BDgene

SNP Report

Basic Info
Name rs553950 dbSNP Ensembl
Location chr8:31933846 - 31933846(1)
Variant Alleles T/G
Ancestral Allele G
Minor Allele T
Minor Allele Frequence 0.198283
Functional Annotation intron_variant.
Consequence to Transcript intron_variant(ENST00000518104, ENST00000519301, ENST00000520407, ENST00000523534)
No. of Studies 2 (Positive: 2; Negative: 0; Trend: 0)
Source Literature
Overlap with SZ? YES
Overlap with MDD? NO

SNP related studies (count: 2)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Walker, R. M.,2010 X2 test: P-value = 0.028 for Scottish 1, P-value ...... X2 test: P-value = 0.028 for Scottish 1, P-value = 0.95 for Scottish 2, P-value = 0.11 for merged Scottish More... Significant association was found in BD. Significant association was found in BD. Positive
Thomson, P. A., 2007 Individual P-value = 0.0287 for BP, Individual P-value = 0.0...... Individual P-value = 0.0287 for BP, Individual P-value = 0.0109 for SCZ and BP More... This SNP is nominally significant in all three groups: BP, S...... This SNP is nominally significant in all three groups: BP, SCZ and combined. More... Positive

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
NRG1 neuregulin 1 8p12 15(10/5/0)

SNPs in LD with rs553950 (count: 46) View in gBrowse (chr8:31923712..31953462 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 46)


Overlap with SZ from cross-disorder studies (count: 2)
Reference Statistical Result Description Result Category
Thomson, P. A., 2007 Individual P-value = 0.0288 for SCZ , Individual P-value = 0.0109 for SCZ and BP This SNP is nominally significant in all three groups: BP, SCZ and combined. Positive
Walker, R. M.,2010 X2 test:P-value = 0.028 for Scottish 1, P-value = 0.99 for Scottish 2, P-value = 0.093 for merged Scottish Significant association was found. Positive

Overlap with MDD from cross-disorder studies (count: 0)

Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback Acknowledgements
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Last update: March 31, 2016