Meta-analysis Report

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Basic Info

Reference	Cheng, D., 2014 PMID: 25231123
Citation	Cheng, D., et al. (2014). "The -116C/G polymorphism in XBP1 gene is associated with psychiatric illness in Asian population: A meta-analysis." Am J Med Genet B Neuropsychiatr Genet.
Disease Type	Bipolar Disorder & Schizophrenia
Study Type	Candidate-gene association study

Detail Info

Samples	3512 cases and 4889 controls
Statistic Method	For each case-control study, we first examined whether the genotype frequencies in controls were consistent with HWE by X²-test. The strength of the association between XBP1-116C/G polymorphism and psychiatric illness was estimated by odds ratios (ORs) with corresponding 95% confidence intervals (CIs). Four different pooled ORs were performed for the homozygote comparison (G/G vs. C/C), heterozygote comparison (C/G vs. C/C), dominant (G/G+C/G vs. C/C) and recessive (G/G vs. C/G+C/C) genetic model comparison. The heterogeneity was assessed by the Chi-square test based Q-statistic, it was considered significant if P<0.10; and the degree of heterogeneity was further assessed with the I² statistics (I²=100%6(Q-df)/Q). If the I² is less than 75%, which indicates the heterogeneity is moderate, a fixed-effects model (the Mantel-Haenszel method) was applied to calculate the summary ORs. Otherwise, the random-effects model (the DerSimonian and Laird method) was used. Sensitivity analysis was performed by sequential omission of each individual study. Beggâ€™s funnel plot and Eggerâ€™s linear regression test were performed to evaluate the potential publication bias. All of the analyses were performed with RevMan 5.0.23 (Cochrane Library Software, Oxford, UK) and STATA11.0 software (STATA Corporation, College Station, Texas, USA).
Basic Result	Overall, no significant association was found between XBP1-116C/G polymorphism and the risk of psychiatric illness (C/G vs. C/C: OR=1.04, 95%CI=0.92-1.17, P-value=0.54). However, there was a significant association between this polymorphism and the psychiatric illness in Asian population (C/G vs. C/C: OR=1.27, 95%CI=1.00-1.61, P-value=0.05; G/GÃ¾C/G vs. C/C: OR=1.32, 95%CI=1.05-1.65, P-value=0.02). Furthermore, we found a significant association between XBP1-116C/G polymorphism and the risk of bipolar disorder in Asian population (C/G vs. C/C: OR=1.81, 95%CI=1.15-2.86, P-value=0.01). The XBP1-116C/G polymorphism is associated with an increased risk of bipolar disorder in Asian population.

Genetic factors reported by this study for BD

SNPs reported by this study for BD (count: 1)

SNP	Related Gene(s)	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs2269577	XBP1	C/G		GG vs. CC: Total: OR=1.13, 95%CI= 0.97-1.31, P-value=0.13. Illness types (Bipolar disorder): OR=1.10, 95%CI=0.87-1.38. Ethnicity: Asia: OR=1.31, 95%CI=0.71-2.43; Europe: OR=0.98, 95%CI=0.80-1.20. Asian Illness (Bipolar disorder): OR=1.23, 95%CI=0.29-5.22. European Illness (Bipolar disorder): OR=0.91, 95%CI=0.69-1.19. CG vs. CC: Total: OR=1.04, 95%CI=0.92-1.17, P-value=0.54. Illness types (Bipolar disorder): OR=0.99, 95%CI=0.85-1.15. Ethnicity: Asia: OR=1.27, 95%CI=1.00-1.61, P-value=0.05; Europe: OR=0.97, 95%CI=0.84-1.11, P-value=0.65. Asian Illness (Bipolar disorder): OR=1.81, 95%CI=1.15-2.86, P-value=0.01. European Illness (Bipolar disorder): OR=0.91, 95%CI=0.78-1.07. GG+CG vs. CC: Total: OR=1.04, 95%CI=0.93-1.17, P-value=0.48. Illness types (Bipolar disorder): OR=0.99, 95%CI=0.86-1.14. Ethnicity: Asia: OR=1.32, 95%CI=1.05-1.65, P-value=0.02; Europe: OR=0.96, 95%CI=0.84-1.09, P-value=0.52. Asian Illness (Bipolar disorder): OR=1.34, 95%CI=0.35-5.17. European Illness (Bipolar disorder): OR=0.91, 95%CI=0.78-1.06. GG vs. CG+CC: Total: OR=1.01, 95%CI=0.91-1.12, P-value=0.84. Illness types (Bipolar disorder): OR=1.01, 95%CI=0.85-1.21. Ethnicity: Asia: OR=1.10, 95%CI=0.96-1.27; Europe: OR=0.92, 95%CI=0.80-1.07. Asian Illness (Bipolar disorder): OR=1.08, 95%CI=0.84-1.38. European Illness (Bipolar disorder): OR=0.95, 95%CI=0.73-1.23.	The XBP1-116C/G polymorphism is associated with an increased...... The XBP1-116C/G polymorphism is associated with an increased risk of bipolar disorder in Asian population. More...	Positive

Genes reported by this study for BD (count: 1)

Gene	Statistical Values/Author Comments	Result Category
XBP1	The XBP1-116C/G polymorphism is associated with an increased risk of bipolar disorder in Asian popul...... The XBP1-116C/G polymorphism is associated with an increased risk of bipolar disorder in Asian population. More...	Positive

Genetic factors reported by this study for SZ and/or MDD

SNPs reported by this study for SZ/MDD

Disease	SNP	Related Gene(s)	Statistical Values	Description	Result Category
SZ	rs2269577	XBP1	GG vs. CC: Illness types (Schizophrenia): OR=1.15, 95%CI=0.93-1.41. Asian Illness (Schizophrenia): OR=1.24, 95%CI=0.66-2.33. European Illness (Schizophrenia): OR=1.07, 95%CI=0.79-1.45. CG vs. CC: Illness types (Schizophrenia): OR=1.14, 95%CI=0.93-1.40. Asian Illness (Schizophrenia): OR=1.13, 95%CI=0.63-2.04. European Illness (Schizophrenia): OR=1.19, 95%CI=0.88-1.61. GG+CG vs. CC: Illness types (Schizophrenia): OR=1.15, 95%CI=0.94-1.40. Asian Illness (Schizophrenia): OR=1.18, 95%CI=0.66-2.14. European Illness (Schizophrenia): OR=1.13, 95%CI=0.85-1.52. GG vs. CG+CC: Illness types (Schizophrenia): OR=1.01, 95%CI=0.89-1.14. Asian Illness (Schizophrenia): OR=1.11, 95%CI=0.94-1.32. European Illness (Schizophrenia): OR=0.91, 95%CI=0.77-1.08.	No significant association was found.	Negative

Genes reported by this study for SZ/MDD

Disease	Gene	Description	Result Category
SZ	XBP1	No significant association was found.	Negative