BDgene

Study Report

Basic Info
Reference
Citation Hashimoto, R., T. Suzuki, et al. (2005). Association study of the frizzled-3 (FZD3) gene with schizophrenia and mood disorders. J Neural Transm 112(2): 303-307.
Disease Type Bipolar Disorder & Schizophrenia & Major Depressive Disorder
Study Design case-control
Study Type Candidate-gene association study
Sample Size 427 patients with schizophrenia,91 with bipolar disorder,396 with major depression and 473 healthy controls
SNP/Region/Marker Size 4 SNPs
Predominant Ethnicity Mongloid
Population Japanese
Gender 221 males and 206 females in patients with schizophrenia,40 and 51 in patients with bipolar disorder ,155 and 241 in patients with major depression ,228 and 245 in healthy controls
Age Group Adults : mean age:44.2 years [SD 14.5] in patients with schizophrenia,53.6 years [SD 14.8] in patients with bipolar disorder ,53.4 years [SD 16.1] in patients with major depression ,36.1 years [SD 12.5] in healthy controls

Detail Info

Genetic factors reported by this study for BD
SNPs reported by this study for BD (count: 4)

Haplotypes reported by this study for BD (count: 1)

Genes reported by this study for BD (count: 1)

Genetic factors reported by this study for SZ and/or MDD
SNPs reported by this study for SZ/MDD
Disease SNP Related Gene(s) Statistical Values Description Result Category
SZ rs2241802 FZD3 RNA5SP259 Allelic association:P-value = 0.85 for SZ No significant association was observed in SZ. Negative
SZ rs960914 FZD3 MIR4288 Allelic association:P-value = 0.91 for SZ No significant association was observed in SZ. Negative
SZ rs2323019 FZD3 RNA5SP259 Allelic association:P-value = 0.57 for SZ No significant association was observed in SZ. Negative
SZ rs352203 FZD3 Allelic association:P-value = 0.97 for SZ No significant association was observed in SZ. Negative
MDD rs2241802 FZD3 RNA5SP259 Allelic association:P-value = 0.96 for MDD No association was observed in MDD. Negative
MDD rs960914 FZD3 MIR4288 Allelic association:P-value = 0.61 for MDD No association was observed in MDD. Negative
MDD rs2323019 FZD3 RNA5SP259 Allelic association:P-value = 0.91 for MDD No association was observed in MDD. Negative
MDD rs352203 FZD3 Allelic association:P-value = 0.64 for MDD No association was observed in MDD. Negative

Haplotypes reported by this study for SZ/MDD
Disease Markers Haplotype Related Gene(s)/Region(s) Statistical Values Description Result Category
SZ rs960914 - rs2241802 - rs2323019 - rs352203 FZD3 Haplotypic association:global P-values>0.2 No significant association was found . Negative
MDD rs960914 - rs2241802 - rs2323019 - rs352203 FZD3 Haplotypic association:global P-values>0.2 No significant association was found . Negative

Genes reported by this study for SZ/MDD
Disease Gene Description Result Category
SZ FZD3 In conclusion, we obtained no evidence for an association between the FZD3 gene and schizophrenia or mood disorders, suggesting that this gene has no major role in conferring susceptibility to major psychoses in our sample. Negative
MDD FZD3 In conclusion, we obtained no evidence for an association between the FZD3 gene and schizophrenia or mood disorders, suggesting that this gene has no major role in conferring susceptibility to major psychoses in our sample. Negative