Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	ACP6
Symbol Alias	LPAP, ACPL1
Approved Name	acid phosphatase 6, lysophosphatidic
Location	1q21
Position	chr1:147629652-147670496, -1
External Links	HGNC: 29609 Entrez Gene: 51205 Ensembl: ENSG00000162836 UCSC: uc001epr.2
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Noor A., 2014		Selected stringent CNV related to this gene is validated by qPCR from BD case data.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 7)

GO terms by PBA (count: 0)

GO terms by database search (count: 7)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0003993	acid phosphatase activity	molecular function	IEA	1
GO:0016311	dephosphorylation	biological process	IDA[10506173]; IEA	14
GO:0052642	lysophosphatidic acid phosphatase activity	molecular function	IDA[10506173]	1
GO:0005737	cytoplasm	cellular component	IDA[12010880]	322
GO:0005739	mitochondrion	cellular component	IDA[10506173]	75
GO:2001311	lysobisphosphatidic acid metabolic process	biological process	IDA[23807634]	1
GO:0006644	phospholipid metabolic process	biological process	IMP[10506173]	18

Gene related KEGG pathways (count: 2)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 2)

ID	Name	No. of Genes in BDgene	Brief Description
hsa00361	gamma-Hexachlorocyclohexane degradation	2
hsa00740	Riboflavin metabolism	2

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
ACP6	C2orf18	NO	yeast 2-hybrid	16169070
ACP6	GNG7	NO	yeast 2-hybrid	16169070

Related other genetic factors

Gene related SNPs (count: 34)

Literature-origin SNPs (count: 2)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs946903	chr1:147625465 - 147625465(1)	3_prime_UTR_variant; downstream_gene_variant	1(0/1/0)
rs3766512	chr1:147625834 - 147625834(1)	3_prime_UTR_variant; downstream_gene_variant	1(0/1/0)

LD-proxies (count: 32)

rs_ID	Location	Functional Annotation
rs1578723	chr1:147661492 - 147661492(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs3820127	chr1:147660625 - 147660625(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs12025871	chr1:147663226 - 147663226(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs11240098	chr1:147662710 - 147662710(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs11240102	chr1:147663733 - 147663733(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs11240100	chr1:147663473 - 147663473(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs3766506	chr1:147665250 - 147665250(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs3766507	chr1:147665106 - 147665106(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs3820126	chr1:147665867 - 147665867(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs12409268	chr1:147633200 - 147633200(1)	intron_variant
rs12132534	chr1:147627185 - 147627185(1)	downstream_gene_variant
rs2153463	chr1:147652507 - 147652507(1)	3_prime_UTR_variant; downstream_gene_variant; intron_variant; missense_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; synonymous_variant; upstream_gene_variant
rs12119079	chr1:147656899 - 147656899(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs17361839	chr1:147627887 - 147627887(1)	downstream_gene_variant
rs12037951	chr1:147631053 - 147631053(1)	downstream_gene_variant; stop_lost
rs6667707	chr1:147627080 - 147627080(1)	downstream_gene_variant
rs2297961	chr1:147630356 - 147630356(1)	3_prime_UTR_variant; downstream_gene_variant
rs867270	chr1:147624993 - 147624993(1)	3_prime_UTR_variant; downstream_gene_variant
rs1417279	chr1:147636093 - 147636093(1)	intron_variant
rs6677434	chr1:147636131 - 147636131(1)	intron_variant
rs6681587	chr1:147631238 - 147631238(1)	intron_variant
rs10157759	chr1:147635323 - 147635323(1)	intron_variant
rs12045709	chr1:147640003 - 147640003(1)	downstream_gene_variant; intron_variant
rs7539714	chr1:147640031 - 147640031(1)	downstream_gene_variant; intron_variant
rs6663082	chr1:147636166 - 147636166(1)	intron_variant
rs870434	chr1:147637584 - 147637584(1)	downstream_gene_variant; intron_variant
rs3766510	chr1:147658107 - 147658107(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs3818888	chr1:147659595 - 147659595(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs2275552	chr1:147659830 - 147659830(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs10793694	chr1:147641835 - 147641835(1)	downstream_gene_variant; intron_variant
rs6674938	chr1:147659350 - 147659350(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs12045199	chr1:147646668 - 147646668(1)	3_prime_UTR_variant; downstream_gene_variant; intron_variant

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Abdul Noor[2014]_1	chr1:144943150-146293282 (NCBI Build 36/hg18)	1	1q21.1	duplication

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
1p13.2-1q21.3	chr1:111200000-155100000	1 (1/0/0)
1p32.1-q31.1	chr1:58500000-190800000	1 (0/1/0)
Chr 1	chr1:0-248956422	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr1:147629652..147670496 View in gBrowse