Gene Report

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Basic Info

Approved Symbol	GPX6
Previous Symbol	GPXP3
Approved Name	glutathione peroxidase 6
Previous Name	glutathione peroxidase pseudogene 3, "glutathione peroxidase 6 (olfactory)"
Location	6p22.1
Position	chr6:28503296-28528215, -1
External Links	HGNC: 4558 Entrez Gene: 257202 Ensembl: ENSG00000198704 UCSC: uc021yrx.1
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Saito T., 2014	SNP: rs6927023	The associated SNP in this gene showed significant association with BD.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 4)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0055114	oxidation-reduction process	biological process	IEA	43
GO:0006979	response to oxidative stress	biological process	IEA	11
GO:0004602	glutathione peroxidase activity	molecular function	IEA	4
GO:0005576	extracellular region	cellular component	IEA	97

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in BDgene	Brief Description
hsa00590	Arachidonic acid metabolism	7

ID	Name	No. of Genes in BDgene	Brief Description
hsa00480	Glutathione metabolism	8

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 2)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs6927023	chr6:28486444 - 28486444(1)		1(1/0/0)

rs_ID	Literature-origin SNPs with LD	Location	Functional Annotation
rs442174		chrCHR_HSCHR6_MHC_COX_CTG1:28524330 - 28524330(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 6	chr6:0-170805979	3 (0/3/0)
6p22	chr6:15200000-30500000	1 (0/1/0)
6p23-p21.1	chr6:13400000-46200000	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
24888570	The associated SNP in this gene showed no association with SZ.	Positive

Gene relationship with MDD

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Region: chr6:28503296..28528215 View in gBrowse