Study Report

Reference	Joo, E. J.,2010 PMID: 20927308
Citation	Joo, E. J., K. Y. Lee, et al. (2010). "Genetic Association Study of the Alpha 7 Nicotinic Receptor (CHRNA7) with the Development of Schizophrenia and Bipolar Disorder in Korean Population." Psychiatry Investig 7(3): 196-201.
Disease Type	Bipolar Disorder & Schizophrenia
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	254 patients with schizophrenia, 193 patients with bipolar disorder type I, 38 patients with bipolar disorder type II, 64 schizoaffective disorder patients, and 349 controls
SNP/Region/Marker Size	3 SNPs
Predominant Ethnicity	Mongloid
Population	Korean
Gender	Male/female:152/102 for SZ patients,82/111 for BPI patients,17/21 for BPII patients,28/36 for SA patients and 174/175 for controls.
Age Group	Adults : Mean age(SD)(year):35.56(8.21) for SZ patients,36.79(12.55) for BPI patients,36.08(8.71) for BPII patients,31.94(11.59) for SA patients and 25.92(6.57) for controls.

Sample Diagnosis	DSM
Sample Status	Patients were recruited from the Seoul National University Hospital and several psychiatric clinics in Korea. All patients satisfied the diagnostic criteria of DSM-IV for schizophrenia and bipolar disorder. They were individually interviewed by trained nurses using the Korean version of Diagnostic Interview for Genetic Studies.Subjects with a history of any kind of organic abnormality of the brain, substance dependence, drug abuse, or other physical conditions possibly manifesting psychiatric symptoms were excluded from this study. The final analyses were performed with 549 patients and 349 controls. The patient group consisted of 254 patients with schizophrenia, 193 patients with bipolar disorder type I, 38 patients with bipolar disorder type II, and 64 patients with schizoaffective disorder. Healthy controls were free from present, past and family history (first-degree relatives) of psychiatric illness or substance abuse diagnoses.
Technique	genotyping
Statistical Method	Contingency chi-squared tests were performed for the comparison of allele and genotype frequencies between the patients and controls using Statistical Package for the Social Sciences (SPSS)(version 13.0; SPSS Inc., Chicago, IL, USA). The haplotype analyses were done using UNPHASED 3.0.13 (http://www.mrc-bsu.cam.ac.uk/personal/frank/software/unphased/).11 The haplotype association was tested for two to three SNPs with the sliding window method.
Result Summary	Resulting sequence were analyzed in a large sample of bipolar patients (n = 218) and control subjects (n = 218). No evidence was found for the involvement of variants within the CUX2 coding, or 5' UTR sequence in producing susceptibility to bipolar disorder.