Study Report

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Basic Info

Reference	Severinsen, J. E., 2006 (b) PMID: 16924267
Citation	Severinsen, J. E., C. R. Bjarkam, et al. (2006). "Evidence implicating BRD1 with brain development and susceptibility to both schizophrenia and bipolar affective disorder." Mol Psychiatry 11(12): 1126-1138.
Disease Type	Bipolar Disorder & Schizophrenia
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	103 patients with SZ, 162 patients with BPD and 200 ethnically matched controls
SNP/Region/Marker Size	16 variants
Predominant Ethnicity	Caucasian
Population	Scottish

Detail Info

Sample Diagnosis	DSM-IV
Sample Status	Diagnoses were made according to DSM-IV criteria after case-note review and personal interview using the Schedule for Affective Disorders and Schizophrenia-Lifetime version. Final diagnoses were reached by consensus between two experienced psychiatrists (DB and WM).
Technique	genotyping
Statistical Method	Chi-square and Fisher's Exact test were used to assess allele and genotype distributions. Haplotype Trend Regression (HTR) was used to estimate the frequency and analyze the distribution of haplotypes. The P-values from HTR presented in this study are empirical values based on upto 100 000 000 permutations. P-values < 0.05 are referred to as significant. The P-values presented are not corrected for multiple testing.
Result Summary	The bromodomain-containing 1 gene (BRD1), which encodes a putative regulator of transcription showed association with both disorders with minimal P-values of 0.0046 and 0.00001 for single marker and overall haplotype analysis, respectively. A specific BRD1 2-marker 'risk' haplotype showed a frequency of approximately 10% in the combined case group versus approximately 1% in controls (P-value 2.8 x 10(-7)). Expression analysis of BRD1 mRNA revealed widespread expression in mammalian brain tissue, which was substantiated by immunohistochemical detection of BRD1 protein in the nucleus, perikaryal cytosol and proximal dendrites of the neurons in the adult rat, rabbit and human CNS. Quantitative mRNA analysis in developing fetal pig brain revealed spatiotemporal differences with high expression at early embryonic stages, with intense nuclear and cytosolar immunohistochemical staining of the neuroepithelial layer and early neuroblasts, whilst more mature neurons at later embryonic stages had less nuclear staining. The results implicate BRD1 with SZ and BPD susceptibility and provide evidence that suggests a role for BRD1 in neurodevelopment.

Genetic factors reported by this study for BD

SNPs reported by this study for BD (count: 13)

SNP	Related Gene(s)	Allele Change	Statistical Values	Author Comments	Result Category
rs138855	BRD1	G/C	P-value = 0.4377 in BD, P-value = 0.4186 in BD and SZ		Negative
rs137932	MOV10L1 MLC1	G/A	P-value = 0.3229 in BD, P-value = 0.6327 in BD and SZ		Negative
rs138881	BRD1	G/A	P-value = 0.2473 in BD, P-value = 0.1727 in BD and SZ		Negative
rs138880	BRD1	A/C	P-value = 0.0274 in BD, P-value = 0.0046 in BD and SZ	Significant single-marker associations were observed for two...... Significant single-marker associations were observed for two BRD1 SNPs. More...	Positive
rs2272843	MOV10L1	C/A	P-value = 0.5064 in BD, P-value = 0.3018 in BD and SZ		Negative
rs2239848	BRD1	G/A	P-value = 0.2501 in BD, P-value = 0.3983 in BD and SZ		Negative
rs4468	BRD1	T/C	P-value = 0.7814 in BD, P-value = 0.0215 in BD and SZ	Significant single-marker associations were observed for two...... Significant single-marker associations were observed for two BRD1 SNPs in the combined group, but not with BPD. More...	Positive
rs3810971	MOV10L1	C/T	P-value = 0.5368 in BD, P-value = 0.9874 in BD and SZ		Negative
rs137931	MOV10L1 MLC1	C/-	P-value = 0.2842 in BD, P-value = 0.5796 in BD and SZ		Negative
rs132234	FAM19A5	C/T	P-value = 0.6271 in BD, P-value = 0.6116 in BD and SZ		Negative
rs916005	MAPK8IP2 CHKB	G/A	P-value = 0.8427 in BD, P-value = 1 in BD and SZ		Negative
rs6010260	MLC1	G/T	P-value = 0.4011 in BD, P-value = 0.1631 in BD and SZ		Negative
rs715519	MAPK8IP2 CHKB	C/G	P-value = 0.4675 in BD, P-value = 0.7976 in BD and SZ		Negative

Haplotypes reported by this study for BD (count: 45)

Markers	Haplotype	Related Gene(s)/Region(s)	Statistical Values	Author Comments	Result Category
rs2272843 - rs3810971 - rs137932		MOV10L1 MLC1	P-value = 0.328 in BD, P-value = 0.4691 in BD and SZ		Negative
rs2272843 - rs3810971 - rs137932 - rs137931		MOV10L1 MLC1	P-value = 0.3263 in BD, P-value = 0.4295 in BD and SZ		Negative
rs6010260 - rs138881 - rs138880 - rs2239848		MLC1 BRD1	P-value = 0.5603 in BD, P-value = 0.3086 in BD and SZ		Negative
rs2272843 - rs3810971		MOV10L1	P-value = 0.1395 in BD, P-value = 0.1966 in BD and SZ		Negative
rs6010260 - rs138881		MLC1 BRD1	P-value = 0.6883 in BD, P-value = 0.4043 in BD and SZ		Negative
rs6010260 - rs138881 - rs138880		MLC1 BRD1	P-value = 0.6108 in BD, P-value = 0.2102 in BD and SZ		Negative
rs137931 - rs6010260 - rs138881 - rs138880		MLC1 BRD1	P-value = 0.443 in BD, P-value = 0.2358 in BD and SZ		Negative
rs137932 - rs137931 - rs6010260 - rs138881		MLC1 BRD1	P-value = 0.2014 in BD, P-value = 0.3061 in BD and SZ		Negative
rs3810971 - rs137932 - rs137931 - rs6010260		MOV10L1 MLC1	P-value = 0.7716 in BD, P-value = 0.2924 in BD and SZ		Negative
D22S1169 - D22S922			P-value = 0.6196 in BD, P-value = 0.427 in BD and SZ		Negative
rs3810971 - rs137932		MOV10L1 MLC1	P-value = 0.8155 in BD, P-value = 0.9882 in BD and SZ		Negative
rs3810971 - rs137932 - rs137931		MOV10L1 MLC1	P-value = 0.8016 in BD, P-value = 0.8355 in BD and SZ		Negative
rs138855 - rs2239848 - rs138880 - rs138881	G-G-C-A	BRD1	P-value = 8E-05 in BD, P-value = 2E-05 in BD and SZ		Positive
rs138855 - rs4468		BRD1	P-value = 0.0769 in BD, P-value = 0.3182 in BD and SZ		Negative
rs138855 - rs4468 - D22S1169		BRD1	P-value = 0.5369 in BD, P-value = 0.1374 in BD and SZ		Negative
rs138855 - rs4468 - D22S1169 - D22S922		BRD1	P-value = 0.5341 in BD, P-value = 0.1149 in BD and SZ		Negative
D22S922 - D22S1169 - rs4468	2-3-C	BRD1	P-value = 0.0248 in BD and SZ		Positive
rs138855 - rs138880	G-C	BRD1	P-value = 1.6E-06 in BD, P-value = 2.8E-07 in BD and SZ	Removing the rare middle SNP rs2239848 from the analysis res...... Removing the rare middle SNP rs2239848 from the analysis resulted in a reduced 2-marker 'risk' haplotype (G-C) showing a frequency of ~10% in cases versus ~1% in controls. More...	Positive
rs138855 - rs138880 - rs138881	G-C-A	BRD1	P-value = 1E-04 in BD, P-value = 4E-05 in BD and SZ		Positive
rs138855 - rs138880 - rs138881	G-C-G	BRD1	P-value = 0.0018 in BD, P-value = 0.0022 in BD and SZ		Positive
rs138855 - rs2239848 - rs138880	G-G-C	BRD1	P-value = 3E-06 in BD, P-value = 1E-06 in BD and SZ	A 3-marker core haplotype spanning BRD1 SNPs rs138855, rs223...... A 3-marker core haplotype spanning BRD1 SNPs rs138855, rs2239848 and rs138880 had a frequency of around 9% in cases against only 1% in controls, producing a haplotype specific P-value of order 1E-06. More...	Positive
rs138881 - rs138880 - rs2239848		BRD1	P-value = 0.2096 in BD, P-value = 0.155 in BD and SZ		Negative
rs138881 - rs138880 - rs2239848 - rs138855		BRD1	P-value = 0.0013 in BD, P-value = 0.0003 in BD and SZ	Highly significant overall P-values (as low as 0.00001) were...... Highly significant overall P-values (as low as 0.00001) were observed in especially the 3- and 4-marker analysis involving the BRD1 SNPs rs138855, rs2239848, rs138880 and rs138881. More...	Positive
rs2239848 - rs138855		BRD1	P-value = 0.5005 in BD, P-value = 0.6658 in BD and SZ		Negative
rs2239848 - rs138855 - rs4468		BRD1	P-value = 0.1742 in BD, P-value = 0.2092 in BD and SZ		Negative
rs138880 - rs2239848		BRD1	P-value = 0.0797 in BD, P-value = 0.0381 in BD and SZ		Positive
rs138880 - rs2239848 - rs138855		BRD1	P-value = 0.00006 in BD, P-value = 0.00005 in BD and SZ	Highly significant overall P-values (as low as 0.00001) were...... Highly significant overall P-values (as low as 0.00001) were observed in especially the 3- and 4-marker analysis involving the BRD1 SNPs rs138855, rs2239848, rs138880 and rs138881. More...	Positive
rs138880 - rs2239848 - rs138855 - rs4468		BRD1	P-value = 0.1877 in BD, P-value = 0.0607 in BD and SZ		Negative
rs138881 - rs138880		BRD1	P-value = 0.1822 in BD, P-value = 0.0681 in BD and SZ		Negative
D22S922 - rs132234		FAM19A5	P-value = 0.892 in BD, P-value = 0.5738 in BD and SZ		Negative
D22S1169 - D22S922 - rs132234		FAM19A5	P-value = 0.4032 in BD, P-value = 0.4635 in BD and SZ		Negative
rs715519 - rs2272843		MAPK8IP2 MOV10L1	P-value = 0.6392 in BD, P-value = 0.7516 in BD and SZ		Negative
rs916005 - rs715519		MAPK8IP2	P-value = 0.8895 in BD, P-value = 0.9552 in BD and SZ		Negative
rs4468 - D22S1169		BRD1	P-value = 0.8945 in BD, P-value = 0.3317 in BD and SZ		Negative
rs2239848 - rs138855 - rs4468 - D22S1169		BRD1	P-value = 0.5517 in BD, P-value = 0.263 in BD and SZ		Negative
rs4468 - D22S1169 - D22S922 - rs132234		BRD1 FAM19A5	P-value = 0.7872 in BD, P-value = 0.1853 in BD and SZ		Negative
rs4468 - D22S1169 - D22S922		BRD1	P-value = 0.8753 in BD, P-value = 0.403 in BD and SZ		Negative
rs137932 - rs137931		MLC1	P-value = 0.8343 in BD, P-value = 0.921 in BD and SZ		Negative
rs137931 - rs6010260		MLC1	P-value = 0.2795 in BD, P-value = 0.1604 in BD and SZ		Negative
rs137931 - rs6010260 - rs138881		MLC1 BRD1	P-value = 0.1011 in BD, P-value = 0.1926 in BD and SZ		Negative
rs137932 - rs137931 - rs6010260		MLC1	P-value = 0.3976 in BD, P-value = 0.4051 in BD and SZ		Negative
rs715519 - rs2272843 - rs3810971 - rs137932		MAPK8IP2 MOV10L1	P-value = 0.4475 in BD, P-value = 0.4123 in BD and SZ		Negative
rs715519 - rs2272843 - rs3810971		MAPK8IP2 MOV10L1	P-value = 0.3063 in BD, P-value = 0.4568 in BD and SZ		Negative
rs916005 - rs715519 - rs2272843 - rs3810971		MAPK8IP2 MOV10L1	P-value = 0.3167 in BD, P-value = 0.7152 in BD and SZ		Negative
rs916005 - rs715519 - rs2272843		MAPK8IP2 MOV10L1	P-value = 0.8328 in BD, P-value = 0.9786 in BD and SZ		Negative

Other variants reported by this study for BD (count: 2)

Variant Name	Related Gene	Type	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
D22S1169		microsatellite			P-value = 0.4042 in BD, P-value = 0.0383 in BD and SZ	Significant single-marker association was observed for D22S1...... Significant single-marker association was observed for D22S1169 in the combined group, but not with BPD. More...	Positive
D22S922		microsatellite			P-value = 0.0885 in BD, P-value = 0.5552 in BD and SZ		Negative

Genes reported by this study for BD (count: 4)

Gene	Statistical Values/Author Comments	Result Category
MOV10L1	The results do not support an association of the gene with BD. The results do not support an association of the gene with BD.	Negative
MAPK8IP2	The results do not support an association of the gene with BD. The results do not support an association of the gene with BD.	Negative
MLC1	The results do not support an association of the gene with BD. The results do not support an association of the gene with BD.	Negative
BRD1	The results implicate BRD1 with SZ and BPD susceptibility and provide evidence that suggests a role ...... The results implicate BRD1 with SZ and BPD susceptibility and provide evidence that suggests a role for BRD1 in neurodevelopment. More...	Positive

Gene-gene interactions reported by this study for BD (count: 4)

Gene Group	Markers	Statistical Values	Result Category
BRD1 FAM19A5	rs4468 - D22S1169 - D22S922 - rs132234	P-value = 0.7872 in BD, P-value = 0.1853 in BD and SZ	Negative
MAPK8IP2 MOV10L1	rs715519 - rs2272843; rs715519 - rs2272843 - rs3810971; rs916005 - rs715519 - rs2272843; rs715519 - rs2272843 - rs3810971 - rs137932; rs916005 - rs715519 - rs2272843 - rs3810971	For markers "rs715519 - rs2272843", P-value = 0.6392 in BD, P-value = 0.7516 in BD and SZ; For markers "rs715519 - rs2272843 - rs3810971", P-value = 0.3063 in BD, P-value = 0.4568 in BD and SZ; For markers "rs916005 - rs715519 - rs2272843", P-value = 0.8328 in BD, P-value = 0.9786 in BD and SZ; For markers "rs715519 - rs2272843 - rs3810971 - rs137932", P-value = 0.4475 in BD, P-value = 0.4123 in BD and SZ; For markers "rs916005 - rs715519 - rs2272843 - rs3810971", P-value = 0.3167 in BD, P-value = 0.7152 in BD and SZ.	Negative
MLC1 BRD1	rs6010260 - rs138881; rs6010260 - rs138881 - rs138880; rs137931 - rs6010260 - rs138881; rs6010260 - rs138881 - rs138880 - rs2239848; rs137931 - rs6010260 - rs138881 - rs138880; rs137932 - rs137931 - rs6010260 - rs138881	For markers "rs6010260 - rs138881", P-value = 0.6883 in BD, P-value = 0.4043 in BD and SZ; For markers "rs6010260 - rs138881 - rs138880", P-value = 0.6108 in BD, P-value = 0.2102 in BD and SZ; For markers "rs137931 - rs6010260 - rs138881", P-value = 0.1011 in BD, P-value = 0.1926 in BD and SZ; For markers "rs6010260 - rs138881 - rs138880 - rs2239848", P-value = 0.5603 in BD, P-value = 0.3086 in BD and SZ; For markers "rs137931 - rs6010260 - rs138881 - rs138880", P-value = 0.443 in BD, P-value = 0.2358 in BD and SZ; For markers "rs137932 - rs137931 - rs6010260 - rs138881", P-value = 0.2014 in BD, P-value = 0.3061 in BD and SZ.	Negative
MOV10L1 MLC1	rs3810971 - rs137932; rs3810971 - rs137932 - rs137931; rs2272843 - rs3810971 - rs137932; rs3810971 - rs137932 - rs137931 - rs6010260; rs2272843 - rs3810971 - rs137932 - rs137931	For markers "rs3810971 - rs137932", P-value = 0.8155 in BD, P-value = 0.9882 in BD and SZ; For markers "rs3810971 - rs137932 - rs137931", P-value = 0.8016 in BD, P-value = 0.8355 in BD and SZ; For markers "rs2272843 - rs3810971 - rs137932", P-value = 0.328 in BD, P-value = 0.4691 in BD and SZ; For markers "rs3810971 - rs137932 - rs137931 - rs6010260", P-value = 0.7716 in BD, P-value = 0.2924 in BD and SZ; For markers "rs2272843 - rs3810971 - rs137932 - rs137931", P-value = 0.3263 in BD, P-value = 0.4295 in BD and SZ.	Negative

Genetic factors reported by this study for SZ and/or MDD

SNPs reported by this study for SZ/MDD

Disease	SNP	Related Gene(s)	Statistical Values	Description	Result Category
SZ	rs916005	MAPK8IP2 CHKB	P-value = 0.8482 in SZ, P-value = 1 in BD and SZ		Negative
SZ	rs4468	BRD1	P-value = 0.0088 in SZ, P-value = 0.0215 in BD and SZ	SNP rs4468 and D22S1169 showed significant association with SZ but not with BPD.	Positive
SZ	rs3810971	MOV10L1	P-value = 0.3431 in SZ, P-value = 0.9874 in BD and SZ		Negative
SZ	rs715519	MAPK8IP2 CHKB	P-value = 0.7254 in SZ, P-value = 0.7976 in BD and SZ		Negative
SZ	rs6010260	MLC1	P-value = 0.0823 in SZ, P-value = 0.1631 in BD and SZ		Negative
SZ	rs138880	BRD1	P-value = 0.0061 in SZ, P-value = 0.0046 in BD and SZ	The promoter SNP rs138880 showed association in SZ and the combined case group.	Positive
SZ	rs138881	BRD1	P-value = 0.2896 in SZ, P-value = 0.1727 in BD and SZ		Negative
SZ	rs2239848	BRD1	P-value = 1 in SZ, P-value = 0.3983 in BD and SZ		Negative
SZ	rs2272843	MOV10L1	P-value = 0.2701 in SZ, P-value = 0.3018 in BD and SZ		Negative
SZ	rs132234	FAM19A5	P-value = 0.7013 in SZ, P-value = 0.6116 in BD and SZ		Negative
SZ	rs137931	MOV10L1 MLC1	P-value = 0.844 in SZ, P-value = 0.5796 in BD and SZ		Negative
SZ	rs137932	MOV10L1 MLC1	P-value = 0.7615 in SZ, P-value = 0.6327 in BD and SZ		Negative
SZ	rs138855	BRD1	P-value = 0.501 in SZ, P-value = 0.4186 in BD and SZ		Negative

Haplotypes reported by this study for SZ/MDD

Disease	Markers	Haplotype	Related Gene(s)/Region(s)	Statistical Values	Description	Result Category
SZ	rs138880 - rs2239848 - rs138855 - rs4468		BRD1	P-value = 0.0203 in SZ, P-value = 0.0607 in BD and SZ		Positive
SZ	rs138880 - rs2239848 - rs138855		BRD1	P-value = 0.00001 in SZ, P-value = 0.00005 in BD and SZ	Highly significant overall P-values (as low as 0.00001) were observed in especially the 3- and 4-marker analysis involving the BRD1 SNPs rs138855, rs2239848, rs138880 and rs138881.	Positive
SZ	rs138881 - rs138880 - rs2239848		BRD1	P-value = 0.1358 in SZ, P-value = 0.155 in BD and SZ		Negative
SZ	rs138881 - rs138880		BRD1	P-value = 0.0521 in SZ, P-value = 0.0681 in BD and SZ		Negative
SZ	rs138855 - rs4468 - D22S1169		BRD1	P-value = 0.0117 in SZ, P-value = 0.1374 in BD and SZ		Negative
SZ	rs138855 - rs4468		BRD1	P-value = 0.1138 in SZ, P-value = 0.3182 in BD and SZ		Negative
SZ	rs138880 - rs2239848		BRD1	P-value = 0.161 in SZ, P-value = 0.0381 in BD and SZ		Positive
SZ	rs138855 - rs4468 - D22S1169 - D22S922		BRD1	P-value = 0.0839 in SZ, P-value = 0.1149 in BD and SZ		Negative
SZ	rs138855 - rs138880 - rs138881	G-C-G	BRD1	P-value = 0.0015 in BD, P-value = 0.0022 in BD and SZ		Positive
SZ	rs138855 - rs138880 - rs138881	G-C-A	BRD1	P-value = 2E-04 in BD, P-value = 4E-05 in BD and SZ		Positive
SZ	rs138855 - rs2239848 - rs138880 - rs138881	G-G-C-A	BRD1	P-value = 2E-04 in BD, P-value = 2E-05 in BD and SZ		Positive
SZ	rs138855 - rs2239848 - rs138880	G-G-C	BRD1	P-value = 4E-06 in BD, P-value = 1E-06 in BD and SZ	A 3-marker core haplotype spanning BRD1 SNPs rs138855, rs2239848 and rs138880 had a frequency of around 9% in cases against only 1% in controls, producing a haplotype specific P-value of order 1E-06.	Positive
SZ	rs138855 - rs138880	G-C	BRD1	P-value = 1E-06 in BD, P-value = 2.8E-07 in BD and SZ	Removing the rare middle SNP rs2239848 from the analysis resulted in a reduced 2-marker 'risk' haplotype (G-C) showing a frequency of ~10% in cases versus ~1% in controls.	Positive
SZ	D22S922 - D22S1169 - rs4468	2-3-C	BRD1	P-value = 0.0120 in BD and SZ		Positive
SZ	rs715519 - rs2272843 - rs3810971 - rs137932		MAPK8IP2 MOV10L1	P-value = 0.5239 in SZ, P-value = 0.4123 in BD and SZ		Negative
SZ	rs916005 - rs715519 - rs2272843		MAPK8IP2 MOV10L1	P-value = 0.9187 in SZ, P-value = 0.9786 in BD and SZ		Negative
SZ	rs916005 - rs715519 - rs2272843 - rs3810971		MAPK8IP2 MOV10L1	P-value = 0.7463 in SZ, P-value = 0.7152 in BD and SZ		Negative
SZ	rs137931 - rs6010260		MLC1	P-value = 0.1836 in SZ, P-value = 0.1604 in BD and SZ		Negative
SZ	D22S922 - rs132234		FAM19A5	P-value = 0.595 in SZ, P-value = 0.5738 in BD and SZ		Negative
SZ	rs916005 - rs715519		MAPK8IP2	P-value = 0.9765 in SZ, P-value = 0.9552 in BD and SZ		Negative
SZ	rs715519 - rs2272843		MAPK8IP2 MOV10L1	P-value = 0.6423 in SZ, P-value = 0.7516 in BD and SZ		Negative
SZ	rs715519 - rs2272843 - rs3810971		MAPK8IP2 MOV10L1	P-value = 0.5626 in SZ, P-value = 0.4568 in BD and SZ		Negative
SZ	rs4468 - D22S1169		BRD1	P-value = 0.0184 in SZ, P-value = 0.3317 in BD and SZ		Positive
SZ	rs4468 - D22S1169 - D22S922		BRD1	P-value = 0.0657 in SZ, P-value = 0.403 in BD and SZ		Negative
SZ	rs4468 - D22S1169 - D22S922 - rs132234		BRD1 FAM19A5	P-value = 0.0228 in SZ, P-value = 0.1853 in BD and SZ		Positive
SZ	D22S1169 - D22S922 - rs132234		FAM19A5	P-value = 0.0426 in SZ, P-value = 0.4635 in BD and SZ		Positive
SZ	rs138881 - rs138880 - rs2239848 - rs138855		BRD1	P-value = 0.0002 in SZ, P-value = 0.0003 in BD and SZ	Highly significant overall P-values (as low as 0.00001) were observed in especially the 3- and 4-marker analysis involving the BRD1 SNPs rs138855, rs2239848, rs138880 and rs138881.	Positive
SZ	rs2239848 - rs138855		BRD1	P-value = 0.5944 in SZ, P-value = 0.6658 in BD and SZ		Negative
SZ	rs2239848 - rs138855 - rs4468		BRD1	P-value = 0.047 in SZ, P-value = 0.2092 in BD and SZ		Positive
SZ	rs2239848 - rs138855 - rs4468 - D22S1169		BRD1	P-value = 0.0095 in SZ, P-value = 0.263 in BD and SZ		Positive
SZ	D22S1169 - D22S922			P-value = 0.0194 in SZ, P-value = 0.427 in BD and SZ		Positive
SZ	rs3810971 - rs137932 - rs137931 - rs6010260		MOV10L1 MLC1	P-value = 0.1839 in SZ, P-value = 0.2924 in BD and SZ		Negative
SZ	rs3810971 - rs137932 - rs137931		MOV10L1 MLC1	P-value = 0.9061 in SZ, P-value = 0.8355 in BD and SZ		Negative
SZ	rs3810971 - rs137932		MOV10L1 MLC1	P-value = 0.8971 in SZ, P-value = 0.9882 in BD and SZ		Negative
SZ	rs2272843 - rs3810971 - rs137932 - rs137931		MOV10L1 MLC1	P-value = 0.7849 in SZ, P-value = 0.4295 in BD and SZ		Negative
SZ	rs2272843 - rs3810971 - rs137932		MOV10L1 MLC1	P-value = 0.7132 in SZ, P-value = 0.4691 in BD and SZ		Negative
SZ	rs2272843 - rs3810971		MOV10L1	P-value = 0.3417 in SZ, P-value = 0.1966 in BD and SZ		Negative
SZ	rs6010260 - rs138881 - rs138880 - rs2239848		MLC1 BRD1	P-value = 0.1593 in SZ, P-value = 0.3086 in BD and SZ		Negative
SZ	rs6010260 - rs138881 - rs138880		MLC1 BRD1	P-value = 0.0763 in SZ, P-value = 0.2102 in BD and SZ		Negative
SZ	rs6010260 - rs138881		MLC1 BRD1	P-value = 0.3103 in SZ, P-value = 0.4043 in BD and SZ		Negative
SZ	rs137932 - rs137931 - rs6010260 - rs138881		MLC1 BRD1	P-value = 0.4183 in SZ, P-value = 0.3061 in BD and SZ		Negative
SZ	rs137931 - rs6010260 - rs138881 - rs138880		MLC1 BRD1	P-value = 0.11 in SZ, P-value = 0.2358 in BD and SZ		Negative
SZ	rs137931 - rs6010260 - rs138881		MLC1 BRD1	P-value = 0.3326 in SZ, P-value = 0.1926 in BD and SZ		Negative
SZ	rs137932 - rs137931 - rs6010260		MLC1	P-value = 0.2821 in SZ, P-value = 0.4051 in BD and SZ		Negative
SZ	rs137932 - rs137931		MLC1	P-value = 0.8969 in SZ, P-value = 0.921 in BD and SZ		Negative

Other variants reported by this study for SZ/MDD

Disease	Variant Name	Related Gene	Type	Statistical Values	Description	Result Category
SZ	D22S1169		microsatellite	P-value = 0.0214 in SZ, P-value = 0.0383 in BD and SZ	SNP rs4468 and D22S1169 showed significant association with SZ.	Positive
SZ	D22S922		microsatellite	P-value = 0.3501 in SZ, P-value = 0.5552 in BD and SZ		Negative

Genes reported by this study for SZ/MDD

Disease	Gene	Description	Result Category
SZ	MLC1	The results do not support an association of the gene with SZ.	Negative
SZ	MOV10L1	The results do not support an association of the gene with SZ.	Negative
SZ	MAPK8IP2	The results do not support an association of the gene with SZ.	Negative
SZ	BRD1	The results implicate BRD1 with SZ and BPD susceptibility and provide evidence that suggests a role for BRD1 in neurodevelopment.	Positive

Gene-gene interactions reported by this study for SZ/MDD

Disease	Markers	Statistical Values	Result Category
SZ	rs4468 - D22S1169 - D22S922 - rs132234	P-value = 0.0228 in SZ, P-value = 0.1853 in BD and SZ	Positive
SZ	rs715519 - rs2272843; rs715519 - rs2272843 - rs3810971; rs916005 - rs715519 - rs2272843; rs715519 - rs2272843 - rs3810971 - rs137932; rs916005 - rs715519 - rs2272843 - rs3810971	For markers "rs715519 - rs2272843", P-value = 0.6423 in SZ, P-value = 0.7516 in BD and SZ; For markers "rs715519 - rs2272843 - rs3810971", P-value = 0.5626 in SZ, P-value = 0.4568 in BD and SZ; For markers "rs916005 - rs715519 - rs2272843", P-value = 0.9187 in SZ, P-value = 0.9786 in BD and SZ; For markers "rs715519 - rs2272843 - rs3810971 - rs137932", P-value = 0.5239 in SZ, P-value = 0.4123 in BD and SZ; For markers "rs916005 - rs715519 - rs2272843 - rs3810971", P-value = 0.7463 in SZ, P-value = 0.7152 in BD and SZ.	Negative
SZ	rs6010260 - rs138881; rs6010260 - rs138881 - rs138880; rs137931 - rs6010260 - rs138881; rs6010260 - rs138881 - rs138880 - rs2239848; rs137931 - rs6010260 - rs138881 - rs138880; rs137932 - rs137931 - rs6010260 - rs138881	For markers "rs6010260 - rs138881", P-value = 0.3103 in SZ, P-value = 0.4043 in BD and SZ; For markers "rs6010260 - rs138881 - rs138880", P-value = 0.0763 in SZ, P-value = 0.2102 in BD and SZ; For markers "rs137931 - rs6010260 - rs138881", P-value = 0.3326 in SZ, P-value = 0.1926 in BD and SZ; For markers "rs6010260 - rs138881 - rs138880 - rs2239848", P-value = 0.1593 in SZ, P-value = 0.3086 in BD and SZ; For markers "rs137931 - rs6010260 - rs138881 - rs138880", P-value = 0.11 in SZ, P-value = 0.2358 in BD and SZ; For markers "rs137932 - rs137931 - rs6010260 - rs138881", P-value = 0.4183 in SZ, P-value = 0.3061 in BD and SZ.	Negative
SZ	rs3810971 - rs137932; rs3810971 - rs137932 - rs137931; rs2272843 - rs3810971 - rs137932; rs3810971 - rs137932 - rs137931 - rs6010260; rs2272843 - rs3810971 - rs137932 - rs137931	For markers "rs3810971 - rs137932", P-value = 0.8971 in SZ, P-value = 0.9882 in BD and SZ; For markers "rs3810971 - rs137932 - rs137931", P-value = 0.9061 in SZ, P-value = 0.8355 in BD and SZ; For markers "rs2272843 - rs3810971 - rs137932", P-value = 0.7132 in SZ, P-value = 0.4691 in BD and SZ; For markers "rs3810971 - rs137932 - rs137931 - rs6010260", P-value = 0.1839 in SZ, P-value = 0.2924 in BD and SZ; For markers "rs2272843 - rs3810971 - rs137932 - rs137931", P-value = 0.7849 in SZ, P-value = 0.4295 in BD and SZ.	Negative