BDgene

SNP Report

Basic Info
Name rs778294 dbSNP Ensembl
Location chr13:105489886 - 105489886(1)
Variant Alleles C/T
Ancestral Allele C
Minor Allele T
Minor Allele Frequence 0.217053
Functional Annotation 3_prime_UTR_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; synonymous_variant.
Consequence to Transcript 3_prime_UTR_variant(ENST00000471432, ENST00000601240); intron_variant(ENST00000329625, ENST00000375936, ENST00000473269, ENST00000488534, ENST00000489237, ENST00000559369, ENST00000600388, ENST00000618629); NMD_transcript_variant(ENST00000471432, ENST00000473269, ENST00000488534, ENST00000489237, ENST00000559369, ENST00000595812, ENST00000600388, ENST00000601240); non_coding_transcript_exon_variant(ENST00000448407); non_coding_transcript_variant(ENST00000448407); synonymous_variant(ENST00000595812)
No. of Studies 10 (Positive: 3; Negative: 7; Trend: 0)
Source Literature
Overlap with SZ? YES
Overlap with MDD? NO

SNP related studies (count: 10)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Grigoroiu-Serbanescu, M.,2010 C/T Allelic association analysis: for non-psychotic patients, P-...... Allelic association analysis: for non-psychotic patients, P-value = 0.286, OR(95%CI)=0.68(0.34-1.38); for psychotic patients, P-value = 0.3657, OR(95%CI)=1.16(0.83-1.63) More... No significant association was observed in BD. No significant association was observed in BD. Negative
Muller, D. J.,2011 C/T FBAT: for total sample, variance of the S-statistic=56.9, Z-...... FBAT: for total sample, variance of the S-statistic=56.9, Z-score=-1.03, P-value = 0.3; for European sample, variance of the S-statistic=53.6, Z-score=-1, P-value = 0.32; for BD patients with psychotic symptoms, variance of the S-statistic=28.3, Z-score=-0.47, P-value = 0.64; for BD patients without psychotic symptoms, variance of the S-statistic=19, Z-score=-0.69, P-value = 0.49 More... No significant association was observed. No significant association was observed. Negative
Maheshwari, M.,2009 A/G TDT: Raw TDT P-value = 0.134, Adaptive permutation corrected...... TDT: Raw TDT P-value = 0.134, Adaptive permutation corrected P-value = 0.258 STEPC: sib_tdt P-value = 0.017, TG P-value = 0.023 More... No significant allelic association with BP was found, but as...... No significant allelic association with BP was found, but association underlies the previously observed linkage signals in the CNGsample set was found. More... Positive
Hattori, E.,2003 A/G G Association analysis: for CNG pedigrees, TDT P-value = 0.018...... Association analysis: for CNG pedigrees, TDT P-value = 0.018, Transmission Ratio=0.83; for NIMH pedigrees, TDT P-value = 0.24, Transmission Ratio=0.61 More... Significant association was found in BD. Significant association was found in BD. Positive
Schumacher, J.,2004 C/T Association analysis: allele P-value = 0.337, OR=1.13, genot...... Association analysis: allele P-value = 0.337, OR=1.13, genotype P-value = 0.587, OR=1.19 More... No significant association was observed in BD. No significant association was observed in BD. Negative
Shi, J., 2008 (a) T OR (95% CI)=0.83 (0.60-1.16) , Z test P-value = 0.28 for Eu...... OR (95% CI)=0.83 (0.60-1.16) , Z test P-value = 0.28 for European samples. More... No single maker showed evidence of overall association with ...... No single maker showed evidence of overall association with BP. More... Negative
Williams, N. M., 2006 allelic P-value = 0.35, Gene-wide test P-value = 0.045 in Bi...... allelic P-value = 0.35, Gene-wide test P-value = 0.045 in Bipolar I Disorder More... We observed significant evidence for whole-gene association ...... We observed significant evidence for whole-gene association (P=.04). More... Negative
Bass, N. J.,2009 C/T chi-squared tests: for BP, allele, X2(1 d.f.)=0.0...... chi-squared tests: for BP, allele, X2(1 d.f.)=0.033, P-value = 0.856 More... No significant association was observed. No significant association was observed. Negative
Zhang, Z.,2009(a) A/G Allelic association: Odds ratio (95% CI)=0.77(0.59-1.00), P-...... Allelic association: Odds ratio (95% CI)=0.77(0.59-1.00), P-value = 0.047 More... Significant association was observed Significant association was observed Positive
Detera-Wadleigh, S. D., 2006 A/G Fisher P-value = 0.7598 for all, P-value = 0.8368 for BP Onl...... Fisher P-value = 0.7598 for all, P-value = 0.8368 for BP Only More... Negative

SNP related genes (count: 2)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
DAOA-AS1 DAOA antisense RNA 1 13q33.2 Mapped by Literature SNP
DAOA D-amino acid oxidase activator 13q33.2 21(13/7/1)

SNPs in LD with rs778294 (count: 9) View in gBrowse (chr13:105477549..105495223 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 9)


Overlap with SZ from cross-disorder studies (count: 5)
Reference Statistical Result Description Result Category
Schumacher, J.,2004 Association analysis:allele P-value = 0.27, OR=1.15, genotype P-value = 0.504, OR=1.21 No significant association was observed in SZ. Negative
Bass, N. J.,2009 chi-squared tests:for SCZ, allele, X2(1 d.f.)=0.141, P-value = 0.707 No significant association was observed. Negative
Shi, J., 2008 (a) OR (95% CI)=0.94 (0.85-1.04), Z test P-value = 0.21 all samples; OR (95% CI)=0.92 (0.76-1.12), Z test P-value = 0.41 for Asian; OR (95% CI)=0.92 (0.82-1.05), Z test P-value = 0.21 for European. No association was detected with schizophrenia in allelic association studies. Negative
Detera-Wadleigh, S. D., 2006 Fisher P-value = 0.7598 for all, P-value = 0.9373 for SCZ Only Negative
Williams, N. M., 2006 allelic P-value = 0.63 in Schizophrenia We found no evidence for allelic or genotypic association with any of the polymorphisms studied for schizophrenia. We observed nominally significant evidence (P=.01-.047) for allelic association with 3 of the polymorphisms for bipolar disorder and significant evidence for whole-gene association (P=.04). Negative

Overlap with MDD from cross-disorder studies (count: 0)