SNP Report

Basic Info

Name	rs6352 dbSNP Ensembl
Location	chr17:30203175 - 30203175(1)
Variant Alleles	T/G
Ancestral Allele	C
Minor Allele	G
Minor Allele Frequence	0.00858626
Functional Annotation	3_prime_UTR_variant; missense_variant; NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant. Polyphen Annotation: possibly damaging(ENST00000261707, ENST00000394821, ENST00000401766) SIFT Annotation: tolerated(ENST00000261707, ENST00000394821, ENST00000401766)
Consequence to Transcript	3_prime_UTR_variant(ENST00000579221); missense_variant(ENST00000261707, ENST00000394821, ENST00000401766); NMD_transcript_variant(ENST00000579221); non_coding_transcript_exon_variant(ENST00000578609); non_coding_transcript_variant(ENST00000578609); upstream_gene_variant(ENST00000581633)
No. of Studies	2 (Positive: 0; Negative: 2; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	NO

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Ikeda, M., 2006			allelic P-value = 0.489, genotypic P-value = 0.515, Power ca...... allelic P-value = 0.489, genotypic P-value = 0.515, Power calculation GRR=2.55 More...	No associations of 'tagging' marker with BP was found. No associations of 'tagging' marker with BP was found.	Negative
Sun, H. S., 2004	A/C		Fisher's exact test, allelic P-value = 0.11, genotypic P-val...... Fisher's exact test, allelic P-value = 0.11, genotypic P-value = 0.1 More...	No association can be obtained between any of the SLC6A4 gen...... No association can be obtained between any of the SLC6A4 gene polymorphisms and BPD. More...	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
SLC6A4	solute carrier family 6 (neurotransmitter transporter), member 4	17q11.2	44(18/26/0)

SNPs in LD with rs6352 (count: 0) View in gBrowse (chr17:30203175..30203175 )

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Ikeda, M., 2006	allelic P-value = 0.541, genotypic P-value = 0.911, Power calculation GRR=1.95	Asn605Lys showed weak association with SCZ, but the positive association can not be confirmed in an additional analysis	Negative

Overlap with MDD from cross-disorder studies (count: 0)