SNP Report

Basic Info

Name	rs8192625 dbSNP Ensembl
Location	chr6:132571193 - 132571193(1)
Variant Alleles	G/A
Ancestral Allele	A
Minor Allele	A
Minor Allele Frequence	0.0617013
Functional Annotation	missense_variant. Polyphen Annotation: benign(ENST00000275198) SIFT Annotation: tolerated(ENST00000275198)
Consequence to Transcript	missense_variant(ENST00000275198)
No. of Studies	4 (Positive: 1; Negative: 3; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	NO

SNP related studies (count: 4)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Venken, T., 2006			P-value > 0.05 P-value > 0.05	The analysis revealed no significant associations between bi...... The analysis revealed no significant associations between bipolar disorder patients and control individuals. More...	Negative
Pae, C. U., 2008	T/C	C	Allele frequency (BID vs.control) 0.01 vs. 0.01; P-value > ...... Allele frequency (BID vs.control) 0.01 vs. 0.01; P-value > 0.05 More...		Negative
Liu, C., 2007	A/G		TDT P-value = 0.16 in CNG+NIMH waves I+2, TDT P-value = 0.09...... TDT P-value = 0.16 in CNG+NIMH waves I+2, TDT P-value = 0.099 in NIMH waves 3+4 + CHIP, TDT P-value = 0.018 in Entire sample More...	it showed P not greater than 0.05 only in combined data anal...... it showed P not greater than 0.05 only in combined data analysis; we observed nominally significant association between minor allele (A) and BD More...	Positive
Abou Jamra, R.,2005(b)	G/A		In family base study: TDT P-value = 0.063; in case-control s...... In family base study: TDT P-value = 0.063; in case-control study: ARMITAGES TREND TEST P-values (odds ratio, 95% CI)=0.250 (1.36, 0.87-2.15). More...	No significant association was observed. No significant association was observed.	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
TAAR6	trace amine associated receptor 6	6q23.1	5(4/1/0)

SNPs in LD with rs8192625 (count: 2) View in gBrowse (chr6:132571193..132580331 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Literature-origin SNPs with LD	Functional Annotation	r²[population]
rs7764564			1.0[CHD]; 1.0[JPT]
rs6937423			1.0[CHD]; 1.0[JPT]

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Pae, C. U., 2008	Allele frequency (SZ vs.control) 0.02 vs. 0.01; P-value > 0.05		Negative

Overlap with MDD from cross-disorder studies (count: 0)