SNP Report

Basic Info

Name	rs2269577 dbSNP Ensembl
Location	chr22:28800769 - 28800769(1)
Variant Alleles	G/C
Ancestral Allele	C
Minor Allele	G
Minor Allele Frequence	0.4998
Functional Annotation	intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant.
Consequence to Transcript	intron_variant(ENST00000418292, ENST00000458080); non_coding_transcript_exon_variant(ENST00000585003); non_coding_transcript_variant(ENST00000418292, ENST00000458080, ENST00000585003); upstream_gene_variant(ENST00000216037, ENST00000344347, ENST00000403532, ENST00000405219, ENST00000451486, ENST00000482720, ENST00000484256, ENST00000611155)
No. of Studies	1 (Positive: 1; Negative: 0; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	NO

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Cheng, D., 2014	C/G		GG vs. CC: Total: OR=1.13, 95%CI= 0.97-1.31, P-value=0.13. I...... GG vs. CC: Total: OR=1.13, 95%CI= 0.97-1.31, P-value=0.13. Illness types (Bipolar disorder): OR=1.10, 95%CI=0.87-1.38. Ethnicity: Asia: OR=1.31, 95%CI=0.71-2.43; Europe: OR=0.98, 95%CI=0.80-1.20. Asian Illness (Bipolar disorder): OR=1.23, 95%CI=0.29-5.22. European Illness (Bipolar disorder): OR=0.91, 95%CI=0.69-1.19. CG vs. CC: Total: OR=1.04, 95%CI=0.92-1.17, P-value=0.54. Illness types (Bipolar disorder): OR=0.99, 95%CI=0.85-1.15. Ethnicity: Asia: OR=1.27, 95%CI=1.00-1.61, P-value=0.05; Europe: OR=0.97, 95%CI=0.84-1.11, P-value=0.65. Asian Illness (Bipolar disorder): OR=1.81, 95%CI=1.15-2.86, P-value=0.01. European Illness (Bipolar disorder): OR=0.91, 95%CI=0.78-1.07. GG+CG vs. CC: Total: OR=1.04, 95%CI=0.93-1.17, P-value=0.48. Illness types (Bipolar disorder): OR=0.99, 95%CI=0.86-1.14. Ethnicity: Asia: OR=1.32, 95%CI=1.05-1.65, P-value=0.02; Europe: OR=0.96, 95%CI=0.84-1.09, P-value=0.52. Asian Illness (Bipolar disorder): OR=1.34, 95%CI=0.35-5.17. European Illness (Bipolar disorder): OR=0.91, 95%CI=0.78-1.06. GG vs. CG+CC: Total: OR=1.01, 95%CI=0.91-1.12, P-value=0.84. Illness types (Bipolar disorder): OR=1.01, 95%CI=0.85-1.21. Ethnicity: Asia: OR=1.10, 95%CI=0.96-1.27; Europe: OR=0.92, 95%CI=0.80-1.07. Asian Illness (Bipolar disorder): OR=1.08, 95%CI=0.84-1.38. European Illness (Bipolar disorder): OR=0.95, 95%CI=0.73-1.23. More...	The XBP1-116C/G polymorphism is associated with an increased...... The XBP1-116C/G polymorphism is associated with an increased risk of bipolar disorder in Asian population. More...	Positive

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
XBP1	X-box binding protein 1	22q12.1	3(2/1/0)

SNPs in LD with rs2269577 (count: 0) View in gBrowse (chr22:28800769..28800769 )

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Cheng, D., 2014	GG vs. CC: Illness types (Schizophrenia): OR=1.15, 95%CI=0.93-1.41. Asian Illness (Schizophrenia): OR=1.24, 95%CI=0.66-2.33. European Illness (Schizophrenia): OR=1.07, 95%CI=0.79-1.45. CG vs. CC: Illness types (Schizophrenia): OR=1.14, 95%CI=0.93-1.40. Asian Illness (Schizophrenia): OR=1.13, 95%CI=0.63-2.04. European Illness (Schizophrenia): OR=1.19, 95%CI=0.88-1.61. GG+CG vs. CC: Illness types (Schizophrenia): OR=1.15, 95%CI=0.94-1.40. Asian Illness (Schizophrenia): OR=1.18, 95%CI=0.66-2.14. European Illness (Schizophrenia): OR=1.13, 95%CI=0.85-1.52. GG vs. CG+CC: Illness types (Schizophrenia): OR=1.01, 95%CI=0.89-1.14. Asian Illness (Schizophrenia): OR=1.11, 95%CI=0.94-1.32. European Illness (Schizophrenia): OR=0.91, 95%CI=0.77-1.08.	No significant association was found.	Negative

Overlap with MDD from cross-disorder studies (count: 0)