BDgene

SNP Report

Basic Info
Name rs947267 dbSNP Ensembl
Location chr13:105487313 - 105487313(1)
Variant Alleles T/G
Ancestral Allele G
Minor Allele G
Minor Allele Frequence 0.486621
Functional Annotation intron_variant; NMD_transcript_variant; non_coding_transcript_variant.
Consequence to Transcript intron_variant(ENST00000329625, ENST00000375936, ENST00000448407, ENST00000471432, ENST00000473269, ENST00000488534, ENST00000489237, ENST00000559369, ENST00000595812, ENST00000600388, ENST00000601240, ENST00000618629); NMD_transcript_variant(ENST00000471432, ENST00000473269, ENST00000488534, ENST00000489237, ENST00000559369, ENST00000595812, ENST00000600388, ENST00000601240); non_coding_transcript_variant(ENST00000448407)
No. of Studies 9 (Positive: 1; Negative: 8; Trend: 0)
Source Literature
Overlap with SZ? YES
Overlap with MDD? YES

SNP related studies (count: 9)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Muller, D. J.,2011 G/T FBAT: for total sample, variance of the S-statistic=69.8, Z-...... FBAT: for total sample, variance of the S-statistic=69.8, Z-score=1.14, P-value = 0.25; for European sample, variance of the S-statistic=65.1, Z-score=1.49, P-value = 0.14; for BD patients with psychotic symptoms, variance of the S-statistic=34.8, Z-score=0.59, P-value = 0.55; for BD patients without psychotic symptoms, variance of the S-statistic=22.3, Z-score=0.95, P-value = 0.34 More... No significant association was observed. No significant association was observed. Negative
Gawlik, M.,2010 C/A Armitage's trend test: P-value = 0.64 Armitage's trend test: P-value = 0.64 No significant association was observed in BD. No significant association was observed in BD. Negative
Tan, J., 2014 C/A C vs. A: OR= 0.98; 95%CI= 0.89–1.09; P-value = 0.739 C vs. A: OR= 0.98; 95%CI= 0.89–1.09; P-value = 0.739 We failed to obtain a significant association between M18 an...... We failed to obtain a significant association between M18 and BD More... Negative
Gaysina, D.,2010 A/C chi-squared tests: allele P-value = 0.56 for UK sample; alle...... chi-squared tests: allele P-value = 0.56 for UK sample; allele P-value = 0.73 for Canadian sample. More... No significant association was observed in BD. No significant association was observed in BD. Negative
Chen, Y. S.,2004 A/C Single-marker association results: Likelihood ratio statisti...... Single-marker association results: Likelihood ratio statistic is 4.2057, P-value = 0.0403, OR=0.69 More... Significant association was found in BD. Significant association was found in BD. Positive
Hattori, E.,2003 A/C A Association analysis: for CNG pedigrees, TDT P-value = 0.17,...... Association analysis: for CNG pedigrees, TDT P-value = 0.17, Transmission Ratio=0.7; for NIMH pedigrees, TDT P-value = 0.58, Transmission Ratio=0.48 More... No significant association was observed in BD. No significant association was observed in BD. Negative
Maheshwari, M.,2009 A/C TDT: Raw TDT P-value = 0.251, Adaptive permutation corrected...... TDT: Raw TDT P-value = 0.251, Adaptive permutation corrected P-value = 0.875 More... No significant allelic association with BP was found No significant allelic association with BP was found Negative
Detera-Wadleigh, S. D., 2006 A/C Fisher P-value = 0.2256 for all, P-value = 0.2513 for BP Onl...... Fisher P-value = 0.2256 for all, P-value = 0.2513 for BP Only More... Negative
Bass, N. J.,2009 A/C chi-squared tests: for BP, allele, X2(1 d.f.)=0.3...... chi-squared tests: for BP, allele, X2(1 d.f.)=0.362, P-value = 0.548 More... No significant association was observed. No significant association was observed. Negative

SNP related genes (count: 2)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
DAOA-AS1 DAOA antisense RNA 1 13q33.2 Mapped by Literature SNP
DAOA D-amino acid oxidase activator 13q33.2 21(13/7/1)

SNPs in LD with rs947267 (count: 3) View in gBrowse (chr13:105477549..105487313 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 3)


Overlap with SZ from cross-disorder studies (count: 3)
Reference Statistical Result Description Result Category
Bass, N. J.,2009 chi-squared tests:for SCZ, allele, X2(1 d.f.)=0.203, P-value = 0.652 No significant association was observed. Negative
Detera-Wadleigh, S. D., 2006 Fisher P-value = 0.2256 for all, P-value = 0.9478 for SCZ Only Negative
Tan, J., 2014 C vs. A: OR = 1.00, 95% CI = 0.89–1.11, P-value = 0.98; CC+CA vs. AA: OR = 0.97, 95% CI = 0.84–1.12, P-value = 0.675; CC vs. CA+AA: OR = 1.00, 95% CI= 0.87–1.15, P-value = 0.998; CC vs. CA: OR=1.01, 95% CI= 0.88–1.17, P-value = 0.864; CA vs. AA: OR= 0.97, 95%CI= 0.87–1.08, P-value = 0.584; CC vs. AA: OR= 0.98, 95% CI= 0.78–1.24, P-value = 0.857 The pooled ORs failed to suggest that M18 was significantly associated with SCZ in six models Negative

Overlap with MDD from cross-disorder studies (count: 2)
Reference Statistical Result Description Result Category
Tan, J., 2014 C vs. A: OR= 1.05, 95% CI = 0.91–1.22, P-value = 0.476; CC+CA vs. AA: OR = 1.09, 95%CI = 0.88–1.34, P-value = 0.43; CC vs. CA+AA: OR = 1.05, 95% CI = 0.79–1.40, P-value = 0.748; CC vs. CA: OR = 1.01, 95% CI = 0.75–1.37, P-value = 0.941; CA vs. AA: OR = 1.08, 95% CI = 0.87–1.35, P-value = 0.475; CC vs. AA: OR= 1.10, 95% CI= 0.80–1.51, P-value = 0.544. No significant association was found between M18 and DD in six models. Negative
Gawlik, M.,2010 Armitage's trend test:P-value = 0.99 No significant association was observed. Negative