SNP Report

Basic Info

Name	rs3803300 dbSNP Ensembl
Location	chr14:104803442 - 104803442(1)
Variant Alleles	T/C
Ancestral Allele	C
Minor Allele	T
Minor Allele Frequence	0.328874
Functional Annotation	3_prime_UTR_variant; downstream_gene_variant.
Consequence to Transcript	3_prime_UTR_variant(ENST00000342537); downstream_gene_variant(ENST00000555360)
No. of Studies	2 (Positive: 2; Negative: 0; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	NO

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Karege, F.,2012	G/A		Association analysis: chi square=14.5; df=1; P-value = 0.000...... Association analysis: chi square=14.5; df=1; P-value = 0.0001; P-value(adjusted)=0.001; OR(95%CI)=3.14(1.7-5.8) More...	Significant association was observed in BD. Significant association was observed in BD.	Positive
Karege, F.,2010	G/A		single-locus analysis: z=1.52; P-value = 0.126 single-locus analysis: z=1.52; P-value = 0.126	Significant association was found in BD. Significant association was found in BD.	Positive

SNP related genes (count: 2)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
ZBTB42	zinc finger and BTB domain containing 42	14q32.33	Mapped by Literature SNP
AKT1	v-akt murine thymoma viral oncogene homolog 1	14q32.33	3(3/0/0)

SNPs in LD with rs3803300 (count: 0) View in gBrowse (chr14:104803442..104803442 )

Overlap with SZ from cross-disorder studies (count: 2)

Reference	Statistical Result	Description	Result Category
Karege, F.,2012	Association analysis:chi square=4.40;df=1;P-value = 0.04;P-value(adjusted)>0.05;OR(95%CI)=2.11(1.0-4.4).Meta analysis:The p-value based on the z statistic was (z=4.75) P-value < 0.0001.	Significant association was observed in SZ.	Positive
Karege, F.,2010	single-locus analysis:z=1.80;P-value = 0.072	No significant association was observed.	Negative

Overlap with MDD from cross-disorder studies (count: 0)