BDgene

Study Report

Basic Info
Reference
Citation Severinsen, J. E., C. R. Bjarkam, et al. (2006). "Evidence implicating BRD1 with brain development and susceptibility to both schizophrenia and bipolar affective disorder." Mol Psychiatry 11(12): 1126-1138.
Disease Type Bipolar Disorder & Schizophrenia
Study Design case-control
Study Type Candidate-gene association study
Sample Size 103 patients with SZ, 162 patients with BPD and 200 ethnically matched controls
SNP/Region/Marker Size 16 variants
Predominant Ethnicity Caucasian
Population Scottish

Detail Info

Genetic factors reported by this study for BD
SNPs reported by this study for BD (count: 13)

Haplotypes reported by this study for BD (count: 45)

Other variants reported by this study for BD (count: 2)

Genes reported by this study for BD (count: 4)

Gene-gene interactions reported by this study for BD (count: 4)

Genetic factors reported by this study for SZ and/or MDD
SNPs reported by this study for SZ/MDD
Disease SNP Related Gene(s) Statistical Values Description Result Category
SZ rs916005 MAPK8IP2 CHKB P-value = 0.8482 in SZ, P-value = 1 in BD and SZ Negative
SZ rs4468 BRD1 P-value = 0.0088 in SZ, P-value = 0.0215 in BD and SZ SNP rs4468 and D22S1169 showed significant association with SZ but not with BPD. Positive
SZ rs3810971 MOV10L1 P-value = 0.3431 in SZ, P-value = 0.9874 in BD and SZ Negative
SZ rs715519 MAPK8IP2 CHKB P-value = 0.7254 in SZ, P-value = 0.7976 in BD and SZ Negative
SZ rs6010260 MLC1 P-value = 0.0823 in SZ, P-value = 0.1631 in BD and SZ Negative
SZ rs138880 BRD1 P-value = 0.0061 in SZ, P-value = 0.0046 in BD and SZ The promoter SNP rs138880 showed association in SZ and the combined case group. Positive
SZ rs138881 BRD1 P-value = 0.2896 in SZ, P-value = 0.1727 in BD and SZ Negative
SZ rs2239848 BRD1 P-value = 1 in SZ, P-value = 0.3983 in BD and SZ Negative
SZ rs2272843 MOV10L1 P-value = 0.2701 in SZ, P-value = 0.3018 in BD and SZ Negative
SZ rs132234 FAM19A5 P-value = 0.7013 in SZ, P-value = 0.6116 in BD and SZ Negative
SZ rs137931 MOV10L1 MLC1 P-value = 0.844 in SZ, P-value = 0.5796 in BD and SZ Negative
SZ rs137932 MOV10L1 MLC1 P-value = 0.7615 in SZ, P-value = 0.6327 in BD and SZ Negative
SZ rs138855 BRD1 P-value = 0.501 in SZ, P-value = 0.4186 in BD and SZ Negative

Haplotypes reported by this study for SZ/MDD
Disease Markers Haplotype Related Gene(s)/Region(s) Statistical Values Description Result Category
SZ rs138880 - rs2239848 - rs138855 - rs4468 BRD1 P-value = 0.0203 in SZ, P-value = 0.0607 in BD and SZ Positive
SZ rs138880 - rs2239848 - rs138855 BRD1 P-value = 0.00001 in SZ, P-value = 0.00005 in BD and SZ Highly significant overall P-values (as low as 0.00001) were observed in especially the 3- and 4-marker analysis involving the BRD1 SNPs rs138855, rs2239848, rs138880 and rs138881. Positive
SZ rs138881 - rs138880 - rs2239848 BRD1 P-value = 0.1358 in SZ, P-value = 0.155 in BD and SZ Negative
SZ rs138881 - rs138880 BRD1 P-value = 0.0521 in SZ, P-value = 0.0681 in BD and SZ Negative
SZ rs138855 - rs4468 - D22S1169 BRD1 P-value = 0.0117 in SZ, P-value = 0.1374 in BD and SZ Negative
SZ rs138855 - rs4468 BRD1 P-value = 0.1138 in SZ, P-value = 0.3182 in BD and SZ Negative
SZ rs138880 - rs2239848 BRD1 P-value = 0.161 in SZ, P-value = 0.0381 in BD and SZ Positive
SZ rs138855 - rs4468 - D22S1169 - D22S922 BRD1 P-value = 0.0839 in SZ, P-value = 0.1149 in BD and SZ Negative
SZ rs138855 - rs138880 - rs138881 G-C-G BRD1 P-value = 0.0015 in BD, P-value = 0.0022 in BD and SZ Positive
SZ rs138855 - rs138880 - rs138881 G-C-A BRD1 P-value = 2E-04 in BD, P-value = 4E-05 in BD and SZ Positive
SZ rs138855 - rs2239848 - rs138880 - rs138881 G-G-C-A BRD1 P-value = 2E-04 in BD, P-value = 2E-05 in BD and SZ Positive
SZ rs138855 - rs2239848 - rs138880 G-G-C BRD1 P-value = 4E-06 in BD, P-value = 1E-06 in BD and SZ A 3-marker core haplotype spanning BRD1 SNPs rs138855, rs2239848 and rs138880 had a frequency of around 9% in cases against only 1% in controls, producing a haplotype specific P-value of order 1E-06. Positive
SZ rs138855 - rs138880 G-C BRD1 P-value = 1E-06 in BD, P-value = 2.8E-07 in BD and SZ Removing the rare middle SNP rs2239848 from the analysis resulted in a reduced 2-marker 'risk' haplotype (G-C) showing a frequency of ~10% in cases versus ~1% in controls. Positive
SZ D22S922 - D22S1169 - rs4468 2-3-C BRD1 P-value = 0.0120 in BD and SZ Positive
SZ rs715519 - rs2272843 - rs3810971 - rs137932 MAPK8IP2 MOV10L1 P-value = 0.5239 in SZ, P-value = 0.4123 in BD and SZ Negative
SZ rs916005 - rs715519 - rs2272843 MAPK8IP2 MOV10L1 P-value = 0.9187 in SZ, P-value = 0.9786 in BD and SZ Negative
SZ rs916005 - rs715519 - rs2272843 - rs3810971 MAPK8IP2 MOV10L1 P-value = 0.7463 in SZ, P-value = 0.7152 in BD and SZ Negative
SZ rs137931 - rs6010260 MLC1 P-value = 0.1836 in SZ, P-value = 0.1604 in BD and SZ Negative
SZ D22S922 - rs132234 FAM19A5 P-value = 0.595 in SZ, P-value = 0.5738 in BD and SZ Negative
SZ rs916005 - rs715519 MAPK8IP2 P-value = 0.9765 in SZ, P-value = 0.9552 in BD and SZ Negative
SZ rs715519 - rs2272843 MAPK8IP2 MOV10L1 P-value = 0.6423 in SZ, P-value = 0.7516 in BD and SZ Negative
SZ rs715519 - rs2272843 - rs3810971 MAPK8IP2 MOV10L1 P-value = 0.5626 in SZ, P-value = 0.4568 in BD and SZ Negative
SZ rs4468 - D22S1169 BRD1 P-value = 0.0184 in SZ, P-value = 0.3317 in BD and SZ Positive
SZ rs4468 - D22S1169 - D22S922 BRD1 P-value = 0.0657 in SZ, P-value = 0.403 in BD and SZ Negative
SZ rs4468 - D22S1169 - D22S922 - rs132234 BRD1 FAM19A5 P-value = 0.0228 in SZ, P-value = 0.1853 in BD and SZ Positive
SZ D22S1169 - D22S922 - rs132234 FAM19A5 P-value = 0.0426 in SZ, P-value = 0.4635 in BD and SZ Positive
SZ rs138881 - rs138880 - rs2239848 - rs138855 BRD1 P-value = 0.0002 in SZ, P-value = 0.0003 in BD and SZ Highly significant overall P-values (as low as 0.00001) were observed in especially the 3- and 4-marker analysis involving the BRD1 SNPs rs138855, rs2239848, rs138880 and rs138881. Positive
SZ rs2239848 - rs138855 BRD1 P-value = 0.5944 in SZ, P-value = 0.6658 in BD and SZ Negative
SZ rs2239848 - rs138855 - rs4468 BRD1 P-value = 0.047 in SZ, P-value = 0.2092 in BD and SZ Positive
SZ rs2239848 - rs138855 - rs4468 - D22S1169 BRD1 P-value = 0.0095 in SZ, P-value = 0.263 in BD and SZ Positive
SZ D22S1169 - D22S922 P-value = 0.0194 in SZ, P-value = 0.427 in BD and SZ Positive
SZ rs3810971 - rs137932 - rs137931 - rs6010260 MOV10L1 MLC1 P-value = 0.1839 in SZ, P-value = 0.2924 in BD and SZ Negative
SZ rs3810971 - rs137932 - rs137931 MOV10L1 MLC1 P-value = 0.9061 in SZ, P-value = 0.8355 in BD and SZ Negative
SZ rs3810971 - rs137932 MOV10L1 MLC1 P-value = 0.8971 in SZ, P-value = 0.9882 in BD and SZ Negative
SZ rs2272843 - rs3810971 - rs137932 - rs137931 MOV10L1 MLC1 P-value = 0.7849 in SZ, P-value = 0.4295 in BD and SZ Negative
SZ rs2272843 - rs3810971 - rs137932 MOV10L1 MLC1 P-value = 0.7132 in SZ, P-value = 0.4691 in BD and SZ Negative
SZ rs2272843 - rs3810971 MOV10L1 P-value = 0.3417 in SZ, P-value = 0.1966 in BD and SZ Negative
SZ rs6010260 - rs138881 - rs138880 - rs2239848 MLC1 BRD1 P-value = 0.1593 in SZ, P-value = 0.3086 in BD and SZ Negative
SZ rs6010260 - rs138881 - rs138880 MLC1 BRD1 P-value = 0.0763 in SZ, P-value = 0.2102 in BD and SZ Negative
SZ rs6010260 - rs138881 MLC1 BRD1 P-value = 0.3103 in SZ, P-value = 0.4043 in BD and SZ Negative
SZ rs137932 - rs137931 - rs6010260 - rs138881 MLC1 BRD1 P-value = 0.4183 in SZ, P-value = 0.3061 in BD and SZ Negative
SZ rs137931 - rs6010260 - rs138881 - rs138880 MLC1 BRD1 P-value = 0.11 in SZ, P-value = 0.2358 in BD and SZ Negative
SZ rs137931 - rs6010260 - rs138881 MLC1 BRD1 P-value = 0.3326 in SZ, P-value = 0.1926 in BD and SZ Negative
SZ rs137932 - rs137931 - rs6010260 MLC1 P-value = 0.2821 in SZ, P-value = 0.4051 in BD and SZ Negative
SZ rs137932 - rs137931 MLC1 P-value = 0.8969 in SZ, P-value = 0.921 in BD and SZ Negative

Other variants reported by this study for SZ/MDD
Disease Variant Name Related Gene Type Statistical Values Description Result Category
SZ D22S1169 microsatellite P-value = 0.0214 in SZ, P-value = 0.0383 in BD and SZ SNP rs4468 and D22S1169 showed significant association with SZ. Positive
SZ D22S922 microsatellite P-value = 0.3501 in SZ, P-value = 0.5552 in BD and SZ Negative

Genes reported by this study for SZ/MDD
Disease Gene Description Result Category
SZ MLC1 The results do not support an association of the gene with SZ. Negative
SZ MOV10L1 The results do not support an association of the gene with SZ. Negative
SZ MAPK8IP2 The results do not support an association of the gene with SZ. Negative
SZ BRD1 The results implicate BRD1 with SZ and BPD susceptibility and provide evidence that suggests a role for BRD1 in neurodevelopment. Positive

Gene-gene interactions reported by this study for SZ/MDD
Disease Gene Group Markers Statistical Values Description Result Category
SZ rs4468 - D22S1169 - D22S922 - rs132234 P-value = 0.0228 in SZ, P-value = 0.1853 in BD and SZ Positive
SZ rs715519 - rs2272843; rs715519 - rs2272843 - rs3810971; rs916005 - rs715519 - rs2272843; rs715519 - rs2272843 - rs3810971 - rs137932; rs916005 - rs715519 - rs2272843 - rs3810971 For markers "rs715519 - rs2272843", P-value = 0.6423 in SZ, P-value = 0.7516 in BD and SZ; For markers "rs715519 - rs2272843 - rs3810971", P-value = 0.5626 in SZ, P-value = 0.4568 in BD and SZ; For markers "rs916005 - rs715519 - rs2272843", P-value = 0.9187 in SZ, P-value = 0.9786 in BD and SZ; For markers "rs715519 - rs2272843 - rs3810971 - rs137932", P-value = 0.5239 in SZ, P-value = 0.4123 in BD and SZ; For markers "rs916005 - rs715519 - rs2272843 - rs3810971", P-value = 0.7463 in SZ, P-value = 0.7152 in BD and SZ. Negative
SZ rs6010260 - rs138881; rs6010260 - rs138881 - rs138880; rs137931 - rs6010260 - rs138881; rs6010260 - rs138881 - rs138880 - rs2239848; rs137931 - rs6010260 - rs138881 - rs138880; rs137932 - rs137931 - rs6010260 - rs138881 For markers "rs6010260 - rs138881", P-value = 0.3103 in SZ, P-value = 0.4043 in BD and SZ; For markers "rs6010260 - rs138881 - rs138880", P-value = 0.0763 in SZ, P-value = 0.2102 in BD and SZ; For markers "rs137931 - rs6010260 - rs138881", P-value = 0.3326 in SZ, P-value = 0.1926 in BD and SZ; For markers "rs6010260 - rs138881 - rs138880 - rs2239848", P-value = 0.1593 in SZ, P-value = 0.3086 in BD and SZ; For markers "rs137931 - rs6010260 - rs138881 - rs138880", P-value = 0.11 in SZ, P-value = 0.2358 in BD and SZ; For markers "rs137932 - rs137931 - rs6010260 - rs138881", P-value = 0.4183 in SZ, P-value = 0.3061 in BD and SZ. Negative
SZ rs3810971 - rs137932; rs3810971 - rs137932 - rs137931; rs2272843 - rs3810971 - rs137932; rs3810971 - rs137932 - rs137931 - rs6010260; rs2272843 - rs3810971 - rs137932 - rs137931 For markers "rs3810971 - rs137932", P-value = 0.8971 in SZ, P-value = 0.9882 in BD and SZ; For markers "rs3810971 - rs137932 - rs137931", P-value = 0.9061 in SZ, P-value = 0.8355 in BD and SZ; For markers "rs2272843 - rs3810971 - rs137932", P-value = 0.7132 in SZ, P-value = 0.4691 in BD and SZ; For markers "rs3810971 - rs137932 - rs137931 - rs6010260", P-value = 0.1839 in SZ, P-value = 0.2924 in BD and SZ; For markers "rs2272843 - rs3810971 - rs137932 - rs137931", P-value = 0.7849 in SZ, P-value = 0.4295 in BD and SZ. Negative