BDgene

SNP Report

Basic Info
Name rs1344706 dbSNP Ensembl
Location chr2:184913701 - 184913701(1)
Variant Alleles A/C
Ancestral Allele A
Minor Allele C
Minor Allele Frequence 0.304513
Functional Annotation intron_variant.
Consequence to Transcript intron_variant(ENST00000302277, ENST00000613975)
No. of Studies 5 (Positive: 3; Negative: 2; Trend: 0)
Source Literature
Overlap with SZ? YES
Overlap with MDD? NO

SNP related studies (count: 5)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Zhang, C., 2015 T/G allelic P-value=0.034, OR (95 % CI)=1.19 (1.03-1.37); genoty...... allelic P-value=0.034, OR (95 % CI)=1.19 (1.03-1.37); genotypic P-value=0.08; meta-analysis, P-value=0.24, X2=4.24, df=3, I2=29%, test for overall effect: Z=3.64, P-value=0.0003; allelic P-value=0.014, OR (95 % CI)=1.30 (1.07-1.56), genotypic P-value=0.04 between BD-I and control groups; allelic P-value=0.34, OR (95 % CI)=1.12 (0.95-1.33), genotypic P-value=0.52 between BD-II and control groups More... The rs1344706 showed significant allelic association with BD...... The rs1344706 showed significant allelic association with BD. The frequency of T allele of rs1344706 was higher in patients than that in controls. After pooling all data, meta-analysis indicated a significant association of rs1344706 with BD. After stratified by diagnosis, the association of rs1344706 with BD was only survived in BD-I, but not in BD-II. More... Positive
Schanze, D.,2011 T X2 tests: allele P-value = 0.82 for BP. X2 tests: allele P-value = 0.82 for BP. No significant association was observed in BD. No significant association was observed in BD. Negative
Guella, I., 2013 C/A P-value=0.630, X2=0.23 P-value=0.630, X2=0.23 No significant association between rs1344706 and SZ or BD wa...... No significant association between rs1344706 and SZ or BD was observed using DFAM. More... Negative
Sun, Y., 2015 P-value=0.2, I2=38%, chi-square=3.24, df=2; test ...... P-value=0.2, I2=38%, chi-square=3.24, df=2; test for overall effect: P-value=0.003, Z=2.93 More... We also found a significant association betweenthe T-allele ...... We also found a significant association betweenthe T-allele of rs1344706 and bipolar disorder in the fixed-effect analysis. More... Positive
Lett, T. A.,2011 C/A A FBAT: P-value = 0.046 FBAT: P-value = 0.046 Significant association was found in BD. Significant association was found in BD. Positive

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
ZNF804A zinc finger protein 804A 2q32.1 6(3/3/0)

SNPs in LD with rs1344706 (count: 0) View in gBrowse (chr2:184913701..184913701 )

Overlap with SZ from cross-disorder studies (count: 3)
Reference Statistical Result Description Result Category
Sun, Y., 2015 P-value<0.00001, I2=71%, chi-square=100.88 df=29, Heterrogeneity Tau2=0.01 In the subgroup analysis of diseases, we found a significant associationbetween the T-allele of rs1344706 and schizophrenia in the random effect meta-analysis Positive
Schanze, D.,2011 X2 tests:allele P-value = 0.31 for SCZ. No significant association was observed. Negative
Guella, I., 2013 P-value=0.402, X2=0.70 No significant association between rs1344706 and SZ or BD was observed using DFAM. Negative

Overlap with MDD from cross-disorder studies (count: 0)