolar Disorder: TDT: Risk allele is G, MAF=0.44P-value = 0.102; Chinese Case-Controls for Bipolar Disorder: Risk allele is G, MAF=0.28, P-value = 0.095 More...	No significant association was observed. No significant association was observed.	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
SP4	Sp4 transcription factor	7p15	1(1/0/0)

SNPs in LD with rs10276352 (count: 7) View in gBrowse (chr7:21436570..21481615 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Functional Annotation	r²[population]
rs2237305	downstream_gene_variant; intron_variant; NMD_transcript_variant	0.97[CHD]
rs2107448	intron_variant; NMD_transcript_variant	0.887[CEU]; 0.909[TSI]; 0.863[CHB]; 0.941[CHD]
rs1978154	intron_variant; NMD_transcript_variant	0.887[CEU]; 0.887[TSI]; 0.933[CHB]; 0.941[CHD]; 1.0[JPT]
rs2282889	intron_variant; NMD_transcript_variant	0.882[CEU]; 0.933[CHB]; 0.939[JPT]
rs10239423	intron_variant; NMD_transcript_variant	0.925[CHB]; 0.878[JPT]
rs2282893	intron_variant; NMD_transcript_variant	0.911[CHD]
rs2282894	intron_variant; NMD_transcript_variant	0.961[CEU]; 0.863[CHB]

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Zhou, X.,2009	Allelic association:Chinese Trios for Schizophrenia:TDT:Risk allele is G, MAF=0.281, P-value = 0.526	No significant association was observed	Negative

Overlap with MDD from cross-disorder studies (count: 0)