BDgene

SNP Report

Basic Info
Name rs1935062 dbSNP Ensembl
Location chr13:105475787 - 105475787(1)
Variant Alleles A/C
Ancestral Allele A
Minor Allele C
Minor Allele Frequence 0.377596
Functional Annotation intron_variant; NMD_transcript_variant; non_coding_transcript_variant.
Consequence to Transcript intron_variant(ENST00000329625, ENST00000375936, ENST00000448407, ENST00000471432, ENST00000473269, ENST00000488534, ENST00000489237, ENST00000559369, ENST00000595812, ENST00000600388, ENST00000601240, ENST00000618629); NMD_transcript_variant(ENST00000471432, ENST00000473269, ENST00000488534, ENST00000489237, ENST00000559369, ENST00000595812, ENST00000600388, ENST00000601240); non_coding_transcript_variant(ENST00000448407)
No. of Studies 12 (Positive: 6; Negative: 6; Trend: 0)
Source Literature
Overlap with SZ? YES
Overlap with MDD? YES

SNP related studies (count: 12)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Schumacher, J.,2004 A/C Association analysis: allele P-value = 0.715, OR=1.05, genot...... Association analysis: allele P-value = 0.715, OR=1.05, genotype P-value = 0.085, OR=1.57 More... No significant association was observed in BD. No significant association was observed in BD. Negative
Hukic, D. S.,2013 C/A BP1 CMS vs. ABD controls: P-value = 0.069,empirical p-value ...... BP1 CMS vs. ABD controls: P-value = 0.069,empirical p-value =0.066,empirical p-value2 = 0.52,OR[95%CI] = 0.8[0.65–1.0] More... Significant association was observed. Significant association was observed. Positive
Hattori, E.,2003 A/C A Association analysis: for CNG pedigrees, TDT P-value = 0.007...... Association analysis: for CNG pedigrees, TDT P-value = 0.0078, Transmission Ratio=0.11; for NIMH pedigrees, TDT P-value = 0.38, Transmission Ratio=0.43 More... Significant association was found in BD. Significant association was found in BD. Positive
Chen, Y. S.,2004 A/C Single-marker association results: Likelihood ratio statisti...... Single-marker association results: Likelihood ratio statistic is 7.2236, P-value = 0.0072, OR=1.67 More... Significant association was found in BD. Significant association was found in BD. Positive
Bass, N. J.,2009 A/C chi-squared tests: for BP, allele, X2(1 d.f.)=0.0...... chi-squared tests: for BP, allele, X2(1 d.f.)=0.011, P-value = 0.917 More... No significant association was observed. No significant association was observed. Negative
Gaysina, D.,2010 A/C chi-squared tests: allele P-value = 0.86 for UK sample; alle...... chi-squared tests: allele P-value = 0.86 for UK sample; allele P-value = 0.67 for Canadian sample. More... No significant association was observed in BD. No significant association was observed in BD. Negative
Muller, D. J.,2011 C/A FBAT: for total sample, variance of the S-statistic=60.5, Z-...... FBAT: for total sample, variance of the S-statistic=60.5, Z-score=-2.33, P-value = 0.02; for European sample, variance of the S-statistic=56.5, Z-score=-2.54, P-value = 0.01; for BD patients with psychotic symptoms, variance of the S-statistic=29, Z-score=-1.49, P-value = 0.14; for BD patients without psychotic symptoms, variance of the S-statistic=18.5, Z-score=-0.7, P-value = 0.49 More... Significant association was found in both BD total sample an...... Significant association was found in both BD total sample and BD European sample. More... Positive
Maheshwari, M.,2009 A/C TDT: Raw TDT P-value = 0.448, Adaptive permutation corrected...... TDT: Raw TDT P-value = 0.448, Adaptive permutation corrected P-value = 0.813 STEPC: sib_tdt P-value = 0.039, TG P-value = 0.03 More... No significant allelic association with BP was found, but as...... No significant allelic association with BP was found, but association underlies the previously observed linkage signals in the CNGsample set was found. More... Positive
Shi, J., 2008 (a) C OR (95% CI)=1.02 (0.60-1.76) , Z test P-value = 0.93 for Eu...... OR (95% CI)=1.02 (0.60-1.76) , Z test P-value = 0.93 for European samples. More... No single maker showed evidence of overall association with ...... No single maker showed evidence of overall association with BP. More... Negative
Grigoroiu-Serbanescu, M.,2010 A/C Allelic association analysis: for non-psychotic patients, P-...... Allelic association analysis: for non-psychotic patients, P-value = 0.115, OR(95%CI)=1.63(0.90-2.92); for psychotic patients, P-value = 0.657, OR(95%CI)=0.93(0.68-1.27) More... No significant association was observed in BD. No significant association was observed in BD. Negative
Detera-Wadleigh, S. D., 2006 A/C Fisher P-value = 0.0143 for all, P-value = 0.0019 for BP Onl...... Fisher P-value = 0.0143 for all, P-value = 0.0019 for BP Only More... When results are combined across studies and phenotypes, thi...... When results are combined across studies and phenotypes, this marker showed significant combined p value. Only three studies have been published in bipolar-disorder samples, but significant (p<0.05) combined results are seen for three markers spanning more than 74 kb. More... Positive
Gawlik, M.,2010 A/C Armitage's trend test: P-value = 0.94 Armitage's trend test: P-value = 0.94 No significant association was observed in BD. No significant association was observed in BD. Negative

SNP related genes (count: 2)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
DAOA-AS1 DAOA antisense RNA 1 13q33.2 Mapped by Literature SNP
DAOA D-amino acid oxidase activator 13q33.2 21(13/7/1)

SNPs in LD with rs1935062 (count: 0) View in gBrowse (chr13:105475787..105475787 )

Overlap with SZ from cross-disorder studies (count: 2)
Reference Statistical Result Description Result Category
Schumacher, J.,2004 Association analysis:allele P-value = 0.494, OR=1.09, genotype P-value = 0.45, OR=1.21 No significant association was observed in SZ. Negative
Detera-Wadleigh, S. D., 2006 Fisher P-value = 0.0143 for all, P-value = 0.9804 for SCZ Only When results are combined across studies and phenotypes, this marker showed significant combined p value. Combined results in schizophrenia are significant for several markers. Positive

Overlap with MDD from cross-disorder studies (count: 1)
Reference Statistical Result Description Result Category
Gawlik, M.,2010 Armitage's trend test:P-value = 0.6 No significant association was observed. Negative