SNP Report

Basic Info

Name	rs3924999 dbSNP Ensembl
Location	chr8:32595840 - 32595840(1)
Variant Alleles	G/A
Ancestral Allele	G
Minor Allele	A
Minor Allele Frequence	0.385184
Functional Annotation	missense_variant. Polyphen Annotation: benign(ENST00000287842, ENST00000356819, ENST00000405005, ENST00000518104, ENST00000519301, ENST00000520407, ENST00000521670, ENST00000523079, ENST00000523534, ENST00000631040) SIFT Annotation: tolerated(ENST00000631040); deleterious(ENST00000287842, ENST00000356819, ENST00000405005, ENST00000518104, ENST00000519301, ENST00000520407, ENST00000521670, ENST00000523079, ENST00000523534)
Consequence to Transcript	missense_variant(ENST00000287842, ENST00000356819, ENST00000405005, ENST00000518104, ENST00000519301, ENST00000520407, ENST00000521670, ENST00000523079, ENST00000523534, ENST00000631040)
No. of Studies	2 (Positive: 0; Negative: 2; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	NO

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Moon, E.,2011	A/G		For BD: Recessive model: Yates Chi-Square/P-value = 0.45/0.5...... For BD: Recessive model: Yates Chi-Square/P-value = 0.45/0.50; Dominant model: Fisher exact P-value = 0.05/0.82 More...	No significant association was observed. No significant association was observed.	Negative
Perlis, 2008			Mean X²=3.21, P-value = 0.41 in gene-based associ...... Mean X²=3.21, P-value = 0.41 in gene-based association tests More...		Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
NRG1	neuregulin 1	8p12	15(10/5/0)

SNPs in LD with rs3924999 (count: 0) View in gBrowse (chr8:32595840..32595840 )

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Moon, E.,2011	For SZ:0.45/0.50 model:Pearson Chi-Square/P-value = 0.6/0.43, Yates Chi-Square/P-value = 10.28/0.25, Pearson Chi-Square/P-value = 10.55/0.21;Dominant model:Pearson Chi-Square/P-value = 0.08/0.77, Yates Chi-Square/P-value = 0.13/0.71, Pearson Chi-Square/P-value = 0.2/0.65	No significant association was observed.	Negative

Overlap with MDD from cross-disorder studies (count: 0)