SNP Report

Basic Info

Name	rs327329 dbSNP Ensembl
Location	chr8:31995982 - 31995982(1)
Variant Alleles	C/T
Ancestral Allele	T
Minor Allele	C
Minor Allele Frequence	0.297923
Functional Annotation	intron_variant.
Consequence to Transcript	intron_variant(ENST00000518104, ENST00000519301, ENST00000520407, ENST00000523534)
No. of Studies	2 (Positive: 0; Negative: 2; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	NO

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Thomson, P. A., 2007			Individual P-value = 0.8399 for BP, Individual P-value = 0.7...... Individual P-value = 0.8399 for BP, Individual P-value = 0.7353 for SCZ and BP More...		Negative
Walker, R. M.,2010			X² test: P-value = 0.85 for Scottish 1, P-value =...... X² test: P-value = 0.85 for Scottish 1, P-value = 0.58 for Scottish 2, P-value = 0.85 for merged Scottish More...	No significant association was observed in BD. No significant association was observed in BD.	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
NRG1	neuregulin 1	8p12	15(10/5/0)

SNPs in LD with rs327329 (count: 17) View in gBrowse (chr8:31989556..32086512 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Functional Annotation	r²[population]
rs6983358	intron_variant	0.81[CEU]
rs16878670	intron_variant; upstream_gene_variant	0.847[CEU]
rs327341	intron_variant	0.848[CEU]
rs9297185	intron_variant; non_coding_transcript_variant	0.853[CEU]
rs7835626	intron_variant	0.81[CEU]
rs2929484	intron_variant	0.853[CEU]; 0.939[TSI]
rs1462900	intron_variant; non_coding_transcript_variant	0.899[CEU]
rs1947734	intron_variant; non_coding_transcript_variant	0.852[CEU]
rs4147431	intron_variant	0.81[CEU]
rs1947735	intron_variant; upstream_gene_variant	0.853[CEU]
rs11782798	intron_variant	0.81[CEU]
rs10954818	intron_variant	0.853[CEU]
rs16878780	intron_variant; non_coding_transcript_variant	0.899[CEU]
rs1381871	intron_variant; non_coding_transcript_variant	0.899[CEU]
rs7818326	intron_variant; non_coding_transcript_variant	0.852[CEU]
rs327338	intron_variant	0.871[CEU]
rs2881470	intron_variant; non_coding_transcript_variant	0.899[CEU]

Overlap with SZ from cross-disorder studies (count: 2)

Reference	Statistical Result	Description	Result Category
Walker, R. M.,2010	X² test:P-value = 0.44 for Scottish 1, P-value = 0.99 for Scottish 2, P-value = 0.56 for merged Scottish	No significant association was observed.	Negative
Thomson, P. A., 2007	Individual P-value = 0.4418 for SCZ , Individual P-value = 0.7353 for SCZ and BP		Negative

Overlap with MDD from cross-disorder studies (count: 0)