Study Report

Reference	Pisante, A.,2009 PMID: 19436241
Citation	Pisante, A., M. Bronstein, et al. (2009). "A variant in the reelin gene increases the risk of schizophrenia and schizoaffective disorder but not bipolar disorder." Psychiatr Genet 19(4): 212.
Disease Type	Bipolar Disorder & Schizophrenia
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	172 (85 women and 87 men) for schizoaffective disorder(SA); 247 (122 women and 125 men) for bipolar disorder(BD) cases;1312 healthy individuals for controls
SNP/Region/Marker Size	1 SNP
Predominant Ethnicity
Population	Israeli(Ashkenazi Jewish)
Gender	85 women and 87 men for schizoaffective disorder(SA);122 women and 125 men for bipolar disorder(BD) cases.

Sample Diagnosis	DSM
Sample Status	The case samples were collected in Israel by the patients'physicians in specialized clinics. For controls we haveused the same 1312 healthy individuals analyzed by Shifman et al. (2008). All cases and controls belong to the Ashkenazi Jewish population in Israel. All samples are part of the Hebrew University Genetic Resource,www.hugr.org.
Technique	genotyping
Statistical Method	The P values were calculated using a standard two-tail X2 test.
Result Summary	The GG genotype frequency of rs7341475 in male SA and BD cases was 0.68 and 0.57, respectively; 0.73 and 0.62 for SA and BD females, respectively. The GG genotype frequency in the control samples was 0.62 and 0.61 for men and women, respectively. Similar to SZ, a significant effect was only seen in SA females (P=0.035). No association was found for BD (women or men). Statistical power of the current association is modest, thus an effect for BD cannot be ruled out.