SNP Report

Basic Info

Name	rs5746826 dbSNP Ensembl
Location	chr22:19779528 - 19779528(1)
Variant Alleles	G/T
Ancestral Allele	T
Minor Allele	G
Minor Allele Frequence	0.407348
Functional Annotation	3_prime_UTR_variant; downstream_gene_variant; intron_variant.
Consequence to Transcript	3_prime_UTR_variant(ENST00000329705); downstream_gene_variant(ENST00000329517); intron_variant(ENST00000359500, ENST00000621939)
No. of Studies	1 (Positive: 0; Negative: 1; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	YES

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Funke, B. H., 2007	G/T	G	X²= 0.005, P-value = 0.943 for affective disorde...... X²= 0.005, P-value = 0.943 for affective disorder (BP + MDD) when compared with controls More...	None of the nine individual SNPs showed a positive associati...... None of the nine individual SNPs showed a positive association in the 'all affecteds' category. More...	Negative

SNP related genes (count: 2)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
TBX1	T-box 1	22q11.21	Mapped by Literature SNP
GNB1L	guanine nucleotide binding protein (G protein), beta polypeptide 1-like	22q11.2	1(1/0/0)

SNPs in LD with rs5746826 (count: 1) View in gBrowse (chr22:19779528..19784045 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Literature-origin SNPs with LD	Functional Annotation	r²[population]
rs2073762		3_prime_UTR_variant; downstream_gene_variant	0.883[CEU]

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Funke, B. H., 2007	X²= 1.676, P-value = 0.196 for schizophrenia when compared with controls.	None of the nine individual SNPs showed a positive association in the 'all affecteds' category.	Negative

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Funke, B. H., 2007	X²= 0.005, P-value = 0.943 for affective disorder (BP + MDD) when compared with controls	None of the nine individual SNPs showed a positive association in the 'all affecteds' category.	Negative