Gene Report

Basic Info
Approved Symbol PPP1R1B
Symbol Alias DARPP-32, FLJ20940
Approved Name protein phosphatase 1, regulatory (inhibitor) subunit 1B
Name Alias dopamine and cAMP regulated phosphoprotein
Location 17q12
Position chr17:39626740-39636626, 1
External Links HGNC: 9287
Entrez Gene: 84152
Ensembl: ENSG00000131771
UCSC: uc002hrz.3
No. of Studies 1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Yoshimi, A., 2008 SNP: rs12601930, rs3764352, rs879606, rs907094
Haplotype: rs2271309 - rs12601930 - rs907094 - rs3764352()
Single-marker and haplotypic analyses of four single nucleotide polymorphisms (SNPs; rs879606, rs12601930, rs907094, and rs3764352) in a sample set (subjects with schizophrenia=384, subjects with bipolar disorder=318, control subjects=384) showed that even after Bonferroni corrections, significant associations with bipolar disorder were observed for rs12601930 (corrected genotypic p=0.00059) and rs907094 (corrected allelic p=0.040). We, however, could not confirm these results in a second independent sample set (subjects with bipolar disorder=366, control subjects=370).. Our findings suggest that PPP1R1B SNPs are unlikely to be related to the development of schizophrenia and bipolar disorder in the Japanese population. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 23)

GO terms by PBA (count: 1)

GO terms by database search (count: 22)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 2)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 2)

Gene related interactors from protein-protein interactions data in HPRD (count: 7)

Related other genetic factors
Gene related SNPs (count: 6)

Literature-origin SNPs (count: 4)

LD-proxies (count: 2)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 6)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 7)

Gene relationship with MDD

View in gBrowse

Region: chr17:39626740..39636626 View in gBrowse
View in gBrowse