SNP Report

Basic Info

Name	rs2273773 dbSNP Ensembl
Location	chr10:67906841 - 67906841(1)
Variant Alleles	T/C
Ancestral Allele	T
Minor Allele	C
Minor Allele Frequence	0.127196
Functional Annotation	non_coding_transcript_exon_variant; non_coding_transcript_variant; synonymous_variant.
Consequence to Transcript	non_coding_transcript_exon_variant(ENST00000473922); non_coding_transcript_variant(ENST00000473922); synonymous_variant(ENST00000212015, ENST00000403579, ENST00000406900, ENST00000432464)
No. of Studies	1 (Positive: 0; Negative: 1; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	NO

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Kishi, T.,2011(a)	T/C		For BP, X² test: genotype, X²(2df)=4.7...... For BP, X² test: genotype, X²(2df)=4.76, P-value = 0.0926; allele, X²(2df)=3.53, P-value = 0.0604 More...	No significant association was observed. No significant association was observed.	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
SIRT1	sirtuin 1	10q21	1(0/1/0)

SNPs in LD with rs2273773 (count: 14) View in gBrowse (chr10:67804053..67911059 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Functional Annotation	r²[population]
rs3818292	downstream_gene_variant; intron_variant	0.932[CHB]; 0.885[JPT]
rs2273771	5_prime_UTR_variant; downstream_gene_variant; NMD_transcript_variant	1.0[CHB]; 1.0[CHD]; 1.0[JPT]
rs10823112	downstream_gene_variant; intron_variant	1.0[CHB]; 1.0[CHD]; 1.0[JPT]
rs10997821	3_prime_UTR_variant; downstream_gene_variant; intron_variant; NMD_transcript_variant	1.0[CHB]; 0.945[CHD]; 1.0[JPT]
rs10823107	intron_variant; non_coding_transcript_variant	0.854[CHB]; 0.903[JPT]
rs3740049	3_prime_UTR_variant; downstream_gene_variant; NMD_transcript_variant; synonymous_variant	1.0[CHB]; 0.945[CHD]; 1.0[JPT]
rs2236319	intron_variant; non_coding_transcript_variant; upstream_gene_variant	1.0[CHB]; 1.0[CHD]; 1.0[JPT]
rs7096385	intron_variant; non_coding_transcript_variant; upstream_gene_variant	1.0[CHB]; 1.0[JPT]
rs12049646		1.0[CHB]; 1.0[JPT]
rs3740051	upstream_gene_variant	1.0[CHB]; 0.916[CHD]; 0.9[JPT]
rs10509291	downstream_gene_variant	1.0[CHB]; 1.0[CHD]; 1.0[JPT]
rs10823108	intron_variant; non_coding_transcript_variant	1.0[CHB]; 1.0[CHD]; 1.0[JPT]
rs10997817	downstream_gene_variant; intron_variant; upstream_gene_variant	1.0[CHB]; 0.945[CHD]; 1.0[JPT]
rs12360521	downstream_gene_variant	1.0[CHB]; 0.949[JPT]

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Kishi, T.,2011(a)	For SZ, X² test:genotype, X²(2df)=0.0744, P-value = 0.963;allele, X²(2df)=0.0644, P-value = 0.8	No significant association was observed.	Negative

Overlap with MDD from cross-disorder studies (count: 0)