SNP Report

Basic Info

Name	rs1344706 dbSNP Ensembl
Location	chr2:184913701 - 184913701(1)
Variant Alleles	A/C
Ancestral Allele	A
Minor Allele	C
Minor Allele Frequence	0.304513
Functional Annotation	intron_variant.
Consequence to Transcript	intron_variant(ENST00000302277, ENST00000613975)
No. of Studies	5 (Positive: 3; Negative: 2; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	NO

SNP related studies (count: 5)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Zhang, C., 2015	T/G		allelic P-value=0.034, OR (95 % CI)=1.19 (1.03-1.37); genoty...... allelic P-value=0.034, OR (95 % CI)=1.19 (1.03-1.37); genotypic P-value=0.08; meta-analysis, P-value=0.24, X²=4.24, df=3, I²=29%, test for overall effect: Z=3.64, P-value=0.0003; allelic P-value=0.014, OR (95 % CI)=1.30 (1.07-1.56), genotypic P-value=0.04 between BD-I and control groups; allelic P-value=0.34, OR (95 % CI)=1.12 (0.95-1.33), genotypic P-value=0.52 between BD-II and control groups More...	The rs1344706 showed significant allelic association with BD...... The rs1344706 showed significant allelic association with BD. The frequency of T allele of rs1344706 was higher in patients than that in controls. After pooling all data, meta-analysis indicated a significant association of rs1344706 with BD. After stratified by diagnosis, the association of rs1344706 with BD was only survived in BD-I, but not in BD-II. More...	Positive
Schanze, D.,2011		T	X² tests: allele P-value = 0.82 for BP. X² tests: allele P-value = 0.82 for BP.	No significant association was observed in BD. No significant association was observed in BD.	Negative
Guella, I., 2013	C/A		P-value=0.630, X²=0.23 P-value=0.630, X²=0.23	No significant association between rs1344706 and SZ or BD wa...... No significant association between rs1344706 and SZ or BD was observed using DFAM. More...	Negative
Sun, Y., 2015			P-value=0.2, I²=38%, chi-square=3.24, df=2; test ...... P-value=0.2, I²=38%, chi-square=3.24, df=2; test for overall effect: P-value=0.003, Z=2.93 More...	We also found a significant association betweenthe T-allele ...... We also found a significant association betweenthe T-allele of rs1344706 and bipolar disorder in the fixed-effect analysis. More...	Positive
Lett, T. A.,2011	C/A	A	FBAT: P-value = 0.046 FBAT: P-value = 0.046	Significant association was found in BD. Significant association was found in BD.	Positive

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
ZNF804A	zinc finger protein 804A	2q32.1	6(3/3/0)

SNPs in LD with rs1344706 (count: 0) View in gBrowse (chr2:184913701..184913701 )

Overlap with SZ from cross-disorder studies (count: 3)

Reference	Statistical Result	Description	Result Category
Sun, Y., 2015	P-value<0.00001, I²=71%, chi-square=100.88 df=29, Heterrogeneity Tau²=0.01	In the subgroup analysis of diseases, we found a significant associationbetween the T-allele of rs1344706 and schizophrenia in the random effect meta-analysis	Positive
Schanze, D.,2011	X² tests:allele P-value = 0.31 for SCZ.	No significant association was observed.	Negative
Guella, I., 2013	P-value=0.402, X²=0.70	No significant association between rs1344706 and SZ or BD was observed using DFAM.	Negative

Overlap with MDD from cross-disorder studies (count: 0)