Gene Report

Basic Info
Approved Symbol NGF
Previous Symbol NGFB
Approved Name nerve growth factor (beta polypeptide)
Location 1p13.1
Position chr1:115285918-115338236, -1
External Links HGNC: 7808
Entrez Gene: 4803
Ensembl: ENSG00000134259
UCSC: uc001efu.1
No. of Studies 2 (Positive: 1; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Sklar, P.,2011 SNP: rs10776799 No significant association was observed. Negative Comment on Study
Ament, S. A., 2015 Coding P-value=0.74, q-value=0.88, Regulatory P-value=0.0084, q-value=0.036. The gene has significant rare variant associations to BD. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 59)

GO terms by PBA (count: 1)

GO terms by database search (count: 58)

Gene related KEGG pathways (count: 2)

KEGG pathways by PBA (count: 2)

KEGG pathways by database search (count: 0)

Gene related BioCarta pathways (count: 4)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 4)

Gene related interactors from protein-protein interactions data in HPRD (count: 7)

Related other genetic factors
Gene related SNPs (count: 4)

Literature-origin SNPs (count: 1)

LD-proxies (count: 3)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Gene relationship with MDD

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Region: chr1:115285918..115338236 View in gBrowse
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