BDgene

SNP Report

Basic Info
Name rs2168351 dbSNP Ensembl
Location chr15:92440492 - 92440492(1)
Variant Alleles A/G
Ancestral Allele A
Minor Allele G
Minor Allele Frequence 0.371206
Functional Annotation intron_variant; non_coding_transcript_variant.
Consequence to Transcript intron_variant(ENST00000268164, ENST00000539113, ENST00000555434, ENST00000556382); non_coding_transcript_variant(ENST00000556382)
No. of Studies 2 (Positive: 2; Negative: 0; Trend: 0)
Source Literature
Overlap with SZ? YES
Overlap with MDD? NO

SNP related studies (count: 2)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
McAuley, E. Z., 2012 G/A P-value = 0.005, Empirical P-value = 0.007, OR (95% CI)=0.65...... P-value = 0.005, Empirical P-value = 0.007, OR (95% CI)=0.65 (0.49-0.89) in the Australian bipolar disorder cohort More... Nominally significant association (P < 0.05) was found with ...... Nominally significant association (P < 0.05) was found with 18 SNPs. Association with 14 of these SNPs held true when empirical P values were obtained through 10, 000 replicate permutations. More... Positive
Yang, S. Y., 2015 P-value=0.030, OR=1.483, 95%CI=1.038-2.120 P-value=0.030, OR=1.483, 95%CI=1.038-2.120 BD-I showed nominally significant associations with rs375991...... BD-I showed nominally significant associations with rs3759915, rs4777969, rs11637898, rs4777980, rs8037133, and rs2168351 under the dominant and additive models, and with rs8025225 under the recessive model. More... Positive

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 15q26 2(2/0/0)

SNPs in LD with rs2168351 (count: 19) View in gBrowse (chr15:92436217..92447112 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 19)


Overlap with SZ from cross-disorder studies (count: 1)
Reference Statistical Result Description Result Category
McAuley, E. Z., 2012 P-value > 0.075 Single SNP analysis did not yield significant evidence for association. Negative

Overlap with MDD from cross-disorder studies (count: 0)

Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback Acknowledgements
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Last update: March 31, 2016