BDgene

SNP Report

Basic Info
Name rs8192625 dbSNP Ensembl
Location chr6:132571193 - 132571193(1)
Variant Alleles G/A
Ancestral Allele A
Minor Allele A
Minor Allele Frequence 0.0617013
Functional Annotation missense_variant.
Polyphen Annotation: benign(ENST00000275198)
SIFT Annotation: tolerated(ENST00000275198)
Consequence to Transcript missense_variant(ENST00000275198)
No. of Studies 4 (Positive: 1; Negative: 3; Trend: 0)
Source Literature
Overlap with SZ? YES
Overlap with MDD? NO

SNP related studies (count: 4)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Venken, T., 2006 P-value > 0.05 P-value > 0.05 The analysis revealed no significant associations between bi...... The analysis revealed no significant associations between bipolar disorder patients and control individuals. More... Negative
Pae, C. U., 2008 T/C C Allele frequency (BID vs.control) 0.01 vs. 0.01; P-value > ...... Allele frequency (BID vs.control) 0.01 vs. 0.01; P-value > 0.05 More... Negative
Liu, C., 2007 A/G TDT P-value = 0.16 in CNG+NIMH waves I+2, TDT P-value = 0.09...... TDT P-value = 0.16 in CNG+NIMH waves I+2, TDT P-value = 0.099 in NIMH waves 3+4 + CHIP, TDT P-value = 0.018 in Entire sample More... it showed P not greater than 0.05 only in combined data anal...... it showed P not greater than 0.05 only in combined data analysis; we observed nominally significant association between minor allele (A) and BD More... Positive
Abou Jamra, R.,2005(b) G/A In family base study: TDT P-value = 0.063; in case-control s...... In family base study: TDT P-value = 0.063; in case-control study: ARMITAGES TREND TEST P-values (odds ratio, 95% CI)=0.250 (1.36, 0.87-2.15). More... No significant association was observed. No significant association was observed. Negative

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
TAAR6 trace amine associated receptor 6 6q23.1 5(4/1/0)

SNPs in LD with rs8192625 (count: 2) View in gBrowse (chr6:132571193..132580331 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 2)


Overlap with SZ from cross-disorder studies (count: 1)
Reference Statistical Result Description Result Category
Pae, C. U., 2008 Allele frequency (SZ vs.control) 0.02 vs. 0.01; P-value > 0.05 Negative

Overlap with MDD from cross-disorder studies (count: 0)