SNP Report

Basic Info

Name	rs6988339 dbSNP Ensembl
Location	chr8:32688398 - 32688398(1)
Variant Alleles	G/A
Ancestral Allele	A
Minor Allele	G
Minor Allele Frequence	0.345847
Functional Annotation	intron_variant; non_coding_transcript_variant.
Consequence to Transcript	intron_variant(ENST00000287842, ENST00000356819, ENST00000405005, ENST00000518104, ENST00000518206, ENST00000519301, ENST00000520407, ENST00000520502, ENST00000521670, ENST00000522569, ENST00000523041, ENST00000523079, ENST00000523534, ENST00000631040); non_coding_transcript_variant(ENST00000522569)
No. of Studies	3 (Positive: 2; Negative: 1; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	NO

SNP related studies (count: 3)

Reference	Allele Change	Statistical Values	Author Comments	Result Category
Thomson, P. A., 2007		Individual P-value = 0.0324 for BP, Individual P-value = 0.0...... Individual P-value = 0.0324 for BP, Individual P-value = 0.0058 for SCZ and BP More...	This marker is nominally significant in the combined sample This marker is nominally significant in the combined sample	Positive
Walker, R. M.,2010		X² test: P-value = 0.032 for Scottish 1, P-value ...... X² test: P-value = 0.032 for Scottish 1, P-value = 0.14 for Scottish 2, P-value = 0.19 for German, P-value = 0.55 for merged Scottish, P-value = 0.19 for merged all More...	Significant association was found in BD. Significant association was found in BD.	Positive
Yosifova, A.,2009	A/G	Allelic association: P-value = 0.23 Allelic association: P-value = 0.23	No significant association was observed No significant association was observed	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
NRG1	neuregulin 1	8p12	15(10/5/0)

SNPs in LD with rs6988339 (count: 2) View in gBrowse (chr8:32663803..32704925 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Literature-origin SNPs with LD	Functional Annotation	r²[population]
rs2439321		intron_variant; non_coding_transcript_variant	0.812[CEU]
rs4445183		intron_variant; non_coding_transcript_variant	0.851[CEU]; 0.86[TSI]

Overlap with SZ from cross-disorder studies (count: 2)

Reference	Statistical Result	Description	Result Category
Thomson, P. A., 2007	Individual P-value = 0.0103 for SCZ , Individual P-value = 0.0058 for SCZ and BP	This marker is nominally significant in the combined sample	Positive
Walker, R. M.,2010	X² test:P-value = 0.01 for Scottish 1, P-value = 0.55 for Scottish 2, P-value = 0.38 for German, P-value = 0.024 for merged Scottish, P-value = 0.22 for merged all	Significant association was found.	Positive

Overlap with MDD from cross-disorder studies (count: 0)